What makes a successfull pathogen? Understanding the impact of cell-to-cell heterogeneity in chromatin structure on infection and adaptation

Rezultaty

Consortium should include any relevant information, results, activities who could contribute to any policy development in their domain. This information could then be used for policy feedback purposes.

Summer school (Spetses)

Summer school with invited speakers held

Information flyer complete

Flyer information and design completed

Network logo designed

Cooperate image designed

Public Engagement progress review

Public Engagement progress review completed

Final conference / Career Day (Munich)

Final conference with invited speakers, modules in imaging (module 4: Microfluidics), NGS (ATAC-seq & ChIP-seq), Data Analysis (module 5: review of key aspects) and Career Day

Website online

Cell2Cell network website design completed and online

Publikacje

The molecular grammar of protein disorder guiding genome-binding locations

Autorzy: Felix Jonas, Miri Carmi, Beniamin Krupkin, Joseph Steinberger, Sagie Brodsky, Tamar Jana, Naama Barkai
Opublikowane w: Nucleic Acids Research, Numer Vol. 51, Numer 10, 2023, Strona(/y) 4831-4844, ISSN 0305-1048
Wydawca: Oxford University Press
DOI: 10.1093/nar/gkad184

Cell-to-Cell Heterogeneity in Trypanosomes

Autorzy: Vanessa Luzak, Lara López-Escobar, T. Nicolai Siegel, Luisa M. Figueiredo
Opublikowane w: Annual Review of Microbiology, Numer 75/1, 2021, Strona(/y) 107-128, ISSN 0066-4227
Wydawca: Annual Reviews, Inc.
DOI: 10.1146/annurev-micro-040821-012953

The inner nuclear membrane protein Lem2 coordinates RNA degradation at the nuclear periphery

Autorzy: Lucía Martín Caballero, Matías Capella, Ramón Ramos Barrales, Nikolay Dobrev, Thomas van Emden, Yasuhiro Hirano, Vishnu N. Suma Sreechakram, Sabine Fischer-Burkart, Yasuha Kinugasa, Alicia Nevers, Mathieu Rougemaille, Irmgard Sinning, Tamás Fischer, Yasushi Hiraoka & Sigurd Braun
Opublikowane w: Nature Structural & Molecular Biology, Numer Vol. 29, 2022, Strona(/y) 910-921, ISSN 1545-9993
Wydawca: Nature Publishing Group
DOI: 10.1038/s41594-022-00831-6

The 3-phosphoinositide-dependent protein kinase 1 is an essential upstream activator of protein kinase A in malaria parasites

Autorzy: Eva Hitz, Natalie Wiedemar, Armin Passecker, Beatriz A. S. Graça, Christian Scheurer, Sergio Wittlin, Nicolas M. B. Brancucci, Ioannis Vakonakis, Pascal Mäser, Till S. Voss
Opublikowane w: PLoS Biology, Numer 19(12), 2021, ISSN 1545-7885
Wydawca: Plos
DOI: 10.1371/journal.pbio.3001483

A genome-wide map of DNA replication at single-molecule resolution in the malaria parasite Plasmodium falciparum

Autorzy: Francis Isidore Garcia Totañes, Jonas Gockel, Sarah E. Chapman, Richárd Bártfai, Michael A. Boemo, Catherine J. Merrick
Opublikowane w: Nucleic Acids Research, Numer Volume 51, Numer 6, 2023, Strona(/y) 2709-2724, ISSN 0305-1048
Wydawca: Oxford University Press
DOI: 10.1093/nar/gkad093

m6A landscape is more pervasive when Trypanosoma brucei exits the cell cycle

Autorzy: Lúcia Serra, Sara Silva Pereira, Idálio J. Viegas, Henrique Machado, Lara López-Escobar, Luísa M. Figueiredo
Opublikowane w: Biomedical Journal, 2024, ISSN 0346-251X
Wydawca: Pergamon Press Ltd.
DOI: 10.1101/2024.02.23.581781

Continuous distribution of cancer cells in the cell cycle unveiled by AI-segmented imaging of 37,000 HeLa FUCCI cells

Autorzy: Hamid Cheraghi, Kinga Dóra Kovács, Inna Székács, Robert Horvath, Bálint Szabó
Opublikowane w: Heliyon, Numer Volume 10, Numer 9, 2024, ISSN 2405-8440
Wydawca: Londen: Elsevier Ltd.
DOI: 10.1016/j.heliyon.2024.e30239

The troubled puberty of malaria parasites

Autorzy: Jonas Gockel, Till S. Voss, Richárd Bártfai
Opublikowane w: Trends in Parasitology, Numer Volume 39, Numer 3, 2023, Strona(/y) 155-157, ISSN 1097-4172
Wydawca: Cell Press
DOI: 10.1016/j.pt.2023.01.006

Slow growing behavior in African trypanosomes during adipose tissue colonization

Autorzy: Sandra Trindade, Mariana de Niz, Mariana Costa-Sequeira, Tiago Bizarra-Rebelo, Fábio Bento, Mario Dejung, Marta Valido Narciso, Lara López-Escobar, João Ferreira, Falk Butter, Frédéric Bringaud, Erida Gjini, Luisa M. Figueiredo
Opublikowane w: Nature Communications, Numer 13, Article number: 7548, 2022, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-022-34622-w

A systematic quantitative approach comprehensively defines domain-specific functional pathways linked to Schizosaccharomyces pombe heterochromatin regulation

Autorzy: Abubakar Muhammad, Zsuzsa Sarkadi, Thomas van Emden, Agnisrota Mazumder, Matias Capella, Gergely Fekete, Vishnu N. Suma Sreechakram, Bassem Al-Sady, Balázs Papp, Ramón Ramos Barrales, Sigurd Braun
Opublikowane w: bioRxiv, 2024
Wydawca: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.02.13.579970

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