Active Monitoring of Cancer As An Alternative To Surgery

Informazioni relative al progetto

CAST

ID dell’accordo di sovvenzione: 857894

DOI

10.3030/857894

Progetto chiuso

Data della firma CE 11 Settembre 2019

Data di avvio 1 Novembre 2019

Data di completamento 31 Ottobre 2024

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 4 057 658,68

Contributo UE

€ 4 057 658,68

Coordinato da

STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (1)

website

Pubblicazioni

Peer reviewed articles (33)

In Vivo Imaging Evaluation of Fluorescence Intensity at Tail Emission of Near-Infrared-I (NIR-I) Fluorophores in a Porcine Model

Autori: Rodríguez-Luna MR, Okamoto N, Al-Taher M, Keller DS, Cinelli L, Hoskere Ashoka A, Klymchenko AS, Marescaux J, Diana M.
Pubblicato in: Life, 2022, ISSN 2075-1729
Editore: MDPI
DOI: 10.3390/life12081123

Submucosal Regrowths after Watch and Wait in Rectal Cancer: A Case Series

Autori: Ilaria Prata; Sofieke J. D. Temmink; Shirin Shahbazi Feshtali; Alexander L. Vahrmeijer; Stijn Crobach; Elke E. M. Peters; Jurjen J. Boonstra; Fabian A. Holman; Koen C. M. J. Peeters
Pubblicato in: Annals of Case Reports, Numero 4, 2023, ISSN 2474-1655
Editore: Annals of Clinical Case Reports
DOI: 10.29011/2574-7754.101180

Design of Nanoparticles in Cancer Therapy Based on Tumor Microenvironment Properties

Autori: Mahdavi Firouzabadi, Bita; Maria Joseph, Joice; Censi, Roberta; Di Martino, Piera
Pubblicato in: Pharmaceutics, Numero 9, 2022, ISSN 2078-2489
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14122708

Contact X-ray Brachytherapy as a sole treatment in selected patients with early rectal cancer - Multi-centre study

Autori: Wah Than N, Mark Pritchard D, Hughes DM, Shing Yu K, Minnaar HS, Dhadda A, Mills J, Folkesson J, Radu C, Duckworth CA, Wong H, Ul Haq M, Sripadam R, Halling-Brown MD, Stewart AJ, Sun Myint A.
Pubblicato in: Clinical and Translational Radiation Oncology, 2024, ISSN 2405-6308
Editore: Elsevier
DOI: 10.1016/j.ctro.2024.100851

Nanotechnology as a Versatile Tool for 19F-MRI Agent's Formulation: A Glimpse into the Use of Perfluorinated and Fluorinated Compounds in Nanoparticles

Autori: Joice Maria Joseph; Maria Rosa Gigliobianco; Bita Mahdavi Firouzabadi; Roberta Censi; Piera Di Martino
Pubblicato in: Pharmaceutics, Numero 14, 2022, ISSN 1424-8247
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14020382

Contact X-ray brachytherapy (CXB) as a salvage treatment for rectal cancer patients who developed local tumor re-growth after watch-and-wait approach

Autori: Than NW, Pritchard DM, Duckworth CA, Hughes DM, Wong H, Sripadam R, Myint AS
Pubblicato in: Journal of Contemporary Brachytherapy, 2024, ISSN 1689-832X
Editore: Termedia
DOI: 10.5114/jcb.2024.139049

Simultaneous, Multi-Channel, Near-Infrared Fluorescence Visualization of Mesenteric Lymph Nodes Using Indocyanine Green and Methylene Blue: A Demonstration in a Porcine Model.

Autori: Okamoto N, Al-Difaie Z, Scheepers MHMC, Heuvelings DJI, Rodríguez-Luna MR, Marescaux J, Diana M, Stassen LPS, Bouvy ND, Al-Taher M.
Pubblicato in: Diagnostics (Basel), 2023, ISSN 2075-4418
Editore: MDPI
DOI: 10.3390/diagnostics13081469

Computer-Assisted Differentiation between Colon-Mesocolon and Retroperitoneum Using Hyperspectral Imaging (HSI) Technology

Autori: Okamoto N, Rodríguez-Luna MR, Bencteux V, Al-Taher M, Cinelli L, Felli E, Urade T, Nkusi R, Mutter D, Marescaux J, Hostettler A, Collins T, Diana M.
Pubblicato in: Diagnostics (Basel), 2022, ISSN 2075-4418
Editore: MDPI
DOI: 10.3390/diagnostics12092225

MALDI imaging combined with two-photon microscopy reveals local differences in the heterogeneity of colorectal cancer

Autori: Arora B, Ajinkya K, Markus MA, Ramos-Gomes F, Bohnenberger H, Ströbel P, Alves F & Klein O.
Pubblicato in: NPJ Imagiing, 2024, ISSN 2948-197X
Editore: Nature Portfolio (subsidiary of Springer Nature)
DOI: 10.1038/s44303-024-00041-3

Results of a diagnostic imaging audit in a randomised clinical trial in rectal cancer highlight the importance of careful planning and quality control

Autori: Prata I, Eriksson M, Krdzalic J, Kranenbarg EM, Roodvoets AGH, Beets-Tan R, van de Velde CJH, van Etten B, Hospers GAP, Glimelius B, Nilsson PJ, Marijnen CAM, Peeters KCMJ, Blomqvist LK
Pubblicato in: Insights into Imaging, 2024, ISSN 1869-4101
Editore: Springer Science and Business Media Deutschland GmbH
DOI: 10.1186/s13244-023-01552-0

Hyperspectral Imaging in Major Hepatectomies: Preliminary Results from the Ex-Machyna Trial

Autori: Felli E, Cinelli L, Bannone E, Giannone F, Muttillo EM, Barberio M, Keller DS, Rodríguez-Luna MR, Okamoto N, Collins T, Hostettler A, Schuster C, Mutter D, Pessaux P, Marescaux J, Gioux S, Felli E, Diana M.
Pubblicato in: Cancers, 2022, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14225591

An automated deep learning pipeline for EMVI classification and response prediction of rectal cancer using baseline MRI: a multi-centre study

Autori: Cai L, Lambregts DMJ, Beets GL, Mass M, Pooch EHP, Guérendel C, Beets-Tan RGH, Benson S.
Pubblicato in: npj Precision Oncology, 2024, ISSN 2397-768X
Editore: Springer Nature
DOI: 10.1038/s41698-024-00516-x

Nanoparticles targeting hematopoietic stem and progenitor cells: Multimodal carriers for the treatment of hematological diseases

Autori: Cruz LJ, Rezaei S, Grosveld F, Philipsen S, Eich C.
Pubblicato in: Frontiers in Genome Editing, 2022, ISSN 2673-3439
Editore: Frontiers media
DOI: 10.3389/fgeed.2022.1030285

Label-free quantification of imaging features in the extracellular matrix of left and right-sided colon cancer tissues

Autori: Arora B, Kulkarni A, Markus MA, Ströbel P, Bohnenberger H, Alves F, Ramos-Gomes F.
Pubblicato in: Scientific Reports, 2024, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-024-58231-3

Watch and wait after neoadjuvant treatment in rectal cancer: comparison of outcomes in patients with and without a complete response at first reassessment in the International Watch & Wait Database (IWWD)

Autori: Temmink SJD, Peeters KCMJ, Bahadoer RR, Kranenbarg EM, Roodvoets AGH, Melenhorst J, Burger JWA, Wolthuis A, Renehan AG, Figueiredo NL, Pares O, Martling A, Perez RO, Beets GL, van de Velde CJH, Nilsson PJ; International Watch & Wait Database (IWWD) Consortium.
Pubblicato in: British Journal of Surgery, 2023, ISSN 1365-2168
Editore: Wiley
DOI: 10.1093/bjs/znad051

miR-34c-3p targets CDK1 a synthetic lethality partner of KRAS in non-small cell lung cancer

Autori: Francesco Palma, Alessandra Affinito, Silvia Nuzzo, Giuseppina Roscigno, Iolanda Scognamiglio, Francesco Ingenito, Lola Martinez, Monica Franzese, Mario Zanfardino, Andrea Soricelli, Alfonso Fiorelli, Gerolama Condorelli, Cristina Quintavalle
Pubblicato in: Cancer Gene Therapy, 2020, ISSN 0929-1903
Editore: Nature Publishing Group
DOI: 10.1038/s41417-020-00224-1

Endoglin/CD105-Based Imaging of Cancer and Cardiovascular Diseases: A Systematic Review

Autori: Vincent Q. Sier, Joost R. van der Vorst, Paul H. A. Quax, Margreet R. de Vries, Elham Zonoobi, Alexander L. Vahrmeijer, Ilona A. Dekkers, Lioe-Fee de Geus-Oei, Anke M. Smits, Weibo Cai, Cornelis F. M. Sier, Marie José T. H. Goumans, Lukas J. A. C. Hawinkels
Pubblicato in: International Journal of Molecular Sciences, Numero 22/9, 2021, Pagina/e 4804, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22094804

Modulating the Crosstalk between the Tumor and the Microenvironment Using SiRNA: A Flexible Strategy for Breast Cancer Treatment

Autori: Giuseppina Roscigno, Iolanda Scognamiglio, Francesco Ingenito, Rosario Vincenzo Chianese, Francesco Palma, Alan Chan, Gerolama Condorelli
Pubblicato in: Cancers, Numero 12/12, 2020, Pagina/e 3744, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12123744

Endoglin/CD105-Based Imaging of Cancer and Cardiovascular Diseases: A Systematic Review

Autori: Elham zonoobi
Pubblicato in: Molecular Sciences, Numero 3, 2021, ISSN 1424-8247
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.5281/zenodo.6594333

Clinical prediction models assessing response to radiotherapy for rectal cancer: protocol for a systematic review

Autori: Margarita Karageorgou; David M. Hughes; Arthur Sun Myint; D. Mark Pritchard; Laura J. Bonnett
Pubblicato in: Diagnostic and prognostic research, Numero 2, 2022, ISSN 1471-2458
Editore: BioMed Central
DOI: 10.1186/s41512-022-00132-y

Complete response rates in rectal cancer: Temporal changes over a decade in a population-based nationwide cohort

Autori: Temmink SJD, Martling A, Angenete E, Nilsson PJ.
Pubblicato in: European journal of surgical oncology, 2023, ISSN 0748-7983
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.ejso.2023.106991

Contact X-ray Brachytherapy (CXB) as a boost therapy after neoadjuvant (chemo)radiation in high-risk locally advanced rectal cancer

Autori: Ngu Wah Than, D. Mark Pritchard, David M. Hughes, Carrie. A. Duckworth, Helen Wong, Muneeb Ul Haq, Rajaram Sripadam, Arthur Sun Myint
Pubblicato in: International Journal of Radiation Oncology*Biology*Physics, 2024, ISSN 0360-3016
Editore: Elsevier BV
DOI: 10.1016/j.ijrobp.2024.11.113

CEA, EpCAM, αvβ6 and uPAR Expression in Rectal Cancer Patients with a Pathological Complete Response after Neoadjuvant Therapy

Autori: Daan Linders , Marion Deken , Maxime van der Valk , Willemieke Tummers , Shadhvi Bhairosingh , Dennis Schaap , Gesina van Lijnschoten , Elham Zonoobi , Peter Kuppen , Cornelis van de Velde , Alexander Vahrmeijer , Arantza Farina Sarasqueta , Cornelis Sier , Denise Hilling
Pubblicato in: Diagnostics (Basel), 2021, ISSN 2075-4418
Editore: MDPI
DOI: 10.3390/diagnostics11030516

miR-216a Acts as a Negative Regulator of Breast Cancer by Modulating Stemness Properties and Tumor Microenvironment

Autori: Giuseppina Roscigno, Assunta Cirella, Alessandra Affinito, Cristina Quintavalle, Iolanda Scognamiglio, Francesco Palma, Francesco Ingenito, Silvia Nuzzo, Francesca De Micco, Antonio Cuccuru, Renato Thomas, Gerolama Condorelli
Pubblicato in: International Journal of Molecular Sciences, Numero 21/7, 2020, Pagina/e 2313, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21072313

Redox-Sensitive and Hyaluronic Acid-Functionalized Nanoparticles for Improving Breast Cancer Treatment by Cytoplasmic 17α-Methyltestosterone Delivery

Autori: Somayeh Rezaei, Soheila Kashanian, Yadollah Bahrami, Luis J. Cruz, Marjan Motiei
Pubblicato in: Molecules, Numero 25/5, 2020, Pagina/e 1181, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules25051181

Trident: A dual oxygenation and fluorescence imaging platform for realtime and quantitative surgical guidance.

Autori: Ségaud S, Baratelli L, Felli E, Bannone E, Cinelli L, Rodríguez-Luna MR, Okamoto N, Keller DS, de Mathelin M, Lecler S, Diana M and Gioux S
Pubblicato in: Front. Photonics, 2022, ISSN 2673-6853
Editore: Frontiers Media
DOI: 10.3389/fphot.2022.1032776

Colorectal polyps: Targets for fluorescence-guided endoscopy to detect high-grade dysplasia and T1 colorectal cancer

Autori: Dekkers N, Zonoobi E, Dang H, Warmerdam MI, Crobach S, Langers AMJ, van der Kraan J, Hilling DE, Peeters KCMJ, Holman FA, Vahrmeijer AL, Sier CFM, Hardwick JCH, Boonstra JJ.
Pubblicato in: United European Gastroenterol J, 2022, ISSN 2050-6414
Editore: Wiley
DOI: 10.1002/ueg2.12375

Erythrocyte-cancer hybrid membrane-coated reduction-sensitive nanoparticles for enhancing chemotherapy efficacy in breast cancer

Autori: Rezaei S, de Araújo Júnior RF, da Silva ILG, Schomann T, Eich C, Cruz LJ.
Pubblicato in: Biomaterials Advances, 2023, ISSN 2772-9508
Editore: Elsevier
DOI: 10.1016/j.bioadv.2023.213456

Multifunctional Role of Lipids in Modulating the Tumorigenic Properties of 4T1 Breast Cancer Cells

Autori: Yuanyuan He; Somayeh Rezaei; Raimundo Fernandes de Araújo Júnior; Luis J. Cruz; Christina Eich
Pubblicato in: International Journal of Molecular Sciences; Volume 23; Numero 8; Pages: 4240, Numero 22, 2022, ISSN 1424-8247
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23084240

Quantification of bowel ischaemia using real-time multispectral Single Snapshot Imaging of Optical Properties (SSOP)

Autori: María Rita Rodríguez-Luna; Nariaki Okamoto; Lorenzo Cinelli; Luca Baratelli; Silvère Ségaud; Adriana Rodríguez-Gómez; Deborah S. Keller; Elham Zonoobi; Elisa Bannone; Jacques Marescaux; Michele Diana; Sylvain Gioux
Pubblicato in: Crossref, Numero 11, 2022, ISSN 0930-2794
Editore: Springer Verlag
DOI: 10.1007/s00464-022-09764-z

Single Snapshot Imaging of Optical Properties (SSOP) for Perfusion Assessment during Gastric Conduit Creation for Esophagectomy: An Experimental Study on Pigs

Autori: inelli L, Felli E, Baratelli L, Ségaud S, Baiocchini A, Okamoto N, Rodríguez-Luna MR, Elmore U, Rosati R, Partelli S, Marescaux J, Gioux S, Diana M
Pubblicato in: Cancers, 2021, ISSN 2072-6694
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers13236079

Watch and wait after a clinical complete response in rectal cancer patients younger than 50 years

Autori: Renu R. Bahadoer, Koen C. M. J. Peeters, Geerard L. Beets, Nuno L. Figueiredo, Esther Bastiaannet, Alexander Vahrmeijer, Sofieke J. D. Temmink, W. M. Elma Meershoek-Klein Kranenbarg, Annet G. H. Roodvoets, Angelita Habr-Gama, Rodrigo O. Perez, Cornelis J. H van de Velde, Denise E. Hilling
Pubblicato in: British Journal of Surgery, Numero 00071323, 2021, ISSN 0007-1323
Editore: John Wiley & Sons Inc.
DOI: 10.5281/zenodo.6550575

Sequence of Contact X-ray Brachytherapy (CXB) and External BeamRadiation (EBRT) in organ-preserving treatment for small rectal cancer

Autori: Than NW, Pritchard DM, Hughes DM, Duckworth CA, Wong H, Haq MU, Sripadam R, Myint AS.
Pubblicato in: Radiotherapy and Oncology, 2024, ISSN 0167-8140
Editore: Elsevier BV
DOI: 10.1016/j.radonc.2024.110465

Other (2)

Critical appraisal of the economic evidence for a watch-and-wait strategy in people with clinical complete response following neoadjuvant chemoradiotherapy for rectal cancer: a systematic review

Autori: Thapa, Shabnam; Payne, Katherine; Thokala, Praveen; Malcomson, Lee; Renehan, Andrew G
Pubblicato in: Numero 10, 2022
Editore: NIHR
DOI: 10.5281/zenodo.7550214

Improving Rectal Tumor Segmentation with Anomaly Fusion Derived from Anatomical Inpainting: A Multicenter Study

Autori: Lishan Cai, Mohamed A. Abdelatty, Luyi Han, Doenja M. J. Lambregts, Joost van Griethuysen, Eduardo Pooch, Regina G.H. Beets-Tan, Sean Benson, Joren Brunekreef, Jonas Teuwen
Pubblicato in: medRxiv, 2024
Editore: CSHL
DOI: 10.1101/2024.10.15.24315517

Conference proceedings (4)

Protein interaction with biocompatible and biodegradable novel nanohydrogels

Autori: Gigliobianco, Maria rosa; Mahdavi Firouzabadi, Bita; Censi, Roberta; Di Martino, Piera
Pubblicato in: Numero 7, 2022
Editore: Biopharmaceutics And Pharmaceutical Technology
DOI: 10.5281/zenodo.6641669

Economic evidence for a watch-and-wait strategy in patients with clinical complete response following neoadjuvant chemoradiotherapy for rectal cancer: a systematic review and critical appraisal

Autori: Thapa, Shabnam; Payne, Katherine; Thokala, Praveen; Malcomson, Lee; Renehan, Andrew G
Pubblicato in: Numero 3, 2022
Editore: The university of Manchester
DOI: 10.5281/zenodo.7510197

An improved automatic system for aiding the detection of colon polyps using deep learning

Autori: Lishan Cai; Regina Beets-Tan; Sean Benson
Pubblicato in: 2021, ISBN 978-1-6654-0358-0
Editore: IEEE
DOI: 10.1109/bhi50953.2021.9508557

Value Based Assessment Frameworks for Oncology: implications for valuing the outcomes for watch-and-wait after clinical complete response in rectal cancer (ValCoRe)

Autori: Thapa, Shabnam; Payne, Katherine; Thokala, Praveen; Malcomson, Lee; Renehan, Andrew G
Pubblicato in: Numero 9, 2022
Editore: The university of Manchester
DOI: 10.5281/zenodo.7510315