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Disentangling metaphase chromosome organisation one chromosome at a time

Project description

Studying the architecture of metaphase chromosomes

Chromosomes acquire their most compact state just before separation during metaphase. The EU-funded MONOCHROME project aims to develop an approach that allows real-time super-resolution imaging and manipulation of entire non-fixed metaphase chromosomes under near-physiological conditions. Researchers propose to obtain quantitative images of the proteins that establish the architecture of metaphase chromosomes and analyse the internal protein dynamics at the molecular level. The introduction of force-induced expansion microscopy, together with advanced labelling and imaging techniques, will make possible the validation and correction of the current models of metaphase organisation as well as an exploration of the physical properties of chromosomes and chromosome separation dynamics.

Host institution

STICHTING VU
Net EU contribution
€ 1 997 284,00
Address
De Boelelaan 1105
1081 HV Amsterdam
Netherlands

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Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Beneficiaries (1)

STICHTING VU
Netherlands
Net EU contribution
€ 1 997 284,00
Address
De Boelelaan 1105
1081 HV Amsterdam

See on map

Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00