Bright, coherent and focused light to resolve neural circuits

Project Information

BRILLIANCE

Grant agreement ID: 852455

DOI

10.3030/852455

Project closed

EC signature date 28 February 2020

Start date 1 March 2020

End date 28 February 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 430 275,00

EU contribution

€ 1 430 275,00

Coordinated by

EUROPEAN SYNCHROTRON RADIATION FACILITY
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (1)

Data Management Plan

Open Research Data Pilot

Publications

Peer reviewed articles (10)

Dense neuronal reconstruction through X-ray holographic nano-tomography

Author(s): Aaron T. Kuan, Jasper S. Phelps, Logan A. Thomas, Tri M. Nguyen, Julie Han, Chiao-Lin Chen, Anthony W. Azevedo, John C. Tuthill, Jan Funke, Peter Cloetens, Alexandra Pacureanu, Wei-Chung Allen Lee
Published in: Nature Neuroscience, Issue 23/12, 2020, Page(s) 1637-1643, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-020-0704-9

Functional and multiscale 3D structural investigation of brain tissue through correlative in vivo physiology, synchrotron microtomography and volume electron microscopy

Author(s): Carles Bosch, Tobias Ackels, Alexandra Pacureanu, Yuxin Zhang, Christopher J. Peddie, Manuel Berning, Norman Rzepka, Marie-Christine Zdora, Isabell Whiteley, Malte Storm, Anne Bonnin, Christoph Rau, Troy Margrie, Lucy Collinson & Andreas T. Schaefer
Published in: Nature Communications, Issue 20411723, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-30199-6

Sample Preparation and Warping Accuracy for Correlative Multimodal Imaging in the Mouse Olfactory Bulb Using 2-Photon, Synchrotron X-Ray and Volume Electron Microscopy

Author(s): Yuxin Zhang, Tobias Ackels, Alexandra Pacureanu, Marie-Christine Zdora, Anne Bonnin, Andreas T Schaefer, Carles Bosch
Published in: Frontiers in Cell and Developmental Biology, Issue 2296634X, 2022, ISSN 2296-634X
Publisher: Frontiers
DOI: 10.3389/fcell.2022.880696

Biomechanical origins of proprioceptor feature selectivity and topographic maps in the Drosophila leg

Author(s): Akira Mamiya, Anne Sustar, Igor Siwanowicz, Yanyan Qi, Tzu-Chiao Lu, Pralaksha Gurung, Chenghao Chen, Jasper S. Phelps, Aaron T. Kuan, Alexandra Pacureanu, Wei-Chung Allen Lee, Hongjie Li, Natasha Mhatre, John C. Tuthill
Published in: Neuron, Issue 111, 2024, Page(s) 3230-3243.e14, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2023.07.009

Nondestructive X-ray tomography of brain tissue ultrastructure

Author(s): Carles Bosch, Tomas Aidukas, Mirko Holler, Alexandra Pacureanu, Elisabeth Müller, Christopher J. Peddie, Yuxin Zhang, Phil Cook, Lucy Collinson, Oliver Bunk, Andreas Menzel, Manuel Guizar-Sicairos, Gabriel Aeppli, Ana Diaz, Adrian A. Wanner, Andreas T. Schaefer
Published in: Nature Methods, Issue 22, 2025, Page(s) 2631-2638, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/s41592-025-02891-0

Connectomic reconstruction of a female Drosophila ventral nerve cord

Author(s): Anthony Azevedo, Ellen Lesser, Jasper S. Phelps, Brandon Mark, Leila Elabbady, Sumiya Kuroda, Anne Sustar, Anthony Moussa, Avinash Khandelwal, Chris J. Dallmann, Sweta Agrawal, Su-Yee J. Lee, Brandon Pratt, Andrew Cook, Kyobi Skutt-Kakaria, Stephan Gerhard, Ran Lu, Nico Kemnitz, Kisuk Lee, Akhilesh Halageri, Manuel Castro, Dodam Ih, Jay Gager, Marwan Tammam, Sven Dorkenwald, Forrest Collman, Casey
Published in: Nature, Issue 631, 2024, Page(s) 360-368, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-024-07389-x

Scaling up X-ray holographic nanotomography for neuronal tissue imaging

Author(s): Jayde Livingstone, Carles Bosch, Aaron T. Kuan, Lucas Benoït, Paolo Busca, Thierry Martin, Mohd F. E. B. Mazri, Wangchu Xiang, Wei-Chung Allen Lee, Andreas T. Schaefer, Peter Cloetens, Alexandra Pacureanu
Published in: Biomedical Optics Express, Issue 16, 2025, Page(s) 2047, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/boe.559263

Femtosecond laser preparation of resin embedded samples for correlative microscopy workflows in life sciences

Author(s): C Bosch, J Lindenau, A Pacureanu, CJ Peddie, M Majkut, AC Douglas, R Carzaniga, A Rack, L Collinson, AT Schaefer, H Stegmann
Published in: Applied Physiscs Letters, 2024, ISSN 1077-3118
Publisher: American Institute of Physics
DOI: 10.1101/2023.01.10.523473

Critical point drying of brain tissue for X-ray phase-contrast imaging

Author(s): Safe Khan, Jonas Albers, Artem Vorobyev, Yuxin Zhang, Jakob Reichmann, Angelika Svetlove, Fabio De Marco, Ksenia Denisova, Yikai Yang, Florent Seichepine, James O. Douglas, Elizabeth Duke, Peter Cloetens, Alexandra Pacureanu, Andreas T. Schaefer, Carles Bosch
Published in: Journal of Synchrotron Radiation, Issue 33, 2026, Page(s) 759-768, ISSN 1600-5775
Publisher: International Union of Crystallography (IUCr)
DOI: 10.1107/s1600577526001402

Experimental comparison of X-ray ptychographic and holographic nanotomography of metal-stained neuronal tissue

Author(s): Alexandra Pacureanu, Thomas Thies, Carles Bosch, Mirko Holler, Manuel Guizar-Sicairos, Elisabeth Müller, Joakim Reuteler, Dmitry Karpov, Andreas T. Schaefer, Peter Cloetens, Andreas Menzel, Ana Diaz
Published in: Optics Express, Issue 33, 2025, Page(s) 26915, ISSN 1094-4087
Publisher: Optical Society of America
DOI: 10.1364/oe.563186

Conference proceedings (3)

The XPRESS Challenge: Xray Projectomic Reconstruction -- Extracting Segmentation with Skeletons

Author(s): Nguyen, Tri; Narwani, Mukul; Larson, Mark; Li, Yicong; Xie, Shuhan; Pfister, Hanspeter; Wei, Donglai; Shavit, Nir; Mi, Lu; Pacureanu, Alexandra; Lee, Wei-Chung; Kuan, Aaron T.
Published in: 2023 IEEE 20th International Symposium on Biomedical Imaging (ISBI), Issue 1, 2023
Publisher: IEEE

MAE-XNT: A Foundation Model for Segmenting Neuronal Tissue VolumesGenerated with X-Ray Nanotomography

Author(s): Alfred Laugros, Sebastien Roig, Alexandra Pacureanu
Published in: Computer Vision and Pattern Recognition, 2026
Publisher: IEEE

X-Ray2EM: Uncertainty-Aware Cross-Modality Image Reconstruction from X-Ray to Electron Microscopy in Connectomics

Author(s): Yicong Li, Yaron Meirovitch, Aaron T. Kuan, Jasper S. Phelps, Alexandra Pacureanu, Wei-Chung Allen Lee, Nir Shavit, Lu Mi
Published in: 2023 IEEE 20th International Symposium on Biomedical Imaging (ISBI), 2023, Page(s) 1-5
Publisher: IEEE
DOI: 10.1109/isbi53787.2023.10230759

Other (2)

Self-supervised image restoration in coherent X-ray neuronal microscopy

Author(s): Alfred Laugros, Peter Cloetens, Carles Bosch, Richard Schoonhoven, Liam Pavlovic, Aaron T. Kuan, Jayde Livingstone, Yuxin Zhang, Minsu Kim, Allard Hendriksen, Mirko Holler, Adrian A. Wanner, Anthony Azevedo, K. Joost Batenburg, John C. Tuthill, Wei-Chung Allen Lee, Andreas T. Schaefer, Nicola Vigano, Alexandra Pacureanu
Published in: bioRxiv, 2026
Publisher: openRxiv
DOI: 10.1101/2025.02.10.633538

Structure-Function Mapping of Olfactory Bulb Circuits with Synchrotron X-ray Nanotomography

Author(s): Yuxin Zhang, Carles Bosch, Tobias Ackels, Alfred Laugros, Anne Bonnin, Jayde Livingstone, Carsten Waltenberg, Manuel Berning, Sina Tootoonian, Mihaly Kollo, Andrea Nathansen, Norman Rzepka, Peter Cloetens, Alexandra Pacureanu, Andreas T. Schaefer
Published in: bioRxiv, 2026
Publisher: openRxiv
DOI: 10.1101/2025.04.24.650439