What makes a successfull pathogen? Understanding the impact of cell-to-cell heterogeneity in chromatin structure on infection and adaptation

Informazioni relative al progetto

Cell2Cell

ID dell’accordo di sovvenzione: 860675

DOI

10.3030/860675

Progetto chiuso

Data della firma CE 11 Settembre 2019

Data di avvio 1 Novembre 2019

Data di completamento 30 Aprile 2024

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 3 832 859,30

Contributo UE

€ 3 832 859,30

Coordinato da

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Other (6)

Potential inputs for Policy feedback

Consortium should include any relevant information, results, activities who could contribute to any policy development in their domain. This information could then be used for policy feedback purposes.

Summer school (Spetses)

Summer school with invited speakers held

Information flyer complete

Flyer information and design completed

Network logo designed

Cooperate image designed

Public Engagement progress review

Public Engagement progress review completed

Final conference / Career Day (Munich)

Final conference with invited speakers, modules in imaging (module 4: Microfluidics), NGS (ATAC-seq & ChIP-seq), Data Analysis (module 5: review of key aspects) and Career Day

Websites, patent fillings, videos etc. (1)

Website online

Cell2Cell network website design completed and online

Pubblicazioni

Peer reviewed articles (9)

The molecular grammar of protein disorder guiding genome-binding locations

Autori: Felix Jonas, Miri Carmi, Beniamin Krupkin, Joseph Steinberger, Sagie Brodsky, Tamar Jana, Naama Barkai
Pubblicato in: Nucleic Acids Research, Numero Vol. 51, Numero 10, 2023, Pagina/e 4831-4844, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkad184

Cell-to-Cell Heterogeneity in Trypanosomes

Autori: Vanessa Luzak, Lara López-Escobar, T. Nicolai Siegel, Luisa M. Figueiredo
Pubblicato in: Annual Review of Microbiology, Numero 75/1, 2021, Pagina/e 107-128, ISSN 0066-4227
Editore: Annual Reviews, Inc.
DOI: 10.1146/annurev-micro-040821-012953

The inner nuclear membrane protein Lem2 coordinates RNA degradation at the nuclear periphery

Autori: Lucía Martín Caballero, Matías Capella, Ramón Ramos Barrales, Nikolay Dobrev, Thomas van Emden, Yasuhiro Hirano, Vishnu N. Suma Sreechakram, Sabine Fischer-Burkart, Yasuha Kinugasa, Alicia Nevers, Mathieu Rougemaille, Irmgard Sinning, Tamás Fischer, Yasushi Hiraoka & Sigurd Braun
Pubblicato in: Nature Structural & Molecular Biology, Numero Vol. 29, 2022, Pagina/e 910-921, ISSN 1545-9993
Editore: Nature Publishing Group
DOI: 10.1038/s41594-022-00831-6

The 3-phosphoinositide-dependent protein kinase 1 is an essential upstream activator of protein kinase A in malaria parasites

Autori: Eva Hitz, Natalie Wiedemar, Armin Passecker, Beatriz A. S. Graça, Christian Scheurer, Sergio Wittlin, Nicolas M. B. Brancucci, Ioannis Vakonakis, Pascal Mäser, Till S. Voss
Pubblicato in: PLoS Biology, Numero 19(12), 2021, ISSN 1545-7885
Editore: Plos
DOI: 10.1371/journal.pbio.3001483

A genome-wide map of DNA replication at single-molecule resolution in the malaria parasite Plasmodium falciparum

Autori: Francis Isidore Garcia Totañes, Jonas Gockel, Sarah E. Chapman, Richárd Bártfai, Michael A. Boemo, Catherine J. Merrick
Pubblicato in: Nucleic Acids Research, Numero Volume 51, Numero 6, 2023, Pagina/e 2709-2724, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gkad093

m6A landscape is more pervasive when Trypanosoma brucei exits the cell cycle

Autori: Lúcia Serra, Sara Silva Pereira, Idálio J. Viegas, Henrique Machado, Lara López-Escobar, Luísa M. Figueiredo
Pubblicato in: Biomedical Journal, 2024, ISSN 0346-251X
Editore: Pergamon Press Ltd.
DOI: 10.1101/2024.02.23.581781

Continuous distribution of cancer cells in the cell cycle unveiled by AI-segmented imaging of 37,000 HeLa FUCCI cells

Autori: Hamid Cheraghi, Kinga Dóra Kovács, Inna Székács, Robert Horvath, Bálint Szabó
Pubblicato in: Heliyon, Numero Volume 10, Numero 9, 2024, ISSN 2405-8440
Editore: Londen: Elsevier Ltd.
DOI: 10.1016/j.heliyon.2024.e30239

The troubled puberty of malaria parasites

Autori: Jonas Gockel, Till S. Voss, Richárd Bártfai
Pubblicato in: Trends in Parasitology, Numero Volume 39, Numero 3, 2023, Pagina/e 155-157, ISSN 1097-4172
Editore: Cell Press
DOI: 10.1016/j.pt.2023.01.006

Slow growing behavior in African trypanosomes during adipose tissue colonization

Autori: Sandra Trindade, Mariana de Niz, Mariana Costa-Sequeira, Tiago Bizarra-Rebelo, Fábio Bento, Mario Dejung, Marta Valido Narciso, Lara López-Escobar, João Ferreira, Falk Butter, Frédéric Bringaud, Erida Gjini, Luisa M. Figueiredo
Pubblicato in: Nature Communications, Numero 13, Article number: 7548, 2022, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-022-34622-w

Other (2)

A systematic quantitative approach comprehensively defines domain-specific functional pathways linked to Schizosaccharomyces pombe heterochromatin regulation

Autori: Abubakar Muhammad, Zsuzsa Sarkadi, Thomas van Emden, Agnisrota Mazumder, Matias Capella, Gergely Fekete, Vishnu N. Suma Sreechakram, Bassem Al-Sady, Balázs Papp, Ramón Ramos Barrales, Sigurd Braun
Pubblicato in: bioRxiv, 2024
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.02.13.579970

High-resolution scRNA-seq reveals genomic determinants of antigen expression hierarchy in African Trypanosomes

Autori: Kirsty R McWilliam, Zhibek Keneskhanova, Raul O Cosentino, Atai Dobrynin, Jaclyn E Smith, Ines Subota, Monica R Mugnier, Maria Colome-Tatche, T Nicolai Siegel
Pubblicato in: bioRxiv, 2024
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.03.22.586247