A multistage model of thyroid gland function for screening endocrine-disrupting chemicals in a biologically sex-specific manner

Leistungen

Transcriptomic datasets of effect of EDs on thyroid cells

This deliverable consists of a report describing the transcriptomic data obtained in the 3D in vitro models.

Proteomic and datasets of effect of EDs on thyroid cells

This deliverable consists of a report describing the proteomics data obtained in the 3D in vitro models.

Individualised press release for every partner

Edition of one press release to communicate about the project objectives, approach and results. The press release will be translated into the language of each partner country.

Launch of public website & Twitter account

SCREENED website with project information, news and results allowing interactions with third parties.

Veröffentlichungen

Liquid chromatography – mass spectrometry, biomaterials and 3D printing in analytical applications

Autoren: Giulia Remaggi
Veröffentlicht in: PhD Thesis, 2023
Herausgeber: University of Parma, Italy

"An innovative European Joint Research Center-submitted in vitro assay for screening Endocrine Disruptors effects on thyroid cell function: Horizon Project SCREENED #825745"

Autoren: Elena Caddeo
Veröffentlicht in: PhD Thesis, 2023
Herausgeber: University of Parma, Italy

Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism

Autoren: Mírian Romitti, Adrien Tourneur, Barbara de Faria da Fonseca, Gilles Doumont, Pierre Gillotay, Xiao-Hui Liao, Sema Elif Eski, Gaetan Van Simaeys, Laura Chomette, Helene Lasolle, Olivier Monestier, Dominika Figini Kasprzyk, Vincent Detours, Sumeet Pal Singh, Serge Goldman, Samuel Refetoff & Sabine Costagliola
Veröffentlicht in: Nature Communications, Ausgabe November, 2022, 2022, ISSN 2041-1723
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41467-022-34776-7

A Modular Microfluidic Organoid Platform Using LEGO‐Like Bricks

Autoren: Daniel J. Carvalho, Anna M. Kip, Andreas Tegel, Matthias Stich, Christian Krause, Mírian Romitti, Carlotta Branca, Bart Verhoeven, Sabine Costagliola, Lorenzo Moroni, Stefan Giselbrecht
Veröffentlicht in: Advanced Healthcare Materials, Ausgabe 13, 2024, Seite(n) 303444, ISSN 2192-2640
Herausgeber: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202303444

Single-Cell Trajectory Inference Guided Enhancement of Thyroid Maturation In Vitro Using TGF-Beta Inhibition

Autoren: Mírian Romitti, Sema Elif Eski, Barbara Faria Fonseca, Pierre Gillotay, Sumeet Pal Singh, Sabine Costagliola
Veröffentlicht in: Frontiers in Endocrinology, Ausgabe 12, 2021, ISSN 1664-2392
Herausgeber: Frontiers
DOI: 10.3389/fendo.2021.657195

CODA: a combo-Seq data analysis workflow

Autoren: Marta Nazzari, Duncan Hauser, Marcel van Herwijnen, Mírian Romitti, Daniel J Carvalho, Anna M Kip, and Florian Caiment
Veröffentlicht in: Briefings in Bioinformatics, Ausgabe 24, January 2023, 2023, Seite(n) 1, ISSN 1477-4054
Herausgeber: Oxford University Press
DOI: 10.1093/bib/bbac582

Microtopography of Immune Cells in Osteoporosis and Bone Lesions by Endocrine Disruptors

Autoren: Roberto Toni, Giusy Di Conza, Fulvio Barbaro, Nicoletta Zini, Elia Consolini, Davide Dallatana, Manuela Antoniel, Enrico Quarantini, Marco Quarantini, Sara Maioli, Celeste Angela Bruni, Lisa Elviri, Silvia Panseri, Simone Sprio, Monica Sandri, Anna Tampieri
Veröffentlicht in: Frontiers in Immunology, Ausgabe 11, 2020, ISSN 1664-3224
Herausgeber: Frontiers
DOI: 10.3389/fimmu.2020.01737

A Computational Template for Three-Dimensional Modeling of the Vascular Scaffold of the Human Thyroid Gland

Autoren: Giulia Spaletta; Mark Sofroniou; Fulvio Barbaro; Giusy di Conza; Salvatore Mosca; Roberto Toni
Veröffentlicht in: Tissue Engineering Part A, Ausgabe Volume 29, Numbers 1 and 2, 2023, 2023, Seite(n) 47-57, ISSN 1937-335X
Herausgeber: Mary Ann Liebert, Inc.
DOI: 10.1089/ten.tea.2022.0148

Progress Toward and Challenges Remaining for Thyroid Tissue Regeneration

Autoren: Mírian Romitti, Sabine Costagliola
Veröffentlicht in: Endocrinology, Ausgabe 164, 2023, Seite(n) 164(10):bqad136, ISSN 1945-7170
Herausgeber: Endocrine Society
DOI: 10.1210/endocr/bqad136

SCREENED: A Multistage Model of Thyroid Gland Function for Screening Endocrine-Disrupting Chemicals in a Biologically Sex-Specific Manner

Autoren: Lorenzo Moroni, Fulvio Barbaro, Florian Caiment, Orla Coleman, Sabine Costagliola, Giusy Di Conza, Lisa Elviri, Stefan Giselbrecht, Christian Krause, Carlos Mota, Marta Nazzari, Stephen R. Pennington, Annette Ringwald, Monica Sandri, Simon Thomas, James Waddington, Roberto Toni
Veröffentlicht in: International Journal of Molecular Sciences, Ausgabe 21/10, 2020, Seite(n) 3648, ISSN 1422-0067
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21103648

A targeted mass spectrometry method to screen collagen types I-V in the decellularized 3D extracellular matrix of the adult male rat thyroid

Autoren: Marco Alfieri, Fulvio Barbaro, Elia Consolini, Elena Bassi, Davide Dallatana, Carlo Bergonzi, Annalisa Bianchera, Ruggero Bettini, Roberto Toni, Lisa Elviri
Veröffentlicht in: Talanta, Ausgabe 193, 2019, Seite(n) 1-8, ISSN 0039-9140
Herausgeber: Elsevier BV
DOI: 10.1016/j.talanta.2018.09.087

Decellularization detergents as methdological variables in mass spectrometry of stromal matrices

Autoren: Giulia Remaggi, Fulvio Barbaro, Giusy Di Conza, Giovanna Trevisi, Carlo Bergonzi
Veröffentlicht in: Tissue Egineering Part C Methods, Ausgabe Volume 28, Number 4, 2022, 2022, Seite(n) 148 - 157, ISSN 1937-3384
Herausgeber: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tec.2021.0191

Thyroid-on-a-chip: An organoid Platform for in vitro assessment of endocrine disruption

Autoren: Daniel J. Carvalho, Anna M. Kip, Mírian Romitti, Marta Nazzari, Andreas Tegel, Matthias Stich, Christian Krause, Florian Caiment, Sabine Costagliola, Lorenzo Moroni, Stefan Giselbrecht
Veröffentlicht in: Advances Healthcare Materials, Ausgabe 12.8, March 2023, 2023, ISSN 1521-4095
Herausgeber: Wiley
DOI: 10.1002/adhm.202201555

Woven bone formation and mineralization by rat mesenchymal stromal cells imply increased expression of the intermediate filament desmin

Autoren: Giusy Di Conza, Fulvio Barbaro, Nicoletta Zini, Giulia Spaletta, Giulia Remaggi, Lisa Elviri, Salvatore Mosca, Silvio Caravelli, Massimiliano Mosca, Roberto Toni
Veröffentlicht in: Frontiers in Endocrinology, Ausgabe 14, 2023, Seite(n) 1-19, ISSN 1664-2392
Herausgeber: Frontiers Endocrinology
DOI: 10.3389/fendo.2023.1234569

Investigation of the effects of phthalates on in vitro thyroid models with RNA-Seq and ATAC-Seq

Autoren: Marta Nazzari, Mírian Romitti, Duncan Hauser, Daniel J. Carvalho, Stefan Giselbrecht, Lorenzo Moroni, Sabine Costagliola, Florian Caiment
Veröffentlicht in: Frontiers in Endocrinology, Ausgabe 14, 2023, 2023, ISSN 1664-2392
Herausgeber: Frontiers Media S.A
DOI: 10.3389/fendo.2023.1200211

Impact of benzo[a]pyrene, PCB153 and sex hormones on human ESC-Derived thyroid follicles using single cell transcriptomics

Autoren: Marta Nazzari, Mírian Romitti, Anna M. Kip, Rick Kamps, Sabine Costagliola, Twan van de Beucken, Lorenzo Moroni, Florian Caiment
Veröffentlicht in: Environment International, Ausgabe 188, 2024, Seite(n) 108748, ISSN 0160-4120
Herausgeber: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2024.108748

Generation of human thyroid organoids from embryonic stem cells to rescue hypothyroidism

Autoren: Mírian Romitti, Adrien Tourneur, Barbara de Faria da Fonseca, Gilles Doumont, Pierre Gillotay, Xiao-Hui Liao, Sema Elif Eski, Gaetan Van Simaeys, Laura Chomette, Helene Lasolle, Olivier Monestier, Dominika Figini Kasprzyk, Vincent Detours, Sumeet Pal Singh, Serge Goldman, Samuel Refetoff & Sabine Costagliola
Veröffentlicht in: European Thyroid Association Congress - Endocrine Abstracts, Ausgabe 1, 2022
Herausgeber: bioscientifica

Clamping strategies for organ-on-a-chip devices

Autoren: Daniel J. Carvalho, Lorenzo Moroni, Stefan Giselbrecht
Veröffentlicht in: Nature Reviews Materials, Ausgabe 19, January 2023, 2023, ISSN 1476-4687
Herausgeber: Nature
DOI: 10.1038/s41578-022-00523-z

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