A multistage model of thyroid gland function for screening endocrine-disrupting chemicals in a biologically sex-specific manner

Risultati finali

Transcriptomic datasets of effect of EDs on thyroid cells

This deliverable consists of a report describing the transcriptomic data obtained in the 3D in vitro models.

3-5 AOPs for ED-mediated disruption of thyroid function completed in AOP Wiki

This deliverable consists of the submission on the OECD Environmental Health and Safety AOP Wiki of up to 3 AOPs describing the effects of ED’s on thyroid function in mammals in vivo.

Proteomic and datasets of effect of EDs on thyroid cells

This deliverable consists of a report describing the proteomics data obtained in the 3D in vitro models.

Individualised press release for every partner

Edition of one press release to communicate about the project objectives, approach and results. The press release will be translated into the language of each partner country.

Launch of public website & Twitter account

SCREENED website with project information, news and results allowing interactions with third parties.

Pubblicazioni

Liquid chromatography – mass spectrometry, biomaterials and 3D printing in analytical applications

Autori: Giulia Remaggi
Pubblicato in: PhD Thesis, 2023
Editore: University of Parma, Italy

"A bioinformatic evaluation of endocrine disruptor – dependent proteomic profile of rat thyroid cells tested with an EU Joint Research Centre-submitted in vitro assay: Horizon Project SCREENED #825745"

Autori: Francesca Pia Quartulli
Pubblicato in: 2024, Pagina/e 1-96
Editore: University of Parma, Parma, Italy URL https://www.unipr.it/

"An innovative European Joint Research Center-submitted in vitro assay for screening Endocrine Disruptors effects on thyroid cell function: Horizon Project SCREENED #825745"

Autori: Elena Caddeo
Pubblicato in: PhD Thesis, 2023
Editore: University of Parma, Italy

Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism

Autori: Mírian Romitti, Adrien Tourneur, Barbara de Faria da Fonseca, Gilles Doumont, Pierre Gillotay, Xiao-Hui Liao, Sema Elif Eski, Gaetan Van Simaeys, Laura Chomette, Helene Lasolle, Olivier Monestier, Dominika Figini Kasprzyk, Vincent Detours, Sumeet Pal Singh, Serge Goldman, Samuel Refetoff & Sabine Costagliola
Pubblicato in: Nature Communications, Numero November, 2022, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-34776-7

A Modular Microfluidic Organoid Platform Using LEGO‐Like Bricks

Autori: Daniel J. Carvalho, Anna M. Kip, Andreas Tegel, Matthias Stich, Christian Krause, Mírian Romitti, Carlotta Branca, Bart Verhoeven, Sabine Costagliola, Lorenzo Moroni, Stefan Giselbrecht
Pubblicato in: Advanced Healthcare Materials, Numero 13, 2024, Pagina/e 303444, ISSN 2192-2640
Editore: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202303444

Single-Cell Trajectory Inference Guided Enhancement of Thyroid Maturation In Vitro Using TGF-Beta Inhibition

Autori: Mírian Romitti, Sema Elif Eski, Barbara Faria Fonseca, Pierre Gillotay, Sumeet Pal Singh, Sabine Costagliola
Pubblicato in: Frontiers in Endocrinology, Numero 12, 2021, ISSN 1664-2392
Editore: Frontiers
DOI: 10.3389/fendo.2021.657195

CODA: a combo-Seq data analysis workflow

Autori: Marta Nazzari, Duncan Hauser, Marcel van Herwijnen, Mírian Romitti, Daniel J Carvalho, Anna M Kip, and Florian Caiment
Pubblicato in: Briefings in Bioinformatics, Numero 24, January 2023, 2023, Pagina/e 1, ISSN 1477-4054
Editore: Oxford University Press
DOI: 10.1093/bib/bbac582

Microtopography of Immune Cells in Osteoporosis and Bone Lesions by Endocrine Disruptors

Autori: Roberto Toni, Giusy Di Conza, Fulvio Barbaro, Nicoletta Zini, Elia Consolini, Davide Dallatana, Manuela Antoniel, Enrico Quarantini, Marco Quarantini, Sara Maioli, Celeste Angela Bruni, Lisa Elviri, Silvia Panseri, Simone Sprio, Monica Sandri, Anna Tampieri
Pubblicato in: Frontiers in Immunology, Numero 11, 2020, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2020.01737

A Computational Template for Three-Dimensional Modeling of the Vascular Scaffold of the Human Thyroid Gland

Autori: Giulia Spaletta; Mark Sofroniou; Fulvio Barbaro; Giusy di Conza; Salvatore Mosca; Roberto Toni
Pubblicato in: Tissue Engineering Part A, Numero Volume 29, Numbers 1 and 2, 2023, 2023, Pagina/e 47-57, ISSN 1937-335X
Editore: Mary Ann Liebert, Inc.
DOI: 10.1089/ten.tea.2022.0148

Progress Toward and Challenges Remaining for Thyroid Tissue Regeneration

Autori: Mírian Romitti, Sabine Costagliola
Pubblicato in: Endocrinology, Numero 164, 2023, Pagina/e 164(10):bqad136, ISSN 1945-7170
Editore: Endocrine Society
DOI: 10.1210/endocr/bqad136

SCREENED: A Multistage Model of Thyroid Gland Function for Screening Endocrine-Disrupting Chemicals in a Biologically Sex-Specific Manner

Autori: Lorenzo Moroni, Fulvio Barbaro, Florian Caiment, Orla Coleman, Sabine Costagliola, Giusy Di Conza, Lisa Elviri, Stefan Giselbrecht, Christian Krause, Carlos Mota, Marta Nazzari, Stephen R. Pennington, Annette Ringwald, Monica Sandri, Simon Thomas, James Waddington, Roberto Toni
Pubblicato in: International Journal of Molecular Sciences, Numero 21/10, 2020, Pagina/e 3648, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21103648

A targeted mass spectrometry method to screen collagen types I-V in the decellularized 3D extracellular matrix of the adult male rat thyroid

Autori: Marco Alfieri, Fulvio Barbaro, Elia Consolini, Elena Bassi, Davide Dallatana, Carlo Bergonzi, Annalisa Bianchera, Ruggero Bettini, Roberto Toni, Lisa Elviri
Pubblicato in: Talanta, Numero 193, 2019, Pagina/e 1-8, ISSN 0039-9140
Editore: Elsevier BV
DOI: 10.1016/j.talanta.2018.09.087

Decellularization detergents as methdological variables in mass spectrometry of stromal matrices

Autori: Giulia Remaggi, Fulvio Barbaro, Giusy Di Conza, Giovanna Trevisi, Carlo Bergonzi
Pubblicato in: Tissue Egineering Part C Methods, Numero Volume 28, Number 4, 2022, 2022, Pagina/e 148 - 157, ISSN 1937-3384
Editore: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tec.2021.0191

Thyroid-on-a-chip: An organoid Platform for in vitro assessment of endocrine disruption

Autori: Daniel J. Carvalho, Anna M. Kip, Mírian Romitti, Marta Nazzari, Andreas Tegel, Matthias Stich, Christian Krause, Florian Caiment, Sabine Costagliola, Lorenzo Moroni, Stefan Giselbrecht
Pubblicato in: Advances Healthcare Materials, Numero 12.8, March 2023, 2023, ISSN 1521-4095
Editore: Wiley
DOI: 10.1002/adhm.202201555

Woven bone formation and mineralization by rat mesenchymal stromal cells imply increased expression of the intermediate filament desmin

Autori: Giusy Di Conza, Fulvio Barbaro, Nicoletta Zini, Giulia Spaletta, Giulia Remaggi, Lisa Elviri, Salvatore Mosca, Silvio Caravelli, Massimiliano Mosca, Roberto Toni
Pubblicato in: Frontiers in Endocrinology, Numero 14, 2023, Pagina/e 1-19, ISSN 1664-2392
Editore: Frontiers Endocrinology
DOI: 10.3389/fendo.2023.1234569

Investigation of the effects of phthalates on in vitro thyroid models with RNA-Seq and ATAC-Seq

Autori: Marta Nazzari, Mírian Romitti, Duncan Hauser, Daniel J. Carvalho, Stefan Giselbrecht, Lorenzo Moroni, Sabine Costagliola, Florian Caiment
Pubblicato in: Frontiers in Endocrinology, Numero 14, 2023, 2023, ISSN 1664-2392
Editore: Frontiers Media S.A
DOI: 10.3389/fendo.2023.1200211

Impact of benzo[a]pyrene, PCB153 and sex hormones on human ESC-Derived thyroid follicles using single cell transcriptomics

Autori: Marta Nazzari, Mírian Romitti, Anna M. Kip, Rick Kamps, Sabine Costagliola, Twan van de Beucken, Lorenzo Moroni, Florian Caiment
Pubblicato in: Environment International, Numero 188, 2024, Pagina/e 108748, ISSN 0160-4120
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2024.108748

Generation of human thyroid organoids from embryonic stem cells to rescue hypothyroidism

Autori: Mírian Romitti, Adrien Tourneur, Barbara de Faria da Fonseca, Gilles Doumont, Pierre Gillotay, Xiao-Hui Liao, Sema Elif Eski, Gaetan Van Simaeys, Laura Chomette, Helene Lasolle, Olivier Monestier, Dominika Figini Kasprzyk, Vincent Detours, Sumeet Pal Singh, Serge Goldman, Samuel Refetoff & Sabine Costagliola
Pubblicato in: European Thyroid Association Congress - Endocrine Abstracts, Numero 1, 2022
Editore: bioscientifica

Clamping strategies for organ-on-a-chip devices

Autori: Daniel J. Carvalho, Lorenzo Moroni, Stefan Giselbrecht
Pubblicato in: Nature Reviews Materials, Numero 19, January 2023, 2023, ISSN 1476-4687
Editore: Nature
DOI: 10.1038/s41578-022-00523-z

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