A multistage model of thyroid gland function for screening endocrine-disrupting chemicals in a biologically sex-specific manner

Livrables

Transcriptomic datasets of effect of EDs on thyroid cells

This deliverable consists of a report describing the transcriptomic data obtained in the 3D in vitro models.

Proteomic and datasets of effect of EDs on thyroid cells

This deliverable consists of a report describing the proteomics data obtained in the 3D in vitro models.

Individualised press release for every partner

Edition of one press release to communicate about the project objectives, approach and results. The press release will be translated into the language of each partner country.

Launch of public website & Twitter account

SCREENED website with project information, news and results allowing interactions with third parties.

Publications

Liquid chromatography – mass spectrometry, biomaterials and 3D printing in analytical applications

Auteurs: Giulia Remaggi
Publié dans: PhD Thesis, 2023
Éditeur: University of Parma, Italy

"An innovative European Joint Research Center-submitted in vitro assay for screening Endocrine Disruptors effects on thyroid cell function: Horizon Project SCREENED #825745"

Auteurs: Elena Caddeo
Publié dans: PhD Thesis, 2023
Éditeur: University of Parma, Italy

Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism

Auteurs: Mírian Romitti, Adrien Tourneur, Barbara de Faria da Fonseca, Gilles Doumont, Pierre Gillotay, Xiao-Hui Liao, Sema Elif Eski, Gaetan Van Simaeys, Laura Chomette, Helene Lasolle, Olivier Monestier, Dominika Figini Kasprzyk, Vincent Detours, Sumeet Pal Singh, Serge Goldman, Samuel Refetoff & Sabine Costagliola
Publié dans: Nature Communications, Numéro November, 2022, 2022, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-022-34776-7

CODA: a combo-Seq data analysis workflow

Auteurs: Marta Nazzari, Duncan Hauser, Marcel van Herwijnen, Mírian Romitti, Daniel J Carvalho, Anna M Kip, and Florian Caiment
Publié dans: Briefings in Bioinformatics, Numéro 24, January 2023, 2023, Page(s) 1, ISSN 1477-4054
Éditeur: Oxford University Press
DOI: 10.1093/bib/bbac582

A Computational Template for Three-Dimensional Modeling of the Vascular Scaffold of the Human Thyroid Gland

Auteurs: Giulia Spaletta; Mark Sofroniou; Fulvio Barbaro; Giusy di Conza; Salvatore Mosca; Roberto Toni
Publié dans: Tissue Engineering Part A, Numéro Volume 29, Numbers 1 and 2, 2023, 2023, Page(s) 47-57, ISSN 1937-335X
Éditeur: Mary Ann Liebert, Inc.
DOI: 10.1089/ten.tea.2022.0148

SCREENED: A Multistage Model of Thyroid Gland Function for Screening Endocrine-Disrupting Chemicals in a Biologically Sex-Specific Manner

Auteurs: Lorenzo Moroni, Fulvio Barbaro, Florian Caiment, Orla Coleman, Sabine Costagliola, Giusy Di Conza, Lisa Elviri, Stefan Giselbrecht, Christian Krause, Carlos Mota, Marta Nazzari, Stephen R. Pennington, Annette Ringwald, Monica Sandri, Simon Thomas, James Waddington, Roberto Toni
Publié dans: International Journal of Molecular Sciences, Numéro 21/10, 2020, Page(s) 3648, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21103648

A targeted mass spectrometry method to screen collagen types I-V in the decellularized 3D extracellular matrix of the adult male rat thyroid

Auteurs: Marco Alfieri, Fulvio Barbaro, Elia Consolini, Elena Bassi, Davide Dallatana, Carlo Bergonzi, Annalisa Bianchera, Ruggero Bettini, Roberto Toni, Lisa Elviri
Publié dans: Talanta, Numéro 193, 2019, Page(s) 1-8, ISSN 0039-9140
Éditeur: Elsevier BV
DOI: 10.1016/j.talanta.2018.09.087

Decellularization detergents as methdological variables in mass spectrometry of stromal matrices

Auteurs: Giulia Remaggi, Fulvio Barbaro, Giusy Di Conza, Giovanna Trevisi, Carlo Bergonzi
Publié dans: Tissue Egineering Part C Methods, Numéro Volume 28, Number 4, 2022, 2022, Page(s) 148 - 157, ISSN 1937-3384
Éditeur: Mary Ann Liebert Inc.
DOI: 10.1089/ten.tec.2021.0191

Thyroid-on-a-chip: An organoid Platform for in vitro assessment of endocrine disruption

Auteurs: Daniel J. Carvalho, Anna M. Kip, Mírian Romitti, Marta Nazzari, Andreas Tegel, Matthias Stich, Christian Krause, Florian Caiment, Sabine Costagliola, Lorenzo Moroni, Stefan Giselbrecht
Publié dans: Advances Healthcare Materials, Numéro 12.8, March 2023, 2023, ISSN 1521-4095
Éditeur: Wiley
DOI: 10.1002/adhm.202201555

Investigation of the effects of phthalates on in vitro thyroid models with RNA-Seq and ATAC-Seq

Auteurs: Marta Nazzari, Mírian Romitti, Duncan Hauser, Daniel J. Carvalho, Stefan Giselbrecht, Lorenzo Moroni, Sabine Costagliola, Florian Caiment
Publié dans: Frontiers in Endocrinology, Numéro 14, 2023, 2023, ISSN 1664-2392
Éditeur: Frontiers Media S.A
DOI: 10.3389/fendo.2023.1200211

Clamping strategies for organ-on-a-chip devices

Auteurs: Daniel J. Carvalho, Lorenzo Moroni, Stefan Giselbrecht
Publié dans: Nature Reviews Materials, Numéro 19, January 2023, 2023, ISSN 1476-4687
Éditeur: Nature
DOI: 10.1038/s41578-022-00523-z

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