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Biological relevance of the multiple infection unit as a novel target for antiviral development

Project description

Investigating the role of viral 'hubs' in the spread of enteric infections

Recent studies of infection in vivo and in vitro suggest that enteric viruses travel in groups, in inverted phosphatidylserine vesicles or at the surface of commensal bacteria. These multiple infection units (MIU) might increase the viral multiplicity of infection. The hypothesis of the EU-funded CM_GF project is that targeting MIU will inhibit enteric virus infection. The human norovirus (HNoV) is employed as a model to test the hypothesis that MIU promote HNoV infection. Researchers will develop an in vitro screening platform for small molecule inhibitors of the infection and identify bacterial species bound to HNoV in patients. Finally, they will test the efficacy of the identified inhibitors in the ex vivo and in vivo models.

Coordinator

UNIVERSITAET zu LUEBECK
Net EU contribution
€ 226 010,88
Address
Ratzeburger Allee 160
23562 Lubeck
Germany

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Partners (1)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

UNIVERSITY OF MICHIGAN THE REGENTS OF THE UNIVERSITY OF MICHIGAN
United States
Net EU contribution
€ 0,00
Address
South Street 3003 1068
46109 1274 Ann Arbor

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 144 607,68