Project description
RNA technologies in cancer detection
Effective management of cancer requires early diagnosis, prognosis classification and efficient monitoring of disease progression after treatment. These necessitate cancer-specific biomarkers that can be screened non-invasively and in a continuous manner. The EU-funded RNADIAGON project focuses on small non-coding RNA (ncRNA) molecules as alternative cancer biomarkers. The main advantage of these RNA molecules is that they circulate freely in body fluids such as blood plasma or are packed in microvesicles secreted from cells, rendering them ideal for non-invasive screening. The identification of cancer-specific ncRNA technologies is expected to assist prompt and accurate cancer detection and improve patient compliance, which is an issue with invading procedures.
Objective
Cancer occurs in more than 2 million individuals every year in Europe alone. It is widely recognized that early diagnosis and monitoring of the disease - during therapy and post-treatment follow-up- is a key step for successful patient management: it helps to offer on-time curative intervention and selecting the most appropriate therapy, improves the quality of life, while contributing to reduce the economic and social burden for both patients and society. There are screening programs available for early detection of some cancers such as colorectal cancer (CRC). Unfortunately, current CRC screening tests suffer with unsatisfactory sensitivity and specificity and low compliance of targeted population. On the other hand, there are cancers with poorly performing biomarkers as in the case of hepatocellular carcinoma (HCC), or no biomarkers at all (e.g. renal cell carcinoma (RCC), which limits not only the screening options but also the diagnosis or monitoring of the disease. Therefore, there is a need for new diagnostic biomarkers and accurate technologies to enable precise detection of asymptomatic tumors in a short time, low costs and, if possible, with minimal invasiveness and risks for the patients. From this perspective, cancer specific small non-coding RNAs (small ncRNAs) circulating in body fluids such as blood serum or plasma present promising diagnostic approach. Project RNADIAGON aims at development of personal skills and knowledge of early-stage and experienced researchers working in the field of small non-coding RNA diagnostics from five European research institutions through their long-term stays at one of the world-leading ncRNAs research centers in United States and traineeships at the education center and manufacturing facilities of industrial partner developing small ncRNAs-based certified diagnostics. This research and innovation staff exchange will increase the scientific excellence and quality of related research in the EU research institutions.
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Coordinator
601 77 Brno
Czechia