Infinite Protein Self-Assembly in Health and Disease

Informazioni relative al progetto

Agglomerates

ID dell’accordo di sovvenzione: 819318

DOI

10.3030/819318

Progetto chiuso

Data della firma CE 25 Febbraio 2019

Data di avvio 1 Aprile 2019

Data di completamento 31 Marzo 2026

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 574 819,00

Contributo UE

€ 2 574 819,00

Coordinato da

UNIVERSITE DE GENEVE
Switzerland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (24)

Uncovering the mechanism for polar sequestration of the major bacterial sugar regulator by high-throughput screens and 3D interaction modeling

Autori: Nitsan Albocher-Kedem, Meta Heidenreich, Amir Fadel, Elizabeta Sirotkin, Omer Goldberger, Anat Nussbaum-Shochat, Emmanuel D. Levy, Ora Schueler-Furman, Maya Schuldiner, Orna Amster-Choder
Pubblicato in: Cell Reports, Numero 44, 2026, Pagina/e 115436, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2025.115436

How gene duplication diversifies the landscape of protein oligomeric state and function

Autori: Saurav Mallik, Dan S Tawfik, Emmanuel D Levy
Pubblicato in: Current Opinion in Genetics & Development, Numero 76, 2025, Pagina/e 101966, ISSN 0959-437X
Editore: Elsevier BV
DOI: 10.1016/j.gde.2022.101966

Protein Abundance Biases the Amino Acid Composition of Disordered Regions to Minimize Non-functional Interactions

Autori: Benjamin Dubreuil, Or Matalon, Emmanuel D. Levy
Pubblicato in: Journal of Molecular Biology, Numero 431/24, 2019, Pagina/e 4978-4992, ISSN 0022-2836
Editore: Academic Press
DOI: 10.1016/j.jmb.2019.08.008

Mutational biases favor complexity increases in protein interaction networks after gene duplication

Autori: Angel F Cisneros, Lou Nielly-Thibault, Saurav Mallik, Emmanuel D Levy, Christian R Landry
Pubblicato in: Molecular Systems Biology, Numero 20, 2026, Pagina/e 549-572, ISSN 1744-4292
Editore: Nature Publishing Group
DOI: 10.1038/s44320-024-00030-z

Mutant libraries reveal negative design shielding proteins from supramolecular self-assembly and relocalization in cells

Autori: Hector Garcia Seisdedos, Tal Levin, Gal Shapira, Saskia Freud, Emmanuel D. Levy
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 119, 2022, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2101117119

Proteomic analysis reveals the direct recruitment of intrinsically disordered regions to stress granules in S. cerevisiae.

Autori: Mang Zhu; Erich R. Kuechler; Joyce Zhang; Or Matalon; Benjamin Dubreuil; Analise Hofmann; Christopher J. R. Loewen; Emmanuel D. Levy; Joerg Gsponer; Thibault Mayor
Pubblicato in: Journal of Cell Science, Numero 1, 2020, ISSN 0021-9533
Editore: The Company of Biologists Ltd.
DOI: 10.1242/jcs.244657

Mapping interactions between disordered regions reveals promiscuity in biomolecular condensate formation

Autori: Atar Gilat, Alexander I. Alexandrov, Benjamin Dubreuil, Emmanuel D. Levy
Pubblicato in: Nature Communications, Numero 17, 2026, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-026-73800-y

Rapid and sensitive protein complex alignment with Foldseek-Multimer

Autori: Woosub Kim, Milot Mirdita, Eli Levy Karin, Cameron L. M. Gilchrist, Hugo Schweke, Johannes Söding, Emmanuel D. Levy, Martin Steinegger
Pubblicato in: Nature Methods, Numero 22, 2025, Pagina/e 469-472, ISSN 1548-7091
Editore: Nature Publishing Group
DOI: 10.1038/s41592-025-02593-7

Designer protein assemblies with tunable phase diagrams in living cells

Autori: Meta Heidenreich, Joseph M. Georgeson, Emanuele Locatelli, Lorenzo Rovigatti, Saroj Kumar Nandi, Avital Steinberg, Yotam Nadav, Eyal Shimoni, Samuel A. Safran, Jonathan P. K. Doye, Emmanuel D. Levy
Pubblicato in: Nature Chemical Biology, 2020, ISSN 1552-4450
Editore: Nature Publishing Group
DOI: 10.1038/s41589-020-0576-z

An atlas of protein homo-oligomerization across domains of life

Autori: Hugo Schweke, Tal Levin, Martin Pacesa, Casper A. Goverde, Prasun Kumar, Yoan Duhoo, Lars J. Dornfeld, Benjamin Dubreuil, Sandrine Georgeon, Sergey Ovchinnikov, Derek N. Woolfson, Bruno E. Correia, Su
Pubblicato in: Cell, 2024, ISSN 1097-4172
Editore: elsevier
DOI: 10.1101/2023.06.09.544317

QSalignWeb: A Server to Predict and Analyze Protein Quaternary Structure

Autori: Sucharita Dey, Jaime Prilusky, Emmanuel D. Levy
Pubblicato in: Frontiers in Molecular Biosciences, Numero 8, 2022, ISSN 2296-889X
Editore: Frontiers Media SA
DOI: 10.3389/fmolb.2021.787510

<scp>CC⁺</scp>: A searchable database of validated coiled coils in <scp>PDB</scp> structures and <scp>AlphaFold2</scp> models

Autori: Prasun Kumar; Rokas Petrenas; William M. Dawson; Hugo Schweke; Emmanuel D. Levy; Derek N. Woolfson
Pubblicato in: Crossref, Numero 5, 2023, ISSN 0961-8368
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1002/pro.4789

Discriminating physiological from non‐physiological interfaces in structures of protein complexes: A community‐wide study

Autori: Hugo Schweke; Qifang Xu; Gerardo Tauriello; Lorenzo Pantolini; Torsten Schwede; Frédéric Cazals; Alix Lhéritier; Juan Fernandez‐Recio; Luis Angel Rodríguez‐Lumbreras; Ora Schueler‐Furman; Julia K. Varga; Brian Jiménez‐García; Manon F. Réau; Alexandre M. J. J. Bonvin; Castrense Savojardo; Pier‐Luigi Martelli; Rita Casadio; Jérôme Tubiana; Haim J. Wolfson; Romina Oliva; Didier Bar
Pubblicato in: Crossref, Numero 5, 2023, ISSN 1615-9853
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/pmic.202200323

Principles of cotranslational mitochondrial protein import

Autori: Zikun Zhu, Saurav Mallik, Taylor A. Stevens, Riming Huang, Emmanuel D. Levy, Shu-ou Shan
Pubblicato in: Cell, Numero 188, 2026, Pagina/e 5605-5617.e14, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2025.07.021

Molecular and environmental determinants of biomolecular condensate formation

Autori: José A. Villegas, Meta Heidenreich, Emmanuel D. Levy
Pubblicato in: Nature Chem. Bio., 2022, ISSN 1552-4450
Editore: Nature Publishing Group
DOI: 10.1038/s41589-022-01175-4

PDB-wide identification of physiological hetero-oligomeric assemblies based on conserved quaternary structure geometry

Autori: Sucharita Dey, Emmanuel D. Levy
Pubblicato in: Structure, Numero 29/11, 2021, Pagina/e 1303-1311.e3, ISSN 0969-2126
Editore: Cell Press
DOI: 10.1016/j.str.2021.07.012

<scp>CC⁺</scp>: A searchable database of validated coiled coils in <scp>PDB</scp> structures and <scp>AlphaFold2</scp> models

Autori: Prasun Kumar; Rokas Petrenas; William M. Dawson; Hugo Schweke; Emmanuel D. Levy; Derek N. Woolfson
Pubblicato in: Protein Science, Numero 12, 2023, ISSN 0961-8368
Editore: Cold Spring Harbor Laboratory Press

Affinity and Valence Impact the Extent and Symmetry of Phase Separation of Multivalent Proteins

Autori: Saroj Kumar Nandi; Daniel Österle; Meta Heidenreich; Emmanuel D. Levy; Samuel A. Safran
Pubblicato in: Crossref, Numero 2, 2022, ISSN 0031-9007
Editore: American Physical Society
DOI: 10.1103/physrevlett.129.128102

Structural determinants of co-translational protein complex assembly

Autori: Saurav Mallik, Johannes Venezian, Arseniy Lobov, Meta Heidenreich, Hector Garcia-Seisdedos, Todd O. Yeates, Ayala Shiber, Emmanuel D. Levy
Pubblicato in: Cell, 2026, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1101/2024.01.20.576408

PDBe-KB: collaboratively defining the biological context of structural data

Autori: Mihaly Varadi; Stephen Anyango; David R. Armstrong; John M. Berrisford; Preeti Choudhary; Mandar Deshpande; Nurul Nadzirin; Sreenath Nair; Lukáš Pravda; Ahsan Tanweer; Bissan Al-Lazikani; Claudia Andreini; Geoffrey J. Barton; David Bednar; Karel Berka; Tom L. Blundell; Kelly P Brock; José María Carazo; Jiri Damborsky; Alessia David; Sucharita Dey; Roland L. Dunbrack; Juan Fernandez Recio; Fran
Pubblicato in: D534-D542, Numero 2, 2021, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkab988

A unified statistical potential reveals that amino acid stickiness governs nonspecific recruitment of client proteins into condensates

Autori: José A. Villegas; Emmanuel D. Levy
Pubblicato in: Crossref, Numero 1, 2022, ISSN 0961-8368
Editore: Cold Spring Harbor Laboratory Press
DOI: 10.1002/pro.4361

Abundance Imparts Evolutionary Constraints of Similar Magnitude on the Buried, Surface, and Disordered Regions of Proteins

Autori: Benjamin Dubreuil, Emmanuel D. Levy
Pubblicato in: Frontiers in Molecular Biosciences, Numero 8, 2021, ISSN 2296-889X
Editore: Frontiers
DOI: 10.3389/fmolb.2021.626729

A pharmacological modality to sequester homomeric proteins

Autori: Ella Livnah, Ohad Suss, Adi Rogel, Atar Gilat, Yuval Abdan, Jose D Villegas, Barr Tivon, Shira Albeck, Tamar Unger, Ofra Golani, Inna Goliand, David Margulies, Emmanuel D Levy, Nir London
Pubblicato in: Nature chemical biology, 2026, ISSN 1552-4450
Editore: Nature Publishing Group
DOI: 10.1101/2025.03.05.641597

Mutation-induced filaments of folded proteins are inert and non-toxic in a cellular system

Autori: Tal Levin, Hector Garcia-Seisdedos, Arseniy Lobov, Matthias Wojtynek, Alexander Alexandrov, Ghil Jona, Dikla Levi, Ohad Medalia, Emmanuel D Levy
Pubblicato in: Molecular Systems Biology, Numero 21, 2026, Pagina/e 1306-1324, ISSN 1744-4292
Editore: Nature Publishing Group
DOI: 10.1038/s44320-025-00144-y

Other (1)

The phase separation landscape of genome-wide genetic perturbations

Autori: Meta Heidenreich, Saurabh Mathur, Tong Shu, Ying Xie, David Sriker, Benjamin Dubreuil, Liam Holt, Emmanuel D. Levy
Pubblicato in: 2026
Editore: openRxiv
DOI: 10.1101/2024.10.25.620319