Chromosome Replication Visualised by Cryo-EM

Pubblicazioni

Caught in the act: structural dynamics of replication origin activation and fork progression

Autori: Jacob S. Lewis, Alessandro Costa
Pubblicato in: Biochemical Society Transactions, Numero 48/3, 2020, Pagina/e 1057-1066, ISSN 0300-5127
Editore: Portland Press, Ltd.
DOI: 10.1042/bst20190998

Microtubule Nucleation Properties of Single Human γTuRCs Explained by Their Cryo-EM Structure

Autori: Tanja Consolati; Julia Locke; Johanna Roostalu; Zhuo Angel Chen; Julian Gannon; Jayant Asthana; Wei Ming Lim; Fabrizio Martino; Milos A. Cvetkovic; Juri Rappsilber; Alessandro Costa; Thomas Surrey
Pubblicato in: Developmental Cell, 2020, ISSN 1534-5807
Editore: Cell Press
DOI: 10.1016/j.devcel.2020.04.019

Mechanism of replication origin melting nucleated by CMG helicase assembly

Autori: Jacob S. Lewis, Marta H. Gross, Joana Sousa, Sarah S. Henrikus, Julia F. Greiwe, Andrea Nans, John F. X. Diffley & Alessandro Costa
Pubblicato in: Nature, 2022, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-022-04829-4

A Structure-Based Mechanism for DNA Entry into the Cohesin Ring

Autori: Torahiko L. Higashi, Patrik Eickhoff, Joana S. Sousa, Julia Locke, Andrea Nans, Helen R. Flynn, Ambrosius P. Snijders, George Papageorgiou, Nicola O’Reilly, Zhuo A. Chen, Francis J. O’Reilly, Juri Rappsilber, Alessandro Costa, Frank Uhlmann
Pubblicato in: Molecular Cell, Numero 79/6, 2020, Pagina/e 917-933.e9, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2020.07.013

Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer

Autori: Valerie E Pye; David Rueda; Peter Cherepanov; Marcus Wilson; Mohamed Ghoneim; Ludovic Renault
Pubblicato in: Nature Communications, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1101/663336

Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM

Autori: Thomas C. R. Miller, Julia Locke, Julia F. Greiwe, John F. X. Diffley, Alessandro Costa
Pubblicato in: Nature, Numero 575/7784, 2019, Pagina/e 704-710, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-019-1768-0

Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome

Autori: Patrik Eickhoff, Hazal B. Kose, Fabrizio Martino, Tatjana Petojevic, Ferdos Abid Ali, Julia Locke, Nele Tamberg, Andrea Nans, James M. Berger, Michael R. Botchan, Hasan Yardimci, Alessandro Costa
Pubblicato in: Cell Reports, Numero 28/10, 2019, Pagina/e 2673-2688.e8, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2019.07.104

Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase

Autori: Julia F. Greiwe, Thomas C. R. Miller, Julia Locke, Fabrizio Martino, Steven Howell, Anne Schreiber, Andrea Nans, John F. X. Diffley & Alessandro Costa
Pubblicato in: Nature Structural & Molecular Biology, 2022, ISSN 1545-9993
Editore: Nature Publishing Group
DOI: 10.1038/s41594-021-00698-z

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