A multistage model of thyroid gland function for screening endocrine-disrupting chemicals in a biologically sex-specific manner

Información del proyecto

SCREENED

Identificador del acuerdo de subvención: 825745

DOI

10.3030/825745

Proyecto cerrado

Fecha de la firma de la CE 26 Noviembre 2018

Fecha de inicio 1 Enero 2019

Fecha de finalización 30 Junio 2024

Financiado con arreglo a

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coste total

€ 5 655 088,75

Aportación de la UE

€ 5 655 088,75

Coordinado por

UNIVERSITEIT MAASTRICHT
Netherlands

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (3)

Transcriptomic datasets of effect of EDs on thyroid cells

This deliverable consists of a report describing the transcriptomic data obtained in the 3D in vitro models.

3-5 AOPs for ED-mediated disruption of thyroid function completed in AOP Wiki

This deliverable consists of the submission on the OECD Environmental Health and Safety AOP Wiki of up to 3 AOPs describing the effects of ED’s on thyroid function in mammals in vivo.

Proteomic and datasets of effect of EDs on thyroid cells

This deliverable consists of a report describing the proteomics data obtained in the 3D in vitro models.

Websites, patent fillings, videos etc. (2)

Individualised press release for every partner

Edition of one press release to communicate about the project objectives, approach and results. The press release will be translated into the language of each partner country.

Launch of public website & Twitter account

SCREENED website with project information, news and results allowing interactions with third parties.

Publicaciones

Thesis and dissertations (3)

Liquid chromatography – mass spectrometry, biomaterials and 3D printing in analytical applications

Autores: Giulia Remaggi
Publicado en: PhD Thesis, 2023
Editor: University of Parma, Italy

"A bioinformatic evaluation of endocrine disruptor – dependent proteomic profile of rat thyroid cells tested with an EU Joint Research Centre-submitted in vitro assay: Horizon Project SCREENED #825745"

Autores: Francesca Pia Quartulli
Publicado en: 2024, Página(s) 1-96
Editor: University of Parma, Parma, Italy URL https://www.unipr.it/

"An innovative European Joint Research Center-submitted in vitro assay for screening Endocrine Disruptors effects on thyroid cell function: Horizon Project SCREENED #825745"

Autores: Elena Caddeo
Publicado en: PhD Thesis, 2023
Editor: University of Parma, Italy

Peer reviewed articles (14)

Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism

Autores: Mírian Romitti, Adrien Tourneur, Barbara de Faria da Fonseca, Gilles Doumont, Pierre Gillotay, Xiao-Hui Liao, Sema Elif Eski, Gaetan Van Simaeys, Laura Chomette, Helene Lasolle, Olivier Monestier, Dominika Figini Kasprzyk, Vincent Detours, Sumeet Pal Singh, Serge Goldman, Samuel Refetoff & Sabine Costagliola
Publicado en: Nature Communications, Edición November, 2022, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-34776-7

A Modular Microfluidic Organoid Platform Using LEGO‐Like Bricks

Autores: Daniel J. Carvalho, Anna M. Kip, Andreas Tegel, Matthias Stich, Christian Krause, Mírian Romitti, Carlotta Branca, Bart Verhoeven, Sabine Costagliola, Lorenzo Moroni, Stefan Giselbrecht
Publicado en: Advanced Healthcare Materials, Edición 13, 2024, Página(s) 303444, ISSN 2192-2640
Editor: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202303444

Single-Cell Trajectory Inference Guided Enhancement of Thyroid Maturation In Vitro Using TGF-Beta Inhibition

Autores: Mírian Romitti, Sema Elif Eski, Barbara Faria Fonseca, Pierre Gillotay, Sumeet Pal Singh, Sabine Costagliola
Publicado en: Frontiers in Endocrinology, Edición 12, 2021, ISSN 1664-2392
Editor: Frontiers
DOI: 10.3389/fendo.2021.657195

CODA: a combo-Seq data analysis workflow

Autores: Marta Nazzari, Duncan Hauser, Marcel van Herwijnen, Mírian Romitti, Daniel J Carvalho, Anna M Kip, and Florian Caiment
Publicado en: Briefings in Bioinformatics, Edición 24, January 2023, 2023, Página(s) 1, ISSN 1477-4054
Editor: Oxford University Press
DOI: 10.1093/bib/bbac582

Microtopography of Immune Cells in Osteoporosis and Bone Lesions by Endocrine Disruptors

Autores: Roberto Toni, Giusy Di Conza, Fulvio Barbaro, Nicoletta Zini, Elia Consolini, Davide Dallatana, Manuela Antoniel, Enrico Quarantini, Marco Quarantini, Sara Maioli, Celeste Angela Bruni, Lisa Elviri, Silvia Panseri, Simone Sprio, Monica Sandri, Anna Tampieri
Publicado en: Frontiers in Immunology, Edición 11, 2020, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2020.01737

A Computational Template for Three-Dimensional Modeling of the Vascular Scaffold of the Human Thyroid Gland

Autores: Giulia Spaletta; Mark Sofroniou; Fulvio Barbaro; Giusy di Conza; Salvatore Mosca; Roberto Toni
Publicado en: Tissue Engineering Part A, Edición Volume 29, Numbers 1 and 2, 2023, 2023, Página(s) 47-57, ISSN 1937-335X
Editor: Mary Ann Liebert, Inc.
DOI: 10.1089/ten.tea.2022.0148

Progress Toward and Challenges Remaining for Thyroid Tissue Regeneration

Autores: Mírian Romitti, Sabine Costagliola
Publicado en: Endocrinology, Edición 164, 2023, Página(s) 164(10):bqad136, ISSN 1945-7170
Editor: Endocrine Society
DOI: 10.1210/endocr/bqad136

SCREENED: A Multistage Model of Thyroid Gland Function for Screening Endocrine-Disrupting Chemicals in a Biologically Sex-Specific Manner

Autores: Lorenzo Moroni, Fulvio Barbaro, Florian Caiment, Orla Coleman, Sabine Costagliola, Giusy Di Conza, Lisa Elviri, Stefan Giselbrecht, Christian Krause, Carlos Mota, Marta Nazzari, Stephen R. Pennington, Annette Ringwald, Monica Sandri, Simon Thomas, James Waddington, Roberto Toni
Publicado en: International Journal of Molecular Sciences, Edición 21/10, 2020, Página(s) 3648, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21103648

A targeted mass spectrometry method to screen collagen types I-V in the decellularized 3D extracellular matrix of the adult male rat thyroid

Autores: Marco Alfieri, Fulvio Barbaro, Elia Consolini, Elena Bassi, Davide Dallatana, Carlo Bergonzi, Annalisa Bianchera, Ruggero Bettini, Roberto Toni, Lisa Elviri
Publicado en: Talanta, Edición 193, 2019, Página(s) 1-8, ISSN 0039-9140
Editor: Elsevier BV
DOI: 10.1016/j.talanta.2018.09.087

Decellularization detergents as methdological variables in mass spectrometry of stromal matrices

Autores: Giulia Remaggi, Fulvio Barbaro, Giusy Di Conza, Giovanna Trevisi, Carlo Bergonzi
Publicado en: Tissue Egineering Part C Methods, Edición Volume 28, Number 4, 2022, 2022, Página(s) 148 - 157, ISSN 1937-3384
Editor: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tec.2021.0191

Thyroid-on-a-chip: An organoid Platform for in vitro assessment of endocrine disruption

Autores: Daniel J. Carvalho, Anna M. Kip, Mírian Romitti, Marta Nazzari, Andreas Tegel, Matthias Stich, Christian Krause, Florian Caiment, Sabine Costagliola, Lorenzo Moroni, Stefan Giselbrecht
Publicado en: Advances Healthcare Materials, Edición 12.8, March 2023, 2023, ISSN 1521-4095
Editor: Wiley
DOI: 10.1002/adhm.202201555

Woven bone formation and mineralization by rat mesenchymal stromal cells imply increased expression of the intermediate filament desmin

Autores: Giusy Di Conza, Fulvio Barbaro, Nicoletta Zini, Giulia Spaletta, Giulia Remaggi, Lisa Elviri, Salvatore Mosca, Silvio Caravelli, Massimiliano Mosca, Roberto Toni
Publicado en: Frontiers in Endocrinology, Edición 14, 2023, Página(s) 1-19, ISSN 1664-2392
Editor: Frontiers Endocrinology
DOI: 10.3389/fendo.2023.1234569

Investigation of the effects of phthalates on in vitro thyroid models with RNA-Seq and ATAC-Seq

Autores: Marta Nazzari, Mírian Romitti, Duncan Hauser, Daniel J. Carvalho, Stefan Giselbrecht, Lorenzo Moroni, Sabine Costagliola, Florian Caiment
Publicado en: Frontiers in Endocrinology, Edición 14, 2023, 2023, ISSN 1664-2392
Editor: Frontiers Media S.A
DOI: 10.3389/fendo.2023.1200211

Impact of benzo[a]pyrene, PCB153 and sex hormones on human ESC-Derived thyroid follicles using single cell transcriptomics

Autores: Marta Nazzari, Mírian Romitti, Anna M. Kip, Rick Kamps, Sabine Costagliola, Twan van de Beucken, Lorenzo Moroni, Florian Caiment
Publicado en: Environment International, Edición 188, 2024, Página(s) 108748, ISSN 0160-4120
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2024.108748

Conference proceedings (1)

Generation of human thyroid organoids from embryonic stem cells to rescue hypothyroidism

Autores: Mírian Romitti, Adrien Tourneur, Barbara de Faria da Fonseca, Gilles Doumont, Pierre Gillotay, Xiao-Hui Liao, Sema Elif Eski, Gaetan Van Simaeys, Laura Chomette, Helene Lasolle, Olivier Monestier, Dominika Figini Kasprzyk, Vincent Detours, Sumeet Pal Singh, Serge Goldman, Samuel Refetoff & Sabine Costagliola
Publicado en: European Thyroid Association Congress - Endocrine Abstracts, Edición 1, 2022
Editor: bioscientifica

Non-peer reviewed articles (1)

Clamping strategies for organ-on-a-chip devices

Autores: Daniel J. Carvalho, Lorenzo Moroni, Stefan Giselbrecht
Publicado en: Nature Reviews Materials, Edición 19, January 2023, 2023, ISSN 1476-4687
Editor: Nature
DOI: 10.1038/s41578-022-00523-z