A multistage model of thyroid gland function for screening endocrine-disrupting chemicals in a biologically sex-specific manner

Informations projet

SCREENED

N° de convention de subvention: 825745

DOI

10.3030/825745

Projet clôturé

Date de signature de la CE 26 Novembre 2018

Date de début 1 Janvier 2019

Date de fin 30 Juin 2024

Financé au titre de

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coût total

€ 5 655 088,75

Contribution de l’UE

€ 5 655 088,75

Coordonné par

UNIVERSITEIT MAASTRICHT
Netherlands

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (3)

Transcriptomic datasets of effect of EDs on thyroid cells

This deliverable consists of a report describing the transcriptomic data obtained in the 3D in vitro models.

3-5 AOPs for ED-mediated disruption of thyroid function completed in AOP Wiki

This deliverable consists of the submission on the OECD Environmental Health and Safety AOP Wiki of up to 3 AOPs describing the effects of ED’s on thyroid function in mammals in vivo.

Proteomic and datasets of effect of EDs on thyroid cells

This deliverable consists of a report describing the proteomics data obtained in the 3D in vitro models.

Websites, patent fillings, videos etc. (2)

Individualised press release for every partner

Edition of one press release to communicate about the project objectives, approach and results. The press release will be translated into the language of each partner country.

Launch of public website & Twitter account

SCREENED website with project information, news and results allowing interactions with third parties.

Publications

Thesis and dissertations (3)

Liquid chromatography – mass spectrometry, biomaterials and 3D printing in analytical applications

Auteurs: Giulia Remaggi
Publié dans: PhD Thesis, 2023
Éditeur: University of Parma, Italy

"A bioinformatic evaluation of endocrine disruptor – dependent proteomic profile of rat thyroid cells tested with an EU Joint Research Centre-submitted in vitro assay: Horizon Project SCREENED #825745"

Auteurs: Francesca Pia Quartulli
Publié dans: 2024, Page(s) 1-96
Éditeur: University of Parma, Parma, Italy URL https://www.unipr.it/

"An innovative European Joint Research Center-submitted in vitro assay for screening Endocrine Disruptors effects on thyroid cell function: Horizon Project SCREENED #825745"

Auteurs: Elena Caddeo
Publié dans: PhD Thesis, 2023
Éditeur: University of Parma, Italy

Peer reviewed articles (14)

Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism

Auteurs: Mírian Romitti, Adrien Tourneur, Barbara de Faria da Fonseca, Gilles Doumont, Pierre Gillotay, Xiao-Hui Liao, Sema Elif Eski, Gaetan Van Simaeys, Laura Chomette, Helene Lasolle, Olivier Monestier, Dominika Figini Kasprzyk, Vincent Detours, Sumeet Pal Singh, Serge Goldman, Samuel Refetoff & Sabine Costagliola
Publié dans: Nature Communications, Numéro November, 2022, 2022, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-022-34776-7

A Modular Microfluidic Organoid Platform Using LEGO‐Like Bricks

Auteurs: Daniel J. Carvalho, Anna M. Kip, Andreas Tegel, Matthias Stich, Christian Krause, Mírian Romitti, Carlotta Branca, Bart Verhoeven, Sabine Costagliola, Lorenzo Moroni, Stefan Giselbrecht
Publié dans: Advanced Healthcare Materials, Numéro 13, 2024, Page(s) 303444, ISSN 2192-2640
Éditeur: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202303444

Single-Cell Trajectory Inference Guided Enhancement of Thyroid Maturation In Vitro Using TGF-Beta Inhibition

Auteurs: Mírian Romitti, Sema Elif Eski, Barbara Faria Fonseca, Pierre Gillotay, Sumeet Pal Singh, Sabine Costagliola
Publié dans: Frontiers in Endocrinology, Numéro 12, 2021, ISSN 1664-2392
Éditeur: Frontiers
DOI: 10.3389/fendo.2021.657195

CODA: a combo-Seq data analysis workflow

Auteurs: Marta Nazzari, Duncan Hauser, Marcel van Herwijnen, Mírian Romitti, Daniel J Carvalho, Anna M Kip, and Florian Caiment
Publié dans: Briefings in Bioinformatics, Numéro 24, January 2023, 2023, Page(s) 1, ISSN 1477-4054
Éditeur: Oxford University Press
DOI: 10.1093/bib/bbac582

Microtopography of Immune Cells in Osteoporosis and Bone Lesions by Endocrine Disruptors

Auteurs: Roberto Toni, Giusy Di Conza, Fulvio Barbaro, Nicoletta Zini, Elia Consolini, Davide Dallatana, Manuela Antoniel, Enrico Quarantini, Marco Quarantini, Sara Maioli, Celeste Angela Bruni, Lisa Elviri, Silvia Panseri, Simone Sprio, Monica Sandri, Anna Tampieri
Publié dans: Frontiers in Immunology, Numéro 11, 2020, ISSN 1664-3224
Éditeur: Frontiers
DOI: 10.3389/fimmu.2020.01737

A Computational Template for Three-Dimensional Modeling of the Vascular Scaffold of the Human Thyroid Gland

Auteurs: Giulia Spaletta; Mark Sofroniou; Fulvio Barbaro; Giusy di Conza; Salvatore Mosca; Roberto Toni
Publié dans: Tissue Engineering Part A, Numéro Volume 29, Numbers 1 and 2, 2023, 2023, Page(s) 47-57, ISSN 1937-335X
Éditeur: Mary Ann Liebert, Inc.
DOI: 10.1089/ten.tea.2022.0148

Progress Toward and Challenges Remaining for Thyroid Tissue Regeneration

Auteurs: Mírian Romitti, Sabine Costagliola
Publié dans: Endocrinology, Numéro 164, 2023, Page(s) 164(10):bqad136, ISSN 1945-7170
Éditeur: Endocrine Society
DOI: 10.1210/endocr/bqad136

SCREENED: A Multistage Model of Thyroid Gland Function for Screening Endocrine-Disrupting Chemicals in a Biologically Sex-Specific Manner

Auteurs: Lorenzo Moroni, Fulvio Barbaro, Florian Caiment, Orla Coleman, Sabine Costagliola, Giusy Di Conza, Lisa Elviri, Stefan Giselbrecht, Christian Krause, Carlos Mota, Marta Nazzari, Stephen R. Pennington, Annette Ringwald, Monica Sandri, Simon Thomas, James Waddington, Roberto Toni
Publié dans: International Journal of Molecular Sciences, Numéro 21/10, 2020, Page(s) 3648, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21103648

A targeted mass spectrometry method to screen collagen types I-V in the decellularized 3D extracellular matrix of the adult male rat thyroid

Auteurs: Marco Alfieri, Fulvio Barbaro, Elia Consolini, Elena Bassi, Davide Dallatana, Carlo Bergonzi, Annalisa Bianchera, Ruggero Bettini, Roberto Toni, Lisa Elviri
Publié dans: Talanta, Numéro 193, 2019, Page(s) 1-8, ISSN 0039-9140
Éditeur: Elsevier BV
DOI: 10.1016/j.talanta.2018.09.087

Decellularization detergents as methdological variables in mass spectrometry of stromal matrices

Auteurs: Giulia Remaggi, Fulvio Barbaro, Giusy Di Conza, Giovanna Trevisi, Carlo Bergonzi
Publié dans: Tissue Egineering Part C Methods, Numéro Volume 28, Number 4, 2022, 2022, Page(s) 148 - 157, ISSN 1937-3384
Éditeur: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tec.2021.0191

Thyroid-on-a-chip: An organoid Platform for in vitro assessment of endocrine disruption

Auteurs: Daniel J. Carvalho, Anna M. Kip, Mírian Romitti, Marta Nazzari, Andreas Tegel, Matthias Stich, Christian Krause, Florian Caiment, Sabine Costagliola, Lorenzo Moroni, Stefan Giselbrecht
Publié dans: Advances Healthcare Materials, Numéro 12.8, March 2023, 2023, ISSN 1521-4095
Éditeur: Wiley
DOI: 10.1002/adhm.202201555

Woven bone formation and mineralization by rat mesenchymal stromal cells imply increased expression of the intermediate filament desmin

Auteurs: Giusy Di Conza, Fulvio Barbaro, Nicoletta Zini, Giulia Spaletta, Giulia Remaggi, Lisa Elviri, Salvatore Mosca, Silvio Caravelli, Massimiliano Mosca, Roberto Toni
Publié dans: Frontiers in Endocrinology, Numéro 14, 2023, Page(s) 1-19, ISSN 1664-2392
Éditeur: Frontiers Endocrinology
DOI: 10.3389/fendo.2023.1234569

Investigation of the effects of phthalates on in vitro thyroid models with RNA-Seq and ATAC-Seq

Auteurs: Marta Nazzari, Mírian Romitti, Duncan Hauser, Daniel J. Carvalho, Stefan Giselbrecht, Lorenzo Moroni, Sabine Costagliola, Florian Caiment
Publié dans: Frontiers in Endocrinology, Numéro 14, 2023, 2023, ISSN 1664-2392
Éditeur: Frontiers Media S.A
DOI: 10.3389/fendo.2023.1200211

Impact of benzo[a]pyrene, PCB153 and sex hormones on human ESC-Derived thyroid follicles using single cell transcriptomics

Auteurs: Marta Nazzari, Mírian Romitti, Anna M. Kip, Rick Kamps, Sabine Costagliola, Twan van de Beucken, Lorenzo Moroni, Florian Caiment
Publié dans: Environment International, Numéro 188, 2024, Page(s) 108748, ISSN 0160-4120
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2024.108748

Conference proceedings (1)

Generation of human thyroid organoids from embryonic stem cells to rescue hypothyroidism

Auteurs: Mírian Romitti, Adrien Tourneur, Barbara de Faria da Fonseca, Gilles Doumont, Pierre Gillotay, Xiao-Hui Liao, Sema Elif Eski, Gaetan Van Simaeys, Laura Chomette, Helene Lasolle, Olivier Monestier, Dominika Figini Kasprzyk, Vincent Detours, Sumeet Pal Singh, Serge Goldman, Samuel Refetoff & Sabine Costagliola
Publié dans: European Thyroid Association Congress - Endocrine Abstracts, Numéro 1, 2022
Éditeur: bioscientifica

Non-peer reviewed articles (1)

Clamping strategies for organ-on-a-chip devices

Auteurs: Daniel J. Carvalho, Lorenzo Moroni, Stefan Giselbrecht
Publié dans: Nature Reviews Materials, Numéro 19, January 2023, 2023, ISSN 1476-4687
Éditeur: Nature
DOI: 10.1038/s41578-022-00523-z