A multistage model of thyroid gland function for screening endocrine-disrupting chemicals in a biologically sex-specific manner

Informacje na temat projektu

SCREENED

Identyfikator umowy o grant: 825745

DOI

10.3030/825745

Projekt został zamknięty

Data podpisania przez KE 26 Listopada 2018

Data rozpoczęcia 1 Stycznia 2019

Data zakończenia 30 Czerwca 2024

Finansowanie w ramach

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Koszt całkowity

€ 5 655 088,75

Wkład UE

€ 5 655 088,75

Koordynowany przez

UNIVERSITEIT MAASTRICHT
Netherlands

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Documents, reports (3)

Transcriptomic datasets of effect of EDs on thyroid cells

This deliverable consists of a report describing the transcriptomic data obtained in the 3D in vitro models.

3-5 AOPs for ED-mediated disruption of thyroid function completed in AOP Wiki

This deliverable consists of the submission on the OECD Environmental Health and Safety AOP Wiki of up to 3 AOPs describing the effects of ED’s on thyroid function in mammals in vivo.

Proteomic and datasets of effect of EDs on thyroid cells

This deliverable consists of a report describing the proteomics data obtained in the 3D in vitro models.

Websites, patent fillings, videos etc. (2)

Individualised press release for every partner

Edition of one press release to communicate about the project objectives, approach and results. The press release will be translated into the language of each partner country.

Launch of public website & Twitter account

SCREENED website with project information, news and results allowing interactions with third parties.

Publikacje

Thesis and dissertations (3)

Liquid chromatography – mass spectrometry, biomaterials and 3D printing in analytical applications

Autorzy: Giulia Remaggi
Opublikowane w: PhD Thesis, 2023
Wydawca: University of Parma, Italy

"A bioinformatic evaluation of endocrine disruptor – dependent proteomic profile of rat thyroid cells tested with an EU Joint Research Centre-submitted in vitro assay: Horizon Project SCREENED #825745"

Autorzy: Francesca Pia Quartulli
Opublikowane w: 2024, Strona(/y) 1-96
Wydawca: University of Parma, Parma, Italy URL https://www.unipr.it/

"An innovative European Joint Research Center-submitted in vitro assay for screening Endocrine Disruptors effects on thyroid cell function: Horizon Project SCREENED #825745"

Autorzy: Elena Caddeo
Opublikowane w: PhD Thesis, 2023
Wydawca: University of Parma, Italy

Peer reviewed articles (14)

Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism

Autorzy: Mírian Romitti, Adrien Tourneur, Barbara de Faria da Fonseca, Gilles Doumont, Pierre Gillotay, Xiao-Hui Liao, Sema Elif Eski, Gaetan Van Simaeys, Laura Chomette, Helene Lasolle, Olivier Monestier, Dominika Figini Kasprzyk, Vincent Detours, Sumeet Pal Singh, Serge Goldman, Samuel Refetoff & Sabine Costagliola
Opublikowane w: Nature Communications, Numer November, 2022, 2022, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-022-34776-7

A Modular Microfluidic Organoid Platform Using LEGO‐Like Bricks

Autorzy: Daniel J. Carvalho, Anna M. Kip, Andreas Tegel, Matthias Stich, Christian Krause, Mírian Romitti, Carlotta Branca, Bart Verhoeven, Sabine Costagliola, Lorenzo Moroni, Stefan Giselbrecht
Opublikowane w: Advanced Healthcare Materials, Numer 13, 2024, Strona(/y) 303444, ISSN 2192-2640
Wydawca: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202303444

Single-Cell Trajectory Inference Guided Enhancement of Thyroid Maturation In Vitro Using TGF-Beta Inhibition

Autorzy: Mírian Romitti, Sema Elif Eski, Barbara Faria Fonseca, Pierre Gillotay, Sumeet Pal Singh, Sabine Costagliola
Opublikowane w: Frontiers in Endocrinology, Numer 12, 2021, ISSN 1664-2392
Wydawca: Frontiers
DOI: 10.3389/fendo.2021.657195

CODA: a combo-Seq data analysis workflow

Autorzy: Marta Nazzari, Duncan Hauser, Marcel van Herwijnen, Mírian Romitti, Daniel J Carvalho, Anna M Kip, and Florian Caiment
Opublikowane w: Briefings in Bioinformatics, Numer 24, January 2023, 2023, Strona(/y) 1, ISSN 1477-4054
Wydawca: Oxford University Press
DOI: 10.1093/bib/bbac582

Microtopography of Immune Cells in Osteoporosis and Bone Lesions by Endocrine Disruptors

Autorzy: Roberto Toni, Giusy Di Conza, Fulvio Barbaro, Nicoletta Zini, Elia Consolini, Davide Dallatana, Manuela Antoniel, Enrico Quarantini, Marco Quarantini, Sara Maioli, Celeste Angela Bruni, Lisa Elviri, Silvia Panseri, Simone Sprio, Monica Sandri, Anna Tampieri
Opublikowane w: Frontiers in Immunology, Numer 11, 2020, ISSN 1664-3224
Wydawca: Frontiers
DOI: 10.3389/fimmu.2020.01737

A Computational Template for Three-Dimensional Modeling of the Vascular Scaffold of the Human Thyroid Gland

Autorzy: Giulia Spaletta; Mark Sofroniou; Fulvio Barbaro; Giusy di Conza; Salvatore Mosca; Roberto Toni
Opublikowane w: Tissue Engineering Part A, Numer Volume 29, Numbers 1 and 2, 2023, 2023, Strona(/y) 47-57, ISSN 1937-335X
Wydawca: Mary Ann Liebert, Inc.
DOI: 10.1089/ten.tea.2022.0148

Progress Toward and Challenges Remaining for Thyroid Tissue Regeneration

Autorzy: Mírian Romitti, Sabine Costagliola
Opublikowane w: Endocrinology, Numer 164, 2023, Strona(/y) 164(10):bqad136, ISSN 1945-7170
Wydawca: Endocrine Society
DOI: 10.1210/endocr/bqad136

SCREENED: A Multistage Model of Thyroid Gland Function for Screening Endocrine-Disrupting Chemicals in a Biologically Sex-Specific Manner

Autorzy: Lorenzo Moroni, Fulvio Barbaro, Florian Caiment, Orla Coleman, Sabine Costagliola, Giusy Di Conza, Lisa Elviri, Stefan Giselbrecht, Christian Krause, Carlos Mota, Marta Nazzari, Stephen R. Pennington, Annette Ringwald, Monica Sandri, Simon Thomas, James Waddington, Roberto Toni
Opublikowane w: International Journal of Molecular Sciences, Numer 21/10, 2020, Strona(/y) 3648, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21103648

A targeted mass spectrometry method to screen collagen types I-V in the decellularized 3D extracellular matrix of the adult male rat thyroid

Autorzy: Marco Alfieri, Fulvio Barbaro, Elia Consolini, Elena Bassi, Davide Dallatana, Carlo Bergonzi, Annalisa Bianchera, Ruggero Bettini, Roberto Toni, Lisa Elviri
Opublikowane w: Talanta, Numer 193, 2019, Strona(/y) 1-8, ISSN 0039-9140
Wydawca: Elsevier BV
DOI: 10.1016/j.talanta.2018.09.087

Decellularization detergents as methdological variables in mass spectrometry of stromal matrices

Autorzy: Giulia Remaggi, Fulvio Barbaro, Giusy Di Conza, Giovanna Trevisi, Carlo Bergonzi
Opublikowane w: Tissue Egineering Part C Methods, Numer Volume 28, Number 4, 2022, 2022, Strona(/y) 148 - 157, ISSN 1937-3384
Wydawca: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tec.2021.0191

Thyroid-on-a-chip: An organoid Platform for in vitro assessment of endocrine disruption

Autorzy: Daniel J. Carvalho, Anna M. Kip, Mírian Romitti, Marta Nazzari, Andreas Tegel, Matthias Stich, Christian Krause, Florian Caiment, Sabine Costagliola, Lorenzo Moroni, Stefan Giselbrecht
Opublikowane w: Advances Healthcare Materials, Numer 12.8, March 2023, 2023, ISSN 1521-4095
Wydawca: Wiley
DOI: 10.1002/adhm.202201555

Woven bone formation and mineralization by rat mesenchymal stromal cells imply increased expression of the intermediate filament desmin

Autorzy: Giusy Di Conza, Fulvio Barbaro, Nicoletta Zini, Giulia Spaletta, Giulia Remaggi, Lisa Elviri, Salvatore Mosca, Silvio Caravelli, Massimiliano Mosca, Roberto Toni
Opublikowane w: Frontiers in Endocrinology, Numer 14, 2023, Strona(/y) 1-19, ISSN 1664-2392
Wydawca: Frontiers Endocrinology
DOI: 10.3389/fendo.2023.1234569

Investigation of the effects of phthalates on in vitro thyroid models with RNA-Seq and ATAC-Seq

Autorzy: Marta Nazzari, Mírian Romitti, Duncan Hauser, Daniel J. Carvalho, Stefan Giselbrecht, Lorenzo Moroni, Sabine Costagliola, Florian Caiment
Opublikowane w: Frontiers in Endocrinology, Numer 14, 2023, 2023, ISSN 1664-2392
Wydawca: Frontiers Media S.A
DOI: 10.3389/fendo.2023.1200211

Impact of benzo[a]pyrene, PCB153 and sex hormones on human ESC-Derived thyroid follicles using single cell transcriptomics

Autorzy: Marta Nazzari, Mírian Romitti, Anna M. Kip, Rick Kamps, Sabine Costagliola, Twan van de Beucken, Lorenzo Moroni, Florian Caiment
Opublikowane w: Environment International, Numer 188, 2024, Strona(/y) 108748, ISSN 0160-4120
Wydawca: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2024.108748

Conference proceedings (1)

Generation of human thyroid organoids from embryonic stem cells to rescue hypothyroidism

Autorzy: Mírian Romitti, Adrien Tourneur, Barbara de Faria da Fonseca, Gilles Doumont, Pierre Gillotay, Xiao-Hui Liao, Sema Elif Eski, Gaetan Van Simaeys, Laura Chomette, Helene Lasolle, Olivier Monestier, Dominika Figini Kasprzyk, Vincent Detours, Sumeet Pal Singh, Serge Goldman, Samuel Refetoff & Sabine Costagliola
Opublikowane w: European Thyroid Association Congress - Endocrine Abstracts, Numer 1, 2022
Wydawca: bioscientifica

Non-peer reviewed articles (1)

Clamping strategies for organ-on-a-chip devices

Autorzy: Daniel J. Carvalho, Lorenzo Moroni, Stefan Giselbrecht
Opublikowane w: Nature Reviews Materials, Numer 19, January 2023, 2023, ISSN 1476-4687
Wydawca: Nature
DOI: 10.1038/s41578-022-00523-z