Breaking borders, Functional genetic screens of structural regulatory DNA elements

Project Information

Breakborder

Grant agreement ID: 832844

DOI

10.3030/832844

Project closed

EC signature date 23 May 2019

Start date 1 September 2019

End date 31 August 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 497 000,00

EU contribution

€ 2 497 000,00

Coordinated by

STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (11)

A comprehensive enhancer screen identifies TRAM2 as a key and novel mediator of YAP oncogenesis

Author(s): Li Li, Alejandro P. Ugalde, Colinda L. G. J. Scheele, Sebastian M. Dieter, Remco Nagel, Jin Ma, Abhijeet Pataskar, Gozde Korkmaz, Ran Elkon, Miao-Ping Chien, Li You, Pin-Rui Su, Onno B. Bleijerveld, Maarten Altelaar, Lyubomir Momchev, Zohar Manber, Ruiqi Han, Pieter C. van Breugel, Rui Lopes, Peter ten Dijke, Jacco van Rheenen, Reuven Agami
Published in: Genome Biology, Issue 22/1, 2021, ISSN 1474-760X
Publisher: BioMed Central
DOI: 10.1186/s13059-021-02272-8

A CRISPR-Cas9 screen identifies essential CTCF anchor sites for estrogen receptor-driven breast cancer cell proliferation

Author(s): Gozde Korkmaz, Zohar Manber, Rui Lopes, Stefan Prekovic, Karianne Schuurman, Yongsoo Kim, Hans Teunissen, Koen Flach, Elzo de Wit, Giorgio G Galli, Wilbert Zwart, Ran Elkon, Reuven Agami
Published in: Nucleic Acids Research, Issue 47/18, 2019, Page(s) 9557-9572, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkz675

DNA damage induces p53-independent apoptosis through ribosome stalling

Author(s): Nicolaas J. Boon, Rafaela A. Oliveira, Pierré-René Körner, Adva Kochavi, Sander Mertens, Yuval Malka, Rhianne Voogd, Suzanne E. M. van der Horst, Maarten A. Huismans, Lidwien P. Smabers, Jonne M. Draper, Lodewyk F. A. Wessels, Peter Haahr, Jeanine M. L. Roodhart, Ton N. M. Schumacher, Hugo J. Snippert, Reuven Agami, Thijn R. Brummelkamp
Published in: Science, Issue 384, 2024, Page(s) 785-792, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.adh7950

Molecular mechanisms of non-genetic aberrant peptide production in cancer

Author(s): Demi Wernaart, Amos Fumagalli, Reuven Agami
Published in: Oncogene, Issue 43, 2024, Page(s) 2053-2062, ISSN 0950-9232
Publisher: Nature Publishing Group
DOI: 10.1038/s41388-024-03069-2

Arginine deprivation enriches lung cancer proteomes with cysteine by inducing arginine-to-cysteine substitutants

Author(s): Chao Yang, Abhijeet Pataskar, Xiaodong Feng, Jasmine Montenegro Navarro, Inés Paniagua, Jacqueline J.L. Jacobs, Esther A. Zaal, Celia R. Berkers, Onno B. Bleijerveld, Reuven Agami
Published in: Molecular Cell, Issue 84, 2024, Page(s) 1904-1916.e7, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2024.04.012

Tryptophan depletion results in tryptophan-to-phenylalanine substitutants

Author(s): Abhijeet Pataskar, Julien Champagne, Remco Nagel, Juliana Kenski, Maarja Laos, Justine Michaux, Hui Song Pak, Onno B. Bleijerveld, Kelly Mordente, Jasmine Montenegro Navarro, Naomi Blommaert, Morten M. Nielsen, Domenica Lovecchio, Everett Stone, George Georgiou, Mark C. de Gooijer, Olaf van Tellingen, Maarten Altelaar, Robbie P. Joosten, Anastassis Perrakis, Johanna Olweus, Michal Bassani-Sternber
Published in: Nature, 2022, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-04499-2

Oncogene-dependent sloppiness in mRNA translation

Author(s): Julien Champagne, Abhijeet Pataskar, Naomi Blommaert, Remco Nagel, Demi Wernaart, Sofia Ramalho, Juliana Kenski, Onno B Bleijerveld, Esther A Zaal, Celia R Berkers, Maarten Altelaar, Daniel S Peeper, William J Faller, Reuven Agami
Published in: Molecular Cell, 2021, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2021.09.002

Alternative cleavage and polyadenylation generates downstream uncapped RNA isoforms with translation potential

Author(s): Yuval Malka, Ferhat Alkan, Shinyeong Ju, Pierre-Rene Körner, Abhijeet Pataskar, Eldad Shulman, Fabricio Loayza-Puch, Julien Champagne, Casper Wenzel, William James Faller, Ran Elkon, Cheolju Lee, Reuven Agami
Published in: Molecular Cell, Issue 82, 2024, Page(s) 3840-3855.e8, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2022.09.036

Boosting Antitumor Immunity with an Expanded Neoepitope Landscape

Author(s): Remco Nagel, Abhijeet Pataskar, Julien Champagne, Reuven Agami
Published in: Cancer Research, Issue 82, 2023, Page(s) 3637-3649, ISSN 0008-5472
Publisher: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-22-1525

Proteome diversification by mRNA translation in cancer

Author(s): Adva Kochavi, Domenica Lovecchio, William James Faller, Reuven Agami
Published in: Molecular Cell, Issue 83, 2024, Page(s) 469-480, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2022.11.014

Anti-tumour immunity induces aberrant peptide presentation in melanoma

Author(s): Osnat Bartok, Abhijeet Pataskar, Remco Nagel, Maarja Laos, Eden Goldfarb, Deborah Hayoun, Ronen Levy, Pierre-Rene Körner, Inger Z. M. Kreuger, Julien Champagne, Esther A. Zaal, Onno B. Bleijerveld, Xinyao Huang, Juliana Kenski, Jennifer Wargo, Alexander Brandis, Yishai Levin, Orel Mizrahi, Michal Alon, Sacha Lebon, Weiwen Yang, Morten M. Nielsen, Noam Stern-Ginossar, Maarten Altelaar, Celia R. Be
Published in: Nature, Issue 590/7845, 2021, Page(s) 332-337, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-03054-1

Non-peer reviewed articles (1)

Two-layer design protects genes from mutations in their enhancers

Author(s): Ran Elkon, Reuven Agami
Published in: Nature, Issue 609, 2022, Page(s) 477-478, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/d41586-022-02341-3