A multistage model of thyroid gland function for screening endocrine-disrupting chemicals in a biologically sex-specific manner

Project Information

SCREENED

Grant agreement ID: 825745

DOI 10.3030/825745

Project closed

EC signature date 26 November 2018

Start date 1 January 2019

End date 30 June 2024

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost € 5 655 088,75

EU contribution € 5 655 088,75

Coordinated by

UNIVERSITEIT MAASTRICHT
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (3)

Transcriptomic datasets of effect of EDs on thyroid cells

This deliverable consists of a report describing the transcriptomic data obtained in the 3D in vitro models.

3-5 AOPs for ED-mediated disruption of thyroid function completed in AOP Wiki

This deliverable consists of the submission on the OECD Environmental Health and Safety AOP Wiki of up to 3 AOPs describing the effects of ED’s on thyroid function in mammals in vivo.

Proteomic and datasets of effect of EDs on thyroid cells

This deliverable consists of a report describing the proteomics data obtained in the 3D in vitro models.

Websites, patent fillings, videos etc. (2)

Individualised press release for every partner

Edition of one press release to communicate about the project objectives, approach and results. The press release will be translated into the language of each partner country.

Launch of public website & Twitter account

SCREENED website with project information, news and results allowing interactions with third parties.

Publications

Thesis and dissertations (3)

Liquid chromatography – mass spectrometry, biomaterials and 3D printing in analytical applications

Author(s): Giulia Remaggi
Published in: PhD Thesis, 2023
Publisher: University of Parma, Italy

"A bioinformatic evaluation of endocrine disruptor – dependent proteomic profile of rat thyroid cells tested with an EU Joint Research Centre-submitted in vitro assay: Horizon Project SCREENED #825745"

Author(s): Francesca Pia Quartulli
Published in: 2024, Page(s) 1-96
Publisher: University of Parma, Parma, Italy URL https://www.unipr.it/

"An innovative European Joint Research Center-submitted in vitro assay for screening Endocrine Disruptors effects on thyroid cell function: Horizon Project SCREENED #825745"

Author(s): Elena Caddeo
Published in: PhD Thesis, 2023
Publisher: University of Parma, Italy

Peer reviewed articles (14)

Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism

Author(s): Mírian Romitti, Adrien Tourneur, Barbara de Faria da Fonseca, Gilles Doumont, Pierre Gillotay, Xiao-Hui Liao, Sema Elif Eski, Gaetan Van Simaeys, Laura Chomette, Helene Lasolle, Olivier Monestier, Dominika Figini Kasprzyk, Vincent Detours, Sumeet Pal Singh, Serge Goldman, Samuel Refetoff & Sabine Costagliola
Published in: Nature Communications, Issue November, 2022, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-34776-7

A Modular Microfluidic Organoid Platform Using LEGO‐Like Bricks

Author(s): Daniel J. Carvalho, Anna M. Kip, Andreas Tegel, Matthias Stich, Christian Krause, Mírian Romitti, Carlotta Branca, Bart Verhoeven, Sabine Costagliola, Lorenzo Moroni, Stefan Giselbrecht
Published in: Advanced Healthcare Materials, Issue 13, 2024, Page(s) 303444, ISSN 2192-2640
Publisher: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202303444

Single-Cell Trajectory Inference Guided Enhancement of Thyroid Maturation In Vitro Using TGF-Beta Inhibition

Author(s): Mírian Romitti, Sema Elif Eski, Barbara Faria Fonseca, Pierre Gillotay, Sumeet Pal Singh, Sabine Costagliola
Published in: Frontiers in Endocrinology, Issue 12, 2021, ISSN 1664-2392
Publisher: Frontiers
DOI: 10.3389/fendo.2021.657195

CODA: a combo-Seq data analysis workflow

Author(s): Marta Nazzari, Duncan Hauser, Marcel van Herwijnen, Mírian Romitti, Daniel J Carvalho, Anna M Kip, and Florian Caiment
Published in: Briefings in Bioinformatics, Issue 24, January 2023, 2023, Page(s) 1, ISSN 1477-4054
Publisher: Oxford University Press
DOI: 10.1093/bib/bbac582

Microtopography of Immune Cells in Osteoporosis and Bone Lesions by Endocrine Disruptors

Author(s): Roberto Toni, Giusy Di Conza, Fulvio Barbaro, Nicoletta Zini, Elia Consolini, Davide Dallatana, Manuela Antoniel, Enrico Quarantini, Marco Quarantini, Sara Maioli, Celeste Angela Bruni, Lisa Elviri, Silvia Panseri, Simone Sprio, Monica Sandri, Anna Tampieri
Published in: Frontiers in Immunology, Issue 11, 2020, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2020.01737

A Computational Template for Three-Dimensional Modeling of the Vascular Scaffold of the Human Thyroid Gland

Author(s): Giulia Spaletta; Mark Sofroniou; Fulvio Barbaro; Giusy di Conza; Salvatore Mosca; Roberto Toni
Published in: Tissue Engineering Part A, Issue Volume 29, Numbers 1 and 2, 2023, 2023, Page(s) 47-57, ISSN 1937-335X
Publisher: Mary Ann Liebert, Inc.
DOI: 10.1089/ten.tea.2022.0148

Progress Toward and Challenges Remaining for Thyroid Tissue Regeneration

Author(s): Mírian Romitti, Sabine Costagliola
Published in: Endocrinology, Issue 164, 2023, Page(s) 164(10):bqad136, ISSN 1945-7170
Publisher: Endocrine Society
DOI: 10.1210/endocr/bqad136

SCREENED: A Multistage Model of Thyroid Gland Function for Screening Endocrine-Disrupting Chemicals in a Biologically Sex-Specific Manner

Author(s): Lorenzo Moroni, Fulvio Barbaro, Florian Caiment, Orla Coleman, Sabine Costagliola, Giusy Di Conza, Lisa Elviri, Stefan Giselbrecht, Christian Krause, Carlos Mota, Marta Nazzari, Stephen R. Pennington, Annette Ringwald, Monica Sandri, Simon Thomas, James Waddington, Roberto Toni
Published in: International Journal of Molecular Sciences, Issue 21/10, 2020, Page(s) 3648, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21103648

A targeted mass spectrometry method to screen collagen types I-V in the decellularized 3D extracellular matrix of the adult male rat thyroid

Author(s): Marco Alfieri, Fulvio Barbaro, Elia Consolini, Elena Bassi, Davide Dallatana, Carlo Bergonzi, Annalisa Bianchera, Ruggero Bettini, Roberto Toni, Lisa Elviri
Published in: Talanta, Issue 193, 2019, Page(s) 1-8, ISSN 0039-9140
Publisher: Elsevier BV
DOI: 10.1016/j.talanta.2018.09.087

Decellularization detergents as methdological variables in mass spectrometry of stromal matrices

Author(s): Giulia Remaggi, Fulvio Barbaro, Giusy Di Conza, Giovanna Trevisi, Carlo Bergonzi
Published in: Tissue Egineering Part C Methods, Issue Volume 28, Number 4, 2022, 2022, Page(s) 148 - 157, ISSN 1937-3384
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tec.2021.0191

Thyroid-on-a-chip: An organoid Platform for in vitro assessment of endocrine disruption

Author(s): Daniel J. Carvalho, Anna M. Kip, Mírian Romitti, Marta Nazzari, Andreas Tegel, Matthias Stich, Christian Krause, Florian Caiment, Sabine Costagliola, Lorenzo Moroni, Stefan Giselbrecht
Published in: Advances Healthcare Materials, Issue 12.8, March 2023, 2023, ISSN 1521-4095
Publisher: Wiley
DOI: 10.1002/adhm.202201555

Woven bone formation and mineralization by rat mesenchymal stromal cells imply increased expression of the intermediate filament desmin

Author(s): Giusy Di Conza, Fulvio Barbaro, Nicoletta Zini, Giulia Spaletta, Giulia Remaggi, Lisa Elviri, Salvatore Mosca, Silvio Caravelli, Massimiliano Mosca, Roberto Toni
Published in: Frontiers in Endocrinology, Issue 14, 2023, Page(s) 1-19, ISSN 1664-2392
Publisher: Frontiers Endocrinology
DOI: 10.3389/fendo.2023.1234569

Investigation of the effects of phthalates on in vitro thyroid models with RNA-Seq and ATAC-Seq

Author(s): Marta Nazzari, Mírian Romitti, Duncan Hauser, Daniel J. Carvalho, Stefan Giselbrecht, Lorenzo Moroni, Sabine Costagliola, Florian Caiment
Published in: Frontiers in Endocrinology, Issue 14, 2023, 2023, ISSN 1664-2392
Publisher: Frontiers Media S.A
DOI: 10.3389/fendo.2023.1200211

Impact of benzo[a]pyrene, PCB153 and sex hormones on human ESC-Derived thyroid follicles using single cell transcriptomics

Author(s): Marta Nazzari, Mírian Romitti, Anna M. Kip, Rick Kamps, Sabine Costagliola, Twan van de Beucken, Lorenzo Moroni, Florian Caiment
Published in: Environment International, Issue 188, 2024, Page(s) 108748, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2024.108748

Conference proceedings (1)

Generation of human thyroid organoids from embryonic stem cells to rescue hypothyroidism

Author(s): Mírian Romitti, Adrien Tourneur, Barbara de Faria da Fonseca, Gilles Doumont, Pierre Gillotay, Xiao-Hui Liao, Sema Elif Eski, Gaetan Van Simaeys, Laura Chomette, Helene Lasolle, Olivier Monestier, Dominika Figini Kasprzyk, Vincent Detours, Sumeet Pal Singh, Serge Goldman, Samuel Refetoff & Sabine Costagliola
Published in: European Thyroid Association Congress - Endocrine Abstracts, Issue 1, 2022
Publisher: bioscientifica

Non-peer reviewed articles (1)

Clamping strategies for organ-on-a-chip devices

Author(s): Daniel J. Carvalho, Lorenzo Moroni, Stefan Giselbrecht
Published in: Nature Reviews Materials, Issue 19, January 2023, 2023, ISSN 1476-4687
Publisher: Nature
DOI: 10.1038/s41578-022-00523-z