A DNA NANOtechology toolkit for artificial CELL design

Project Information

NANOCELL

Grant agreement ID: 851667

DOI

10.3030/851667

Project closed

EC signature date 4 October 2019

Start date 1 January 2020

End date 30 September 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 497 477,00

EU contribution

€ 1 497 477,00

Coordinated by

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (22)

Amphiphilic DNA nanostructures for bottom-up synthetic biology.

Author(s): Roger Rubio-Sánchez; Roger Rubio-Sánchez; Giacomo Fabrini; Pietro Cicuta; Lorenzo Di Michele; Lorenzo Di Michele
Published in: ChemComm, 2021, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1cc04311k

Cation-responsive and photocleavable hydrogels from non-canonical amphiphilic DNA nanostructures

Author(s): Giacomo Fabrini; Aisling Minard; Ryan A. Brady; Marco Di Antonio; Lorenzo Di Michele
Published in: Nano Letters, 2022, ISSN 1530-6984
Publisher: American Chemical Society
DOI: 10.1021/acs.nanolett.1c03314

Detecting Nanoscale Distribution of Protein Pairs by Proximity-Dependent Super-resolution Microscopy.

Author(s): Alexander H. Clowsley; William T. Kaufhold; Tobias Lutz; Anna Meletiou; Lorenzo Di Michele; Christian Soeller
Published in: Journal of the American Chemical Society, 2020, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1101/591081

Interplay of the mechanical and structural properties of DNA nanostructures determines their electrostatic interactions with lipid membranes

Author(s): Diana Morzy; Cem Tekin; Vincenzo Caroprese; Roger Rubio-Sánchez; Lorenzo Di Michele; Maartje M. C. Bastings
Published in: Nanoscale, 2023, ISSN 2040-3372
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2nr05368c

Thermally Driven Membrane Phase Transitions Enable Content Reshuffling in Primitive Cells.

Author(s): Roger Rubio-Sánchez; Derek K. O’Flaherty; Anna Wang; Francesca Coscia; Gianluca Petris; Lorenzo Di Michele; Lorenzo Di Michele; Pietro Cicuta; Claudia Bonfio; Claudia Bonfio
Published in: Journal of the American Chemical Society, Issue 5, 2021, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.1c06595

Cations Regulate Membrane Attachment and Functionality of DNA Nanostructures

Author(s): Diana Morzy, Roger Rubio-Sánchez, Himanshu Joshi, Aleksei Aksimentiev, Lorenzo Di Michele, Ulrich F. Keyser
Published in: Journal of the American Chemical Society, Issue 143/19, 2021, Page(s) 7358-7367, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.1c00166

The ALS/FTD-related C9orf72 hexanucleotide repeat expansion forms RNA condensates through multimolecular G-quadruplexes

Author(s): Federica Raguseo; Yiran Wang; Jessica Li; Marija Petrić Howe; Rubika Balendra; Anouk Huyghebaert; Devkee M. Vadukul; Diana A. Tanase; Thomas E. Maher; Layla Malouf; Roger Rubio-Sánchez; Francesco A. Aprile; Yuval Elani; Rickie Patani; Lorenzo Di Michele; Marco Di Antonio
Published in: Nature Communications, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-43872-1

Fast, multicolour optical sectioning over extended fields of view with patterned illumination and machine learning

Author(s): Ward, Edward N; McClelland, Rebecca M; Lamb, Jacob R; Rubio-Sánchez, Roger; Christensen, Charles N; Mazumder, Bismoy; Kapsiani, Sofia; Mascheroni, Luca; Di Michele, Lorenzo; Kaminski Schierle, Gabriele S; Kaminski, Clemens F
Published in: Biomedical Optics Express, Issue 3, 2024, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/boe.510912

Modulating membrane fusion through the design of fusogenic DNA circuits and bilayer composition

Author(s): Miguel Paez-Perez; I. Alasdair Russell; Pietro Cicuta; Lorenzo Di Michele
Published in: Soft Matter, 2022, ISSN 1744-683X
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2sm00863g

Probing the Mechanical Properties of DNA Nanostructures with Metadynamics

Author(s): Will T. Kaufhold, Wolfgang Pfeifer, Carlos E. Castro, and Lorenzo Di Michele
Published in: ACS Nano, 2022, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.1c08999

Sculpting DNA-based synthetic cells through phase separation and phase-targeted activity

Author(s): Layla Malouf; Diana A. Tanase; Giacomo Fabrini; Miguel Paez-Perez; Adrian Leathers; Michael J. Booth; Lorenzo Di Michele
Published in: Chem, 2023, ISSN 2451-9294
Publisher: Cell Press
DOI: 10.1016/j.chempr.2023.10.004

Adaptable DNA interactions regulate surface triggered self assembly

Author(s): Roberta Lanfranco, Pritam Kumar Jana, Gilles Bruylants, Pietro Cicuta, Bortolo Matteo Mognetti, Lorenzo Di Michele
Published in: Nanoscale, Issue 12/36, 2020, Page(s) 18616-18620, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0nr04461j

Reaction-diffusion patterning of DNA-based artificial cells

Author(s): Adrian Leathers; Michal Walczak; Ryan A. Brady; Assala Al Samad; Jurij Kotar; Michael J. Booth; Pietro Cicuta; Lorenzo Di Michele
Published in: Journal of the American Chemical Society, 2022, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.2c06140

DNA-Based Optical Quantification of Ion Transport across Giant Vesicles

Author(s): Marcus Fletcher; Jinbo Zhu; Roger Rubio-Sánchez; Sarah E Sandler; Kareem Al Nahas; Lorenzo Di Michele; Ulrich F Keyser; Ran Tivony
Published in: ACS Nano, 2023, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.2c07496

DNA-Origami Line-Actants Control Domain Organization and Fission in Synthetic Membranes

Author(s): Roger Rubio-Sánchez; Bortolo Matteo Mognetti; Pietro Cicuta; Lorenzo Di Michele
Published in: Journal of the American Chemical Society, 2022, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.3c01493

A Modular, Dynamic, DNA-Based Platform for Regulating Cargo Distribution and Transport between Lipid Domains

Author(s): Roger Rubio-Sánchez, Simone Eizagirre Barker, Michal Walczak, Pietro Cicuta, Lorenzo Di Michele
Published in: Nano Letters, Issue 21/7, 2021, Page(s) 2800-2808, ISSN 1530-6984
Publisher: American Chemical Society
DOI: 10.1021/acs.nanolett.0c04867

A Synthetic Signaling Network Imitating the Actionof Immune Cells in Response to Bacterial Metabolism

Author(s): Michal Walczak, Leonardo Mancini, Jiayi Xu, Federica Raguseo, Jurij Kotar, Pietro Cicuta,and Lorenzo Di Michele
Published in: Advanced Materials, 2023, ISSN 1521-4095
Publisher: Wiley
DOI: 10.1002/adma.202301562

Lipid vesicle-based molecular robots

Author(s): Zugui Peng; Shoji Iwabuchi; Kayano Izumi; Sotaro Takiguchi; Misa Yamaji; Shoko Fujita; Harune Suzuki; Fumika Kambara; Genki Fukasawa; Aileen Cooney; Lorenzo Di Michele; Yuval Elani; Tomoaki Matsuura; Ryuji Kawano
Published in: Lab on a Chip, 2024, ISSN 1473-0189
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3lc00860f

Influence of hydrophobic moieties on the crystallization of amphiphilic DNA nanostructures

Author(s): Jurij Kotar; Adrian Leathers; Michal Walczak; Ryan Brady; Lorenzo Di Michele
Published in: The Journal of Chemical Physics, 2023, ISSN 0021-9606
Publisher: American Institute of Physics
DOI: 10.1063/5.0132484

Repeat DNA-PAINT suppresses background and non-specific signals in optical nanoscopy

Author(s): Alexander H. Clowsley, William T. Kaufhold, Tobias Lutz, Anna Meletiou, Lorenzo Di Michele, Christian Soeller
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-20686-z

DNA-assisted selective electrofusion (DASE) of <i>Escherichia coli</i> and giant lipid vesicles

Author(s): Pietro Cicuta; Lorenzo Di Michele; Sho Takamori; Shoji Takeuchi
Published in: Nanoscale, 2022, ISSN 2040-3372
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2nr03105a

Responsive core-shell DNA particles trigger lipid-membrane disruption and bacteria entrapment

Author(s): Michal Walczak, Ryan A. Brady, Leonardo Mancini, Claudia Contini, Roger Rubio-Sánchez, William T. Kaufhold, Pietro Cicuta, Lorenzo Di Michele
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-24989-7