Bright, coherent and focused light to resolve neural circuits

Informazioni relative al progetto

BRILLIANCE

ID dell’accordo di sovvenzione: 852455

DOI

10.3030/852455

Progetto chiuso

Data della firma CE 28 Febbraio 2020

Data di avvio 1 Marzo 2020

Data di completamento 28 Febbraio 2026

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 430 275,00

Contributo UE

€ 1 430 275,00

Coordinato da

EUROPEAN SYNCHROTRON RADIATION FACILITY
France

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Open Research Data Pilot (1)

Data Management Plan

Open Research Data Pilot

Pubblicazioni

Peer reviewed articles (10)

Dense neuronal reconstruction through X-ray holographic nano-tomography

Autori: Aaron T. Kuan, Jasper S. Phelps, Logan A. Thomas, Tri M. Nguyen, Julie Han, Chiao-Lin Chen, Anthony W. Azevedo, John C. Tuthill, Jan Funke, Peter Cloetens, Alexandra Pacureanu, Wei-Chung Allen Lee
Pubblicato in: Nature Neuroscience, Numero 23/12, 2020, Pagina/e 1637-1643, ISSN 1097-6256
Editore: Nature Publishing Group
DOI: 10.1038/s41593-020-0704-9

Functional and multiscale 3D structural investigation of brain tissue through correlative in vivo physiology, synchrotron microtomography and volume electron microscopy

Autori: Carles Bosch, Tobias Ackels, Alexandra Pacureanu, Yuxin Zhang, Christopher J. Peddie, Manuel Berning, Norman Rzepka, Marie-Christine Zdora, Isabell Whiteley, Malte Storm, Anne Bonnin, Christoph Rau, Troy Margrie, Lucy Collinson & Andreas T. Schaefer
Pubblicato in: Nature Communications, Numero 20411723, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-30199-6

Sample Preparation and Warping Accuracy for Correlative Multimodal Imaging in the Mouse Olfactory Bulb Using 2-Photon, Synchrotron X-Ray and Volume Electron Microscopy

Autori: Yuxin Zhang, Tobias Ackels, Alexandra Pacureanu, Marie-Christine Zdora, Anne Bonnin, Andreas T Schaefer, Carles Bosch
Pubblicato in: Frontiers in Cell and Developmental Biology, Numero 2296634X, 2022, ISSN 2296-634X
Editore: Frontiers
DOI: 10.3389/fcell.2022.880696

Biomechanical origins of proprioceptor feature selectivity and topographic maps in the Drosophila leg

Autori: Akira Mamiya, Anne Sustar, Igor Siwanowicz, Yanyan Qi, Tzu-Chiao Lu, Pralaksha Gurung, Chenghao Chen, Jasper S. Phelps, Aaron T. Kuan, Alexandra Pacureanu, Wei-Chung Allen Lee, Hongjie Li, Natasha Mhatre, John C. Tuthill
Pubblicato in: Neuron, Numero 111, 2024, Pagina/e 3230-3243.e14, ISSN 0896-6273
Editore: Cell Press
DOI: 10.1016/j.neuron.2023.07.009

Nondestructive X-ray tomography of brain tissue ultrastructure

Autori: Carles Bosch, Tomas Aidukas, Mirko Holler, Alexandra Pacureanu, Elisabeth Müller, Christopher J. Peddie, Yuxin Zhang, Phil Cook, Lucy Collinson, Oliver Bunk, Andreas Menzel, Manuel Guizar-Sicairos, Gabriel Aeppli, Ana Diaz, Adrian A. Wanner, Andreas T. Schaefer
Pubblicato in: Nature Methods, Numero 22, 2025, Pagina/e 2631-2638, ISSN 1548-7091
Editore: Nature Publishing Group
DOI: 10.1038/s41592-025-02891-0

Connectomic reconstruction of a female Drosophila ventral nerve cord

Autori: Anthony Azevedo, Ellen Lesser, Jasper S. Phelps, Brandon Mark, Leila Elabbady, Sumiya Kuroda, Anne Sustar, Anthony Moussa, Avinash Khandelwal, Chris J. Dallmann, Sweta Agrawal, Su-Yee J. Lee, Brandon Pratt, Andrew Cook, Kyobi Skutt-Kakaria, Stephan Gerhard, Ran Lu, Nico Kemnitz, Kisuk Lee, Akhilesh Halageri, Manuel Castro, Dodam Ih, Jay Gager, Marwan Tammam, Sven Dorkenwald, Forrest Collman, Casey
Pubblicato in: Nature, Numero 631, 2024, Pagina/e 360-368, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-024-07389-x

Scaling up X-ray holographic nanotomography for neuronal tissue imaging

Autori: Jayde Livingstone, Carles Bosch, Aaron T. Kuan, Lucas Benoït, Paolo Busca, Thierry Martin, Mohd F. E. B. Mazri, Wangchu Xiang, Wei-Chung Allen Lee, Andreas T. Schaefer, Peter Cloetens, Alexandra Pacureanu
Pubblicato in: Biomedical Optics Express, Numero 16, 2025, Pagina/e 2047, ISSN 2156-7085
Editore: The Optical Society
DOI: 10.1364/boe.559263

Femtosecond laser preparation of resin embedded samples for correlative microscopy workflows in life sciences

Autori: C Bosch, J Lindenau, A Pacureanu, CJ Peddie, M Majkut, AC Douglas, R Carzaniga, A Rack, L Collinson, AT Schaefer, H Stegmann
Pubblicato in: Applied Physiscs Letters, 2024, ISSN 1077-3118
Editore: American Institute of Physics
DOI: 10.1101/2023.01.10.523473

Critical point drying of brain tissue for X-ray phase-contrast imaging

Autori: Safe Khan, Jonas Albers, Artem Vorobyev, Yuxin Zhang, Jakob Reichmann, Angelika Svetlove, Fabio De Marco, Ksenia Denisova, Yikai Yang, Florent Seichepine, James O. Douglas, Elizabeth Duke, Peter Cloetens, Alexandra Pacureanu, Andreas T. Schaefer, Carles Bosch
Pubblicato in: Journal of Synchrotron Radiation, Numero 33, 2026, Pagina/e 759-768, ISSN 1600-5775
Editore: International Union of Crystallography (IUCr)
DOI: 10.1107/s1600577526001402

Experimental comparison of X-ray ptychographic and holographic nanotomography of metal-stained neuronal tissue

Autori: Alexandra Pacureanu, Thomas Thies, Carles Bosch, Mirko Holler, Manuel Guizar-Sicairos, Elisabeth Müller, Joakim Reuteler, Dmitry Karpov, Andreas T. Schaefer, Peter Cloetens, Andreas Menzel, Ana Diaz
Pubblicato in: Optics Express, Numero 33, 2025, Pagina/e 26915, ISSN 1094-4087
Editore: Optical Society of America
DOI: 10.1364/oe.563186

Conference proceedings (3)

The XPRESS Challenge: Xray Projectomic Reconstruction -- Extracting Segmentation with Skeletons

Autori: Nguyen, Tri; Narwani, Mukul; Larson, Mark; Li, Yicong; Xie, Shuhan; Pfister, Hanspeter; Wei, Donglai; Shavit, Nir; Mi, Lu; Pacureanu, Alexandra; Lee, Wei-Chung; Kuan, Aaron T.
Pubblicato in: 2023 IEEE 20th International Symposium on Biomedical Imaging (ISBI), Numero 1, 2023
Editore: IEEE

MAE-XNT: A Foundation Model for Segmenting Neuronal Tissue VolumesGenerated with X-Ray Nanotomography

Autori: Alfred Laugros, Sebastien Roig, Alexandra Pacureanu
Pubblicato in: Computer Vision and Pattern Recognition, 2026
Editore: IEEE

X-Ray2EM: Uncertainty-Aware Cross-Modality Image Reconstruction from X-Ray to Electron Microscopy in Connectomics

Autori: Yicong Li, Yaron Meirovitch, Aaron T. Kuan, Jasper S. Phelps, Alexandra Pacureanu, Wei-Chung Allen Lee, Nir Shavit, Lu Mi
Pubblicato in: 2023 IEEE 20th International Symposium on Biomedical Imaging (ISBI), 2023, Pagina/e 1-5
Editore: IEEE
DOI: 10.1109/isbi53787.2023.10230759

Other (2)

Self-supervised image restoration in coherent X-ray neuronal microscopy

Autori: Alfred Laugros, Peter Cloetens, Carles Bosch, Richard Schoonhoven, Liam Pavlovic, Aaron T. Kuan, Jayde Livingstone, Yuxin Zhang, Minsu Kim, Allard Hendriksen, Mirko Holler, Adrian A. Wanner, Anthony Azevedo, K. Joost Batenburg, John C. Tuthill, Wei-Chung Allen Lee, Andreas T. Schaefer, Nicola Vigano, Alexandra Pacureanu
Pubblicato in: bioRxiv, 2026
Editore: openRxiv
DOI: 10.1101/2025.02.10.633538

Structure-Function Mapping of Olfactory Bulb Circuits with Synchrotron X-ray Nanotomography

Autori: Yuxin Zhang, Carles Bosch, Tobias Ackels, Alfred Laugros, Anne Bonnin, Jayde Livingstone, Carsten Waltenberg, Manuel Berning, Sina Tootoonian, Mihaly Kollo, Andrea Nathansen, Norman Rzepka, Peter Cloetens, Alexandra Pacureanu, Andreas T. Schaefer
Pubblicato in: bioRxiv, 2026
Editore: openRxiv
DOI: 10.1101/2025.04.24.650439