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Chromosome Replication Visualised by Cryo-EM

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Publications

Caught in the act: structural dynamics of replication origin activation and fork progression

Author(s): Jacob S. Lewis, Alessandro Costa
Published in: Biochemical Society Transactions, Issue 48/3, 2020, Page(s) 1057-1066, ISSN 0300-5127
DOI: 10.1042/bst20190998

Microtubule Nucleation Properties of Single Human γTuRCs Explained by Their Cryo-EM Structure

Author(s): Tanja Consolati; Julia Locke; Johanna Roostalu; Zhuo Angel Chen; Julian Gannon; Jayant Asthana; Wei Ming Lim; Fabrizio Martino; Milos A. Cvetkovic; Juri Rappsilber; Alessandro Costa; Thomas Surrey
Published in: Developmental Cell, 2020, ISSN 1534-5807
DOI: 10.1016/j.devcel.2020.04.019

A Structure-Based Mechanism for DNA Entry into the Cohesin Ring

Author(s): Torahiko L. Higashi, Patrik Eickhoff, Joana S. Sousa, Julia Locke, Andrea Nans, Helen R. Flynn, Ambrosius P. Snijders, George Papageorgiou, Nicola O’Reilly, Zhuo A. Chen, Francis J. O’Reilly, Juri Rappsilber, Alessandro Costa, Frank Uhlmann
Published in: Molecular Cell, Issue 79/6, 2020, Page(s) 917-933.e9, ISSN 1097-2765
DOI: 10.1016/j.molcel.2020.07.013

Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer

Author(s): Valerie E Pye; David Rueda; Peter Cherepanov; Marcus Wilson; Mohamed Ghoneim; Ludovic Renault
Published in: Wilson , M , Renault , L , Maskell , D P , Ghoneim , M , Pye , V E , Nans , A , Rueda , D S , Cherepanov , P & Costa , A 2019 , ' Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer ' , Nature Communications , vol. 10 , 4189 . https://doi.org/10.1038/s41467-019-12007-w, 2019, ISSN 2041-1723
DOI: 10.1101/663336

Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM

Author(s): Thomas C. R. Miller, Julia Locke, Julia F. Greiwe, John F. X. Diffley, Alessandro Costa
Published in: Nature, Issue 575/7784, 2019, Page(s) 704-710, ISSN 0028-0836
DOI: 10.1038/s41586-019-1768-0

Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome

Author(s): Patrik Eickhoff, Hazal B. Kose, Fabrizio Martino, Tatjana Petojevic, Ferdos Abid Ali, Julia Locke, Nele Tamberg, Andrea Nans, James M. Berger, Michael R. Botchan, Hasan Yardimci, Alessandro Costa
Published in: Cell Reports, Issue 28/10, 2019, Page(s) 2673-2688.e8, ISSN 2211-1247
DOI: 10.1016/j.celrep.2019.07.104