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Connecting neural networks: Nervous-system-on-Chip Technology

Descrizione del progetto

DEENESFRITPL

Sviluppo di un nuovo modello organ-on-chip per il sistema nervoso

I modelli in vitro innovativi, i cosiddetti sistemi organ-on-chip, riproducono struttura e funzioni degli organi umani e sono importanti per la ricerca scientifica di base e lo sviluppo preclinico di nuove terapie. La connettività cellulare e l’interconnessione tra diverse componenti dei sistemi di organi sono essenziali per comprendere patologie complesse come quelle neurodegenerative. Il progetto CONNECT, finanziato dall’UE, sta sviluppando modelli in vitro di livello superiore per il sistema nervoso. Il progetto rappresenta un lavoro interdisciplinare che prevede l’impiego di nanofabbricazione, microfluidica, tecnologia delle cellule staminali, ingegneria tissutale e imaging avanzato. Come prova di principio, CONNECT intende dimostrare l’efficacia di questo sistema modello nel trattamento del morbo di Parkinson, aprendo la strada allo sviluppo di nuove strategie terapeutiche.

Obiettivo

Novel micro-engineered in vitro models have been developed to mimic key functions of human organs. These so-called organ-on-chips (OoC) recapitulate the structure and function of human organs, and are particularly important for scientific research that is underlying our knowledge base of diseases and for the pre-clinical development of novel therapeutics. However, the application of these models has its limitations as they do not mimic the complexity and functioning of complete organ systems. Connectivity between cells and the linkage between different components of organ systems is essential in studying complex conditions such as neurodegenerative diseases. These diseases form a major challenge for the scientific community and are associated with a heavy burden on society and the global healthcare systems. To effectively grasp the complexity of neurodegenerative disorders, the CONNECT consortium develops the next level in vitro model systems for the nervous system and puts it firmly on the map. The project acts at the convergence of a multitude of disciplines including nanofabrication, microfluidics, stem cell technology, tissue engineering and advanced imaging. The successful completion of this high risk-high gain project will enable for the first time to study a complete organ system and deliver a viable paradigm for future technology to study connectivity in the nervous system. The proposed work in this project offers a unique opportunity to culture individual nervous system components and connect them in a single “smart” microfluidic chip (CONNECT platform), forming an elementary three compartment model from the central nervous system (CNS) to the peripheral nervous system (PNS). As Proof-of-Principle, CONNECT will demonstrate the feasibility of this system model in Parkinson’s Disease. This provides CONNECT with novel insights, thereby paving the way for future development of therapeutic strategies.

Campo scientifico

Parole chiave

Programma(i)

Argomento(i)

Invito a presentare proposte

H2020-FETPROACT-2018-2020

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Bando secondario

H2020-FETPROACT-2018-01

Meccanismo di finanziamento

RIA - Research and Innovation action

Coordinatore

TECHNISCHE UNIVERSITEIT EINDHOVEN
Contribution nette de l'UE
€ 1 675 000,00
Indirizzo
GROENE LOPER 3
5612 AE Eindhoven
Paesi Bassi

Mostra sulla mappa
Regione
Zuid-Nederland Noord-Brabant Zuidoost-Noord-Brabant
Tipo di attività
Higher or Secondary Education Establishments
Collegamenti
Costo totale
€ 1 675 000,00

Partecipanti (6)

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Ultimo aggiornamento: 2 Aprile 2024

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Permalink: https://cordis.europa.eu/project/id/824070/it

European Union, 2024