Descripción del proyecto
Detener el auge de la enfermedad renal crónica requiere una mejora del conocimiento de sus mecanismos
Según el estudio de 2010 sobre la carga mundial de las enfermedades («2010 Global Burden of Disease report», en inglés), la enfermedad renal crónica (ERC) figuraba en vigesimoséptima posición de la lista de causas de muerte en todo el mundo en 1990 y subió hasta la decimoctava en 2010. Este incremento espectacular fue superado solamente por el VIH y el SIDA. Actualmente, no se conocen bien los mecanismos del avance de la ERC, ni por qué esta enfermedad progresa más rápidamente en unas personas que en otras. TrainCKDis apoya a quince jóvenes investigadores que trabajan en proyectos de investigación centrados en ámbitos clave necesarios para colmar lagunas en la caracterización de la ERC. Una mejor comprensión contribuirá a la identificación de biomarcadores para un diagnóstico temprano de los pacientes que corren un mayor riesgo, al seguimiento de su progresión, así como a ayudar al desarrollo de tratamientos.
Objetivo
Chronic kidney disease (CKD) is recognized as an increasing global health problem. It currently affects 10-15% of the worldwide population, is associated with impaired quality of life and reduced life expectancy, and represents a significant burden for health care budgets.
CKD is characterized by the progressive decline of renal function. Little is known about the mechanisms underlying this progression and the genetic factors that predispose patients to different rate of progression. Even worse, there is no reliable biomarkers capable to identify patients at risk of fast progression and treatments able to halt CKD progression.
Understanding the physiopathology of CKD is therefore a prerequisite for the development of efficient preventive strategies and diagnostic tools.
With this goal in mind, TrainCKDis will provide an innovative, multidisciplinary, and intersectoral training programme, able to prepare top-level young scientists to develop creative solutions for CKD. The proposed 15 research projects will address key challenges: i) the identification of genetic and epigenetic modifiers that predispose patients to CKD progression, ii) the identification of pathways and biomarkers for monitoring CKD progression and iii) the identification of novel therapeutic targets to improve the limited treatments for CKD.
TrainCKDis gathers top European laboratories, companies, hospitals, and associations involved in the treatment of CKD.
Early Stage Researchers (ESRs) will thus benefit from an outstanding interdisciplinary platform integrating nephrology, epidemiology, genetics, cell biology, high-throughput screening, system biology, and metabolomics experts, as well as experimental animal models and unique human biobanks. Moreover, ESRs will be trained in disseminating results through modern channels of communication. Finally, TrainCKDis will provide ESRs with intersectoral and transferable training for efficient career development in both the academic and private sectors.
Ámbito científico
- medical and health sciencesbasic medicinepharmacology and pharmacydrug discovery
- natural sciencesbiological sciencesgenetics
- medical and health scienceshealth sciencespublic healthepidemiology
- natural sciencesbiological sciencescell biology
- medical and health sciencesclinical medicinenephrologykidney diseases
Palabras clave
Programa(s)
Régimen de financiación
MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinador
75006 Paris
Francia