Skip to main content
European Commission logo
italiano italiano
CORDIS - Risultati della ricerca dell’UE
CORDIS

Multidisciplinary Training in Chronic Kidney Disease: from genetic modifiers to drug discovery

Descrizione del progetto

Fermare l’ascesa della malattia renale cronica richiede maggiori conoscenze sui meccanismi

In base allo studio Global Burden of Disease del 2010, la malattia renale cronica (MRC) si è classificata al 27º posto nell'elenco delle cause di decesso in tutto il mondo nel 1990 ed è salita al 18º posto nel 2010. Questo drastico innalzamento è stato secondo solo a quello di HIV e AIDS. Non sono ben compresi, ad oggi, i meccanismi di progressione della malattia e tra questi il motivo per cui la MRC in alcune persone progredisce più velocemente che in altre. TrainCKDis sta supportando 15 giovani ricercatori nel loro lavoro su progetti di ricerca che si rivolgono a settori essenziali per colmare le lacune nella caratterizzazione della MRC. Una maggiore comprensione contribuirà all’individuazione di biomarcatori per la diagnosi precoce nei pazienti maggiormente a rischio, al monitoraggio della progressione e favorirà lo sviluppo di trattamenti.

Obiettivo

Chronic kidney disease (CKD) is recognized as an increasing global health problem. It currently affects 10-15% of the worldwide population, is associated with impaired quality of life and reduced life expectancy, and represents a significant burden for health care budgets.
CKD is characterized by the progressive decline of renal function. Little is known about the mechanisms underlying this progression and the genetic factors that predispose patients to different rate of progression. Even worse, there is no reliable biomarkers capable to identify patients at risk of fast progression and treatments able to halt CKD progression.
Understanding the physiopathology of CKD is therefore a prerequisite for the development of efficient preventive strategies and diagnostic tools.
With this goal in mind, TrainCKDis will provide an innovative, multidisciplinary, and intersectoral training programme, able to prepare top-level young scientists to develop creative solutions for CKD. The proposed 15 research projects will address key challenges: i) the identification of genetic and epigenetic modifiers that predispose patients to CKD progression, ii) the identification of pathways and biomarkers for monitoring CKD progression and iii) the identification of novel therapeutic targets to improve the limited treatments for CKD.
TrainCKDis gathers top European laboratories, companies, hospitals, and associations involved in the treatment of CKD.
Early Stage Researchers (ESRs) will thus benefit from an outstanding interdisciplinary platform integrating nephrology, epidemiology, genetics, cell biology, high-throughput screening, system biology, and metabolomics experts, as well as experimental animal models and unique human biobanks. Moreover, ESRs will be trained in disseminating results through modern channels of communication. Finally, TrainCKDis will provide ESRs with intersectoral and transferable training for efficient career development in both the academic and private sectors.

Coordinatore

UNIVERSITE PARIS CITE
Contribution nette de l'UE
€ 549 604,08
Indirizzo
85 BD SAINT GERMAIN
75006 Paris
Francia

Mostra sulla mappa

Regione
Ile-de-France Ile-de-France Paris
Tipo di attività
Higher or Secondary Education Establishments
Collegamenti
Costo totale
€ 549 604,08

Partecipanti (9)