Chromosome Replication Visualised by Cryo-EM

Información del proyecto

CRYOREP

Identificador del acuerdo de subvención: 820102

DOI 10.3030/820102

Fecha de la firma de la CE 17 Diciembre 2018

Fecha de inicio 1 Marzo 2019

Fecha de finalización 31 Agosto 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total € 2 000 000,00

Aportación de la UE € 2 000 000,00

Coordinado por

THE FRANCIS CRICK INSTITUTE LIMITED
United Kingdom

Publicaciones

Peer reviewed articles (8)

Caught in the act: structural dynamics of replication origin activation and fork progression

Autores: Jacob S. Lewis, Alessandro Costa
Publicado en: Biochemical Society Transactions, Edición 48/3, 2020, Página(s) 1057-1066, ISSN 0300-5127
Editor: Portland Press, Ltd.
DOI: 10.1042/bst20190998

Microtubule Nucleation Properties of Single Human γTuRCs Explained by Their Cryo-EM Structure

Autores: Tanja Consolati; Julia Locke; Johanna Roostalu; Zhuo Angel Chen; Julian Gannon; Jayant Asthana; Wei Ming Lim; Fabrizio Martino; Milos A. Cvetkovic; Juri Rappsilber; Alessandro Costa; Thomas Surrey
Publicado en: Developmental Cell, 2020, ISSN 1534-5807
Editor: Cell Press
DOI: 10.1016/j.devcel.2020.04.019

Mechanism of replication origin melting nucleated by CMG helicase assembly

Autores: Jacob S. Lewis, Marta H. Gross, Joana Sousa, Sarah S. Henrikus, Julia F. Greiwe, Andrea Nans, John F. X. Diffley & Alessandro Costa
Publicado en: Nature, 2022, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-022-04829-4

A Structure-Based Mechanism for DNA Entry into the Cohesin Ring

Autores: Torahiko L. Higashi, Patrik Eickhoff, Joana S. Sousa, Julia Locke, Andrea Nans, Helen R. Flynn, Ambrosius P. Snijders, George Papageorgiou, Nicola O’Reilly, Zhuo A. Chen, Francis J. O’Reilly, Juri Rappsilber, Alessandro Costa, Frank Uhlmann
Publicado en: Molecular Cell, Edición 79/6, 2020, Página(s) 917-933.e9, ISSN 1097-2765
Editor: Cell Press
DOI: 10.1016/j.molcel.2020.07.013

Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer

Autores: Valerie E Pye; David Rueda; Peter Cherepanov; Marcus Wilson; Mohamed Ghoneim; Ludovic Renault
Publicado en: Wilson , M , Renault , L , Maskell , D P , Ghoneim , M , Pye , V E , Nans , A , Rueda , D S , Cherepanov , P & Costa , A 2019 , ' Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer ' , Nature Communications , vol. 10 , 4189 . https://doi.org/10.1038/s41467-019-12007-w, 2019, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1101/663336

Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM

Autores: Thomas C. R. Miller, Julia Locke, Julia F. Greiwe, John F. X. Diffley, Alessandro Costa
Publicado en: Nature, Edición 575/7784, 2019, Página(s) 704-710, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-019-1768-0

Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome

Autores: Patrik Eickhoff, Hazal B. Kose, Fabrizio Martino, Tatjana Petojevic, Ferdos Abid Ali, Julia Locke, Nele Tamberg, Andrea Nans, James M. Berger, Michael R. Botchan, Hasan Yardimci, Alessandro Costa
Publicado en: Cell Reports, Edición 28/10, 2019, Página(s) 2673-2688.e8, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2019.07.104

Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase

Autores: Julia F. Greiwe, Thomas C. R. Miller, Julia Locke, Fabrizio Martino, Steven Howell, Anne Schreiber, Andrea Nans, John F. X. Diffley & Alessandro Costa
Publicado en: Nature Structural & Molecular Biology, 2022, ISSN 1545-9993
Editor: Nature Publishing Group
DOI: 10.1038/s41594-021-00698-z