Bright, coherent and focused light to resolve neural circuits

Información del proyecto

BRILLIANCE

Identificador del acuerdo de subvención: 852455

DOI

10.3030/852455

Proyecto cerrado

Fecha de la firma de la CE 28 Febrero 2020

Fecha de inicio 1 Marzo 2020

Fecha de finalización 28 Febrero 2026

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 430 275,00

Aportación de la UE

€ 1 430 275,00

Coordinado por

EUROPEAN SYNCHROTRON RADIATION FACILITY
France

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Open Research Data Pilot (1)

Data Management Plan

Open Research Data Pilot

Publicaciones

Peer reviewed articles (10)

Dense neuronal reconstruction through X-ray holographic nano-tomography

Autores: Aaron T. Kuan, Jasper S. Phelps, Logan A. Thomas, Tri M. Nguyen, Julie Han, Chiao-Lin Chen, Anthony W. Azevedo, John C. Tuthill, Jan Funke, Peter Cloetens, Alexandra Pacureanu, Wei-Chung Allen Lee
Publicado en: Nature Neuroscience, Edición 23/12, 2020, Página(s) 1637-1643, ISSN 1097-6256
Editor: Nature Publishing Group
DOI: 10.1038/s41593-020-0704-9

Functional and multiscale 3D structural investigation of brain tissue through correlative in vivo physiology, synchrotron microtomography and volume electron microscopy

Autores: Carles Bosch, Tobias Ackels, Alexandra Pacureanu, Yuxin Zhang, Christopher J. Peddie, Manuel Berning, Norman Rzepka, Marie-Christine Zdora, Isabell Whiteley, Malte Storm, Anne Bonnin, Christoph Rau, Troy Margrie, Lucy Collinson & Andreas T. Schaefer
Publicado en: Nature Communications, Edición 20411723, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-30199-6

Sample Preparation and Warping Accuracy for Correlative Multimodal Imaging in the Mouse Olfactory Bulb Using 2-Photon, Synchrotron X-Ray and Volume Electron Microscopy

Autores: Yuxin Zhang, Tobias Ackels, Alexandra Pacureanu, Marie-Christine Zdora, Anne Bonnin, Andreas T Schaefer, Carles Bosch
Publicado en: Frontiers in Cell and Developmental Biology, Edición 2296634X, 2022, ISSN 2296-634X
Editor: Frontiers
DOI: 10.3389/fcell.2022.880696

Biomechanical origins of proprioceptor feature selectivity and topographic maps in the Drosophila leg

Autores: Akira Mamiya, Anne Sustar, Igor Siwanowicz, Yanyan Qi, Tzu-Chiao Lu, Pralaksha Gurung, Chenghao Chen, Jasper S. Phelps, Aaron T. Kuan, Alexandra Pacureanu, Wei-Chung Allen Lee, Hongjie Li, Natasha Mhatre, John C. Tuthill
Publicado en: Neuron, Edición 111, 2024, Página(s) 3230-3243.e14, ISSN 0896-6273
Editor: Cell Press
DOI: 10.1016/j.neuron.2023.07.009

Nondestructive X-ray tomography of brain tissue ultrastructure

Autores: Carles Bosch, Tomas Aidukas, Mirko Holler, Alexandra Pacureanu, Elisabeth Müller, Christopher J. Peddie, Yuxin Zhang, Phil Cook, Lucy Collinson, Oliver Bunk, Andreas Menzel, Manuel Guizar-Sicairos, Gabriel Aeppli, Ana Diaz, Adrian A. Wanner, Andreas T. Schaefer
Publicado en: Nature Methods, Edición 22, 2025, Página(s) 2631-2638, ISSN 1548-7091
Editor: Nature Publishing Group
DOI: 10.1038/s41592-025-02891-0

Connectomic reconstruction of a female Drosophila ventral nerve cord

Autores: Anthony Azevedo, Ellen Lesser, Jasper S. Phelps, Brandon Mark, Leila Elabbady, Sumiya Kuroda, Anne Sustar, Anthony Moussa, Avinash Khandelwal, Chris J. Dallmann, Sweta Agrawal, Su-Yee J. Lee, Brandon Pratt, Andrew Cook, Kyobi Skutt-Kakaria, Stephan Gerhard, Ran Lu, Nico Kemnitz, Kisuk Lee, Akhilesh Halageri, Manuel Castro, Dodam Ih, Jay Gager, Marwan Tammam, Sven Dorkenwald, Forrest Collman, Casey
Publicado en: Nature, Edición 631, 2024, Página(s) 360-368, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-024-07389-x

Scaling up X-ray holographic nanotomography for neuronal tissue imaging

Autores: Jayde Livingstone, Carles Bosch, Aaron T. Kuan, Lucas Benoït, Paolo Busca, Thierry Martin, Mohd F. E. B. Mazri, Wangchu Xiang, Wei-Chung Allen Lee, Andreas T. Schaefer, Peter Cloetens, Alexandra Pacureanu
Publicado en: Biomedical Optics Express, Edición 16, 2025, Página(s) 2047, ISSN 2156-7085
Editor: The Optical Society
DOI: 10.1364/boe.559263

Femtosecond laser preparation of resin embedded samples for correlative microscopy workflows in life sciences

Autores: C Bosch, J Lindenau, A Pacureanu, CJ Peddie, M Majkut, AC Douglas, R Carzaniga, A Rack, L Collinson, AT Schaefer, H Stegmann
Publicado en: Applied Physiscs Letters, 2024, ISSN 1077-3118
Editor: American Institute of Physics
DOI: 10.1101/2023.01.10.523473

Critical point drying of brain tissue for X-ray phase-contrast imaging

Autores: Safe Khan, Jonas Albers, Artem Vorobyev, Yuxin Zhang, Jakob Reichmann, Angelika Svetlove, Fabio De Marco, Ksenia Denisova, Yikai Yang, Florent Seichepine, James O. Douglas, Elizabeth Duke, Peter Cloetens, Alexandra Pacureanu, Andreas T. Schaefer, Carles Bosch
Publicado en: Journal of Synchrotron Radiation, Edición 33, 2026, Página(s) 759-768, ISSN 1600-5775
Editor: International Union of Crystallography (IUCr)
DOI: 10.1107/s1600577526001402

Experimental comparison of X-ray ptychographic and holographic nanotomography of metal-stained neuronal tissue

Autores: Alexandra Pacureanu, Thomas Thies, Carles Bosch, Mirko Holler, Manuel Guizar-Sicairos, Elisabeth Müller, Joakim Reuteler, Dmitry Karpov, Andreas T. Schaefer, Peter Cloetens, Andreas Menzel, Ana Diaz
Publicado en: Optics Express, Edición 33, 2025, Página(s) 26915, ISSN 1094-4087
Editor: Optical Society of America
DOI: 10.1364/oe.563186

Conference proceedings (3)

The XPRESS Challenge: Xray Projectomic Reconstruction -- Extracting Segmentation with Skeletons

Autores: Nguyen, Tri; Narwani, Mukul; Larson, Mark; Li, Yicong; Xie, Shuhan; Pfister, Hanspeter; Wei, Donglai; Shavit, Nir; Mi, Lu; Pacureanu, Alexandra; Lee, Wei-Chung; Kuan, Aaron T.
Publicado en: 2023 IEEE 20th International Symposium on Biomedical Imaging (ISBI), Edición 1, 2023
Editor: IEEE

MAE-XNT: A Foundation Model for Segmenting Neuronal Tissue VolumesGenerated with X-Ray Nanotomography

Autores: Alfred Laugros, Sebastien Roig, Alexandra Pacureanu
Publicado en: Computer Vision and Pattern Recognition, 2026
Editor: IEEE

X-Ray2EM: Uncertainty-Aware Cross-Modality Image Reconstruction from X-Ray to Electron Microscopy in Connectomics

Autores: Yicong Li, Yaron Meirovitch, Aaron T. Kuan, Jasper S. Phelps, Alexandra Pacureanu, Wei-Chung Allen Lee, Nir Shavit, Lu Mi
Publicado en: 2023 IEEE 20th International Symposium on Biomedical Imaging (ISBI), 2023, Página(s) 1-5
Editor: IEEE
DOI: 10.1109/isbi53787.2023.10230759

Other (2)

Self-supervised image restoration in coherent X-ray neuronal microscopy

Autores: Alfred Laugros, Peter Cloetens, Carles Bosch, Richard Schoonhoven, Liam Pavlovic, Aaron T. Kuan, Jayde Livingstone, Yuxin Zhang, Minsu Kim, Allard Hendriksen, Mirko Holler, Adrian A. Wanner, Anthony Azevedo, K. Joost Batenburg, John C. Tuthill, Wei-Chung Allen Lee, Andreas T. Schaefer, Nicola Vigano, Alexandra Pacureanu
Publicado en: bioRxiv, 2026
Editor: openRxiv
DOI: 10.1101/2025.02.10.633538

Structure-Function Mapping of Olfactory Bulb Circuits with Synchrotron X-ray Nanotomography

Autores: Yuxin Zhang, Carles Bosch, Tobias Ackels, Alfred Laugros, Anne Bonnin, Jayde Livingstone, Carsten Waltenberg, Manuel Berning, Sina Tootoonian, Mihaly Kollo, Andrea Nathansen, Norman Rzepka, Peter Cloetens, Alexandra Pacureanu, Andreas T. Schaefer
Publicado en: bioRxiv, 2026
Editor: openRxiv
DOI: 10.1101/2025.04.24.650439