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Light-REsponsive Nanomachines for Targeted Eradication of BactErial Pathogens in LocaLised InfectIONs

Descripción del proyecto

Nanomáquinas como nuevos agentes antimicrobianos

La resistencia a los antimicrobianos (RAM) constituye uno de los principales problemas sanitarios en todo el mundo, lo que requiere el desarrollo de nuevos antibióticos. Las nanomáquinas moleculares son moléculas orgánicas sintéticas que pueden atravesar las bicapas lipídicas mediante un movimiento de rotación, y se han posicionado como alternativas antimicrobianas prometedoras. El proyecto financiado con fondos europeos REBELLION tiene por objeto sintetizar y analizar nanomáquinas moleculares fotosensibles. Sus científicos evaluarán las moléculas de interés por su eficacia contra una variedad de dianas microbianas y su seguridad en células de mamíferos. Estos compuestos antimicrobianos innovadores no solo tienen una mayor selectividad, sino que además demuestran un menor potencial para el desarrollo de RAM.

Objetivo

Antimicrobial resistance (AMR) has been identified as a major threat to mankind in the 21st century. Thus, there is a critical need to develop new antimicrobials and new delivery strategies to preserve the viability of the existing antibiotics. One such strategy is the use of molecular nanomachines (MNMs) for targeted and controlled inactivation of bacterial pathogens.
REBELLION aims to develop new light responsive MNMs against bacterial pathogens with minimal damage to mammalian tissues. This strategy will provide a therapeutic advantage in terms of efficacy and selectivity compared with current therapeutics while minimizing the potential for the development of AMR.
The proposed research programme combines (1) chemical synthesis of new MNMs, (2) assessment of their efficacy against clinically relevant bacterial pathogens, (3) evaluation of their safety to mammalian cells and (4) in vivo efficacy testing. The results obtained have the potential to lead to an alternative, entirely novel class of antimicrobials (MNMs) and to become a stepping stone towards future clinical trials.
REBELLION is a vital, multidisciplinary and international endeavor that will bring together this fellow’s core expertise in microbial photobiology with (1) antibiotic resistance and infection at IdISBa (beneficiary, Spain), (2) state-of-the-art technology in light-driven antimicrobial therapy, and experience in in vitro and in vivo drug efficacy testing championed by GAMA Therapeutics (host, USA) and (3) expert knowledge in nanomachine synthesis by the Nanotechnology Department of Rice University (co-host, USA).
I will be trained by top-level scientists and widen my network and competencies through advanced training in nanotechnology, infection, and drug development and testing. This action will catalyze my career into an independent and mature researcher with an eclectic skill set geared toward producing a unique contribution to European excellence in antimicrobial discovery technology.

Coordinador

FUNDACIO INSTITUT D'INVESTIGACIO SANITARIA ILLES BALEARS
Aportación neta de la UEn
€ 245 732,16
Dirección
CARRETERA DE VALLDEMOSSA, 79
07120 Palma
España

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Región
Este Illes Balears Mallorca
Tipo de actividad
Research Organisations
Enlaces
Coste total
€ 245 732,16

Socios (1)