Understanding Circumventing Antibiotic REsistance

Project Information

uCARE

Grant agreement ID: 819454

DOI

10.3030/819454

Project closed

EC signature date 14 February 2019

Start date 1 March 2019

End date 31 August 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 986 004,00

EU contribution

€ 1 986 004,00

Coordinated by

EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (10)

SARS-CoV-2 infection remodels the host protein thermal stability landscape.

Author(s): Joel Selkrig; Megan L. Stanifer; André Mateus; Karin Mitosch; Inigo Barrio-Hernandez; Mandy Rettel; Heeyoung Kim; Carlos G P Voogdt; Philipp Walch; Philipp Walch; Carmon Kee; Nils Kurzawa; Nils Kurzawa; Frank Stein; Clement M. Potel; Anna Jarzab; Bernhard Kuster; Ralf Bartenschlager; Ralf Bartenschlager; Steeve Boulant; Steeve Boulant; Pedro Beltrao; Athanasios Typas; Mikhail M. Savitski
Published in: Molecular Systems Biology, Vol 17, Iss 2, Pp n/a-n/a (2021), Issue 1, 2021, ISSN 1744-4292
Publisher: Nature Publishing Group
DOI: 10.21203/rs.3.rs-105193/v1

Harnessing gut microbial communities to unravel microbiome functions

Author(s): Samir Giri, Handuo Shi, Athanasios Typas, Kerwyn Casey Huang
Published in: Current Opinion in Microbiology, Issue 83, 2025, Page(s) 102578, ISSN 1369-5274
Publisher: Elsevier BV
DOI: 10.1016/j.mib.2024.102578

Randomly barcoded transposon mutant libraries for gut commensals II: Applying libraries for functional genetics

Author(s): Carlos Geert Pieter Voogdt, Surya Tripathi, Stefan Oliver Bassler, Saria A. McKeithen-Mead, Emma R. Guiberson, Alexandra Koumoutsi, Afonso Martins Bravo, Cullen Buie, Michael Zimmermann, Justin L. Sonnenburg, Athanasios Typas, Adam M. Deutschbauer, Anthony L. Shiver, Kerwyn Casey Huang
Published in: Cell Reports, Issue 43, 2024, Page(s) 113519, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2023.113519

Unravelling the collateral damage of antibiotics on gut bacteria

Author(s): Lisa Maier, Camille V. Goemans, Jakob Wirbel, Michael Kuhn, Claudia Eberl, Mihaela Pruteanu, Patrick Müller, Sarela Garcia-Santamarina, Elisabetta Cacace, Boyao Zhang, Cordula Gekeler, Tisya Banerjee, Exene Erin Anderson, Alessio Milanese, Ulrike Löber, Sofia K. Forslund, Kiran Raosaheb Patil, Michael Zimmermann, Bärbel Stecher, Georg Zeller, Peer Bork, Athanasios Typas
Published in: Nature, Issue 599/7883, 2021, Page(s) 120-124, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-021-03986-2

Bioactivity assessment of natural compounds using machine learning models trained on target similarity between drugs

Author(s): Vinita Periwal, Stefan Bassler, Sergej Andrejev, Natalia Gabrielli, Kaustubh Raosaheb Patil, Athanasios Typas, Kiran Raosaheb Pati
Published in: PLOS Computational Biology, 2023, ISSN 1553-7358
Publisher: Public Library of Science
DOI: 10.1371/journal.pcbi.1010029

Randomly barcoded transposon mutant libraries for gut commensals I: Strategies for efficient library construction

Author(s): Surya Tripathi, Carlos Geert Pieter Voogdt, Stefan Oliver Bassler, Mary Anderson, Po-Hsun Huang, Nazgul Sakenova, Tümay Capraz, Sunit Jain, Alexandra Koumoutsi, Afonso Martins Bravo, Valentine Trotter, Michael Zimmerman, Justin L. Sonnenburg, Cullen Buie, Athanasios Typas, Adam M. Deutschbauer, Anthony L. Shiver, Kerwyn Casey Huang
Published in: Cell Reports, Issue 43, 2024, Page(s) 113517, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2023.113517

High-throughput anaerobic screening for identifying compounds acting against gut bacteria in monocultures or communities

Author(s): Patrick Müller, Jacobo de la Cuesta-Zuluaga, Michael Kuhn, Maral Baghai Arassi, Tim Treis, Sonja Blasche, Michael Zimmermann, Peer Bork, Kiran Raosaheb Patil, Athanasios Typas, Sarela Garcia-Santamarina, Lisa Maier
Published in: Nature Protocols, Issue 19, 2024, Page(s) 668-699, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-023-00926-4

Emergence of community behaviors in the gut microbiota upon drug treatment

Author(s): Sarela Garcia-Santamarina, Michael Kuhn, Saravanan Devendran, Lisa Maier, Marja Driessen, André Mateus, Eleonora Mastrorilli, Ana Rita Brochado, Mikhail M. Savitski, Kiran R. Patil, Michael Zimmermann, Peer Bork, Athanasios Typas
Published in: Cell, Issue 187, 2024, Page(s) 6346-6357.e20, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2024.08.037

Systematic mapping of antibiotic cross-resistance and collateral sensitivity with chemical genetics

Author(s): Nazgul Sakenova, Elisabetta Cacace, Askarbek Orakov, Florian Huber, Vallo Varik, George Kritikos, Jan Michiels, Peer Bork, Pascale Cossart, Camille V. Goemans, Athanasios Typas
Published in: Nature Microbiology, Issue 10, 2025, Page(s) 202-216, ISSN 2058-5276
Publisher: Springer Nature Limited
DOI: 10.1038/s41564-024-01857-w

Towards a mechanistic understanding of reciprocal drug–microbiome interactions

Author(s): Michael Zimmermann, Kiran Raosaheb Patil, Athanasios Typas, Lisa Maier
Published in: Molecular Systems Biology, Issue 17/3, 2021, ISSN 1744-4292
Publisher: Nature Publishing Group
DOI: 10.15252/msb.202010116

Other (1)

Emergence of community behaviors in the gut microbiota upon drug treatment

Author(s): Sarela Garcia-Santamarina, Michael Kuhn, Saravanan Devendran, Lisa Maier, Marja Driessen, André Mateus, Eleonora Mastrorilli, Ana Rita Brochado, Mikhail M. Savitski, Kiran R. Patil, Michael Zimmermann, Peer Bork, Athanasios Typas
Published in: bioRxiv, 2023
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.06.13.544832

Intellectual Property Rights

Patent (1)

COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND/OR TREATMENT OF DYSBIOSIS AND ANTIBACTERIAL ANTIDOTES FOR MICROBIOME-PROTECTION

Application/Publication number: 19 216548
Date: 2019-12-16
Applicant(s): EUROPEAN MOLECULAR BIOLOGY LABORATORY