Projektbeschreibung
RNA-Technologien für die Krebserkennung
Ein effektives Management von Krebserkrankungen setzt eine frühzeitige Diagnose, die Klassifikation der Prognose und die effiziente Überwachung der Krankheitsprogression nach der Behandlung voraus. Dafür sind krebsspezifische Biomarker erforderlich, die nichtinvasiv und fortlaufend untersucht werden können. Das EU-finanzierte Projekt RNADIAGON konzentriert sich auf kleine Moleküle der nicht kodierenden RNA (ncRNA) als alternative Krebsbiomarker. Der Hauptvorteil dieser RNA-Moleküle liegt darin, dass sie in Körperflüssigkeiten wie Blutplasma frei zirkulieren oder dicht in Mikrovesikel gepackt sind, die von Zellen abgeschieden werden. Damit sind sie perfekt für nichtinvasive Untersuchungen geeignet. Die Bestimmung krebsspezifischer ncRNA-Technologien wird voraussichtlich zu einer raschen und genauen Krebserkennung beitragen und die Therapietreue verbessern, die bei invasiven Verfahren problematisch ist.
Ziel
Cancer occurs in more than 2 million individuals every year in Europe alone. It is widely recognized that early diagnosis and monitoring of the disease - during therapy and post-treatment follow-up- is a key step for successful patient management: it helps to offer on-time curative intervention and selecting the most appropriate therapy, improves the quality of life, while contributing to reduce the economic and social burden for both patients and society. There are screening programs available for early detection of some cancers such as colorectal cancer (CRC). Unfortunately, current CRC screening tests suffer with unsatisfactory sensitivity and specificity and low compliance of targeted population. On the other hand, there are cancers with poorly performing biomarkers as in the case of hepatocellular carcinoma (HCC), or no biomarkers at all (e.g. renal cell carcinoma (RCC), which limits not only the screening options but also the diagnosis or monitoring of the disease. Therefore, there is a need for new diagnostic biomarkers and accurate technologies to enable precise detection of asymptomatic tumors in a short time, low costs and, if possible, with minimal invasiveness and risks for the patients. From this perspective, cancer specific small non-coding RNAs (small ncRNAs) circulating in body fluids such as blood serum or plasma present promising diagnostic approach. Project RNADIAGON aims at development of personal skills and knowledge of early-stage and experienced researchers working in the field of small non-coding RNA diagnostics from five European research institutions through their long-term stays at one of the world-leading ncRNAs research centers in United States and traineeships at the education center and manufacturing facilities of industrial partner developing small ncRNAs-based certified diagnostics. This research and innovation staff exchange will increase the scientific excellence and quality of related research in the EU research institutions.
Wissenschaftliches Gebiet
Schlüsselbegriffe
Programm/Programme
Aufforderung zur Vorschlagseinreichung
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601 77 Brno
Tschechien