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Light-REsponsive Nanomachines for Targeted Eradication of BactErial Pathogens in LocaLised InfectIONs

Description du projet

Nanomachines: les nouveaux agents antimicrobiens

La résistance aux antimicrobiens est un problème majeur de santé dans le monde, c’est pourquoi de nouveaux antibiotiques s’avèrent nécessaires. Les nanomachines moléculaires sont des molécules organiques synthétiques capables de pénétrer des bicouches lipidiques par le biais d’un mouvement de rotation, et elles sont apparues comme une alternative intéressante aux antimicrobiens. Le projet REBELLION, financé par l’UE, propose de synthétiser et de sélectionner des nanomachines moléculaires qui répondent à la lumière. Les scientifiques évalueront les molécules candidates en fonction de leur efficacité par rapport à un éventail de cibles microbiennes et de leur sécurité dans des cellules de mammifères. Outre une sélectivité accrue, ces antimicrobiens innovants ont démontré une réduction du potentiel de développement de la résistance aux antimicrobiens.

Objectif

Antimicrobial resistance (AMR) has been identified as a major threat to mankind in the 21st century. Thus, there is a critical need to develop new antimicrobials and new delivery strategies to preserve the viability of the existing antibiotics. One such strategy is the use of molecular nanomachines (MNMs) for targeted and controlled inactivation of bacterial pathogens.
REBELLION aims to develop new light responsive MNMs against bacterial pathogens with minimal damage to mammalian tissues. This strategy will provide a therapeutic advantage in terms of efficacy and selectivity compared with current therapeutics while minimizing the potential for the development of AMR.
The proposed research programme combines (1) chemical synthesis of new MNMs, (2) assessment of their efficacy against clinically relevant bacterial pathogens, (3) evaluation of their safety to mammalian cells and (4) in vivo efficacy testing. The results obtained have the potential to lead to an alternative, entirely novel class of antimicrobials (MNMs) and to become a stepping stone towards future clinical trials.
REBELLION is a vital, multidisciplinary and international endeavor that will bring together this fellow’s core expertise in microbial photobiology with (1) antibiotic resistance and infection at IdISBa (beneficiary, Spain), (2) state-of-the-art technology in light-driven antimicrobial therapy, and experience in in vitro and in vivo drug efficacy testing championed by GAMA Therapeutics (host, USA) and (3) expert knowledge in nanomachine synthesis by the Nanotechnology Department of Rice University (co-host, USA).
I will be trained by top-level scientists and widen my network and competencies through advanced training in nanotechnology, infection, and drug development and testing. This action will catalyze my career into an independent and mature researcher with an eclectic skill set geared toward producing a unique contribution to European excellence in antimicrobial discovery technology.

Coordinateur

FUNDACIO INSTITUT D'INVESTIGACIO SANITARIA ILLES BALEARS
Contribution nette de l'UE
€ 245 732,16
Adresse
CARRETERA DE VALLDEMOSSA, 79
07120 Palma
Espagne

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Région
Este Illes Balears Mallorca
Type d’activité
Research Organisations
Liens
Coût total
€ 245 732,16

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