Descrizione del progetto
Gli impianti in seta: una prospettiva per milioni di persone
I bachi da seta producono un materiale fibroso per formare i loro bozzoli. Le fibre sono state a lungo utilizzate per realizzare tessuti di seta per abbigliamento di alta gamma. Più recentemente, i polimeri proteici versatili nei bozzoli sono stati sfruttati per applicazioni biomediche. Oltre a biocompatibilità, elasticità e resistenza strutturale, la fibroina della seta offre trasparenza, permeabilità e un indice di rifrazione che la rendono particolarmente attraente per l’uso negli occhi. SILK-EYE sta aprendo la strada allo sviluppo della prossima generazione di impianti e lenti corneali che sfruttano queste caratteristiche. Il team prevede di offrire soluzioni più efficaci, sicure e convenienti per trattare la crescente incidenza di malattie e condizioni che colpiscono la vista a livello globale. Preparati per il tuo prossimo abbinamento in seta: sciarpa e lente accomodativa.
Obiettivo
Prevalent eye diseases, such as myopia, presbyopia, and corneal disease affect millions worldwide, but for now cannot be prevented. Surgical interventions of these conditions are turning to additive surgery, exemplified by corneal implants or the replacement of the natural crystalline lens by (or addition of) an intraocular lens, as it reduces complications of tissue removal surgeries.
Current eye treatments involving adding tissue or lenses exist in the form of amnion bandages, corneal inlays, and intraocular lenses. However, those approaches suffer from a number of shortcomings: corneal haze or rejection; risk of disease transmission, short lifespan, need of cryopreservation and donor tissue; lack of compliance of lens designs and biomaterials. In particular, no material has been found that fully meets the requirements for mechanical properties, transparency, biocompatibility and versatility for applications in the cornea and in accommodating intraocular lenses.
In recent years, silk fibroin derived from silkworm cocoons has emerged as a protein polymer for biomaterial applications. SILK-EYE will develop a new generation of corneal and intraocular implants, using silk-based materials tuned to each specific application and light enabling procedure. The silk-based implants will feature both the accessibility advantages of synthetic materials and the structural and biocompatibility properties of allografts, capitalizing on silk’s unique potential for transparency, controllable stiffness and degradability, refractive index and permeability, and their potential for light-induced cross-linking and bonding in the eye. SILK-EYE will design radically novel corneal dressings and implants, and accommodating intraocular lenses that are more biocompatible and functional than current synthetic implants, and are safer, more tunable, accessible and affordable than donor allografts, potentially revolutionizing how the major corrective procedures in ophthalmology are performed.
Campo scientifico
Parole chiave
Programma(i)
Argomento(i)
Meccanismo di finanziamento
ERC-ADG - Advanced GrantIstituzione ospitante
28006 Madrid
Spagna