Description du projet
L’ADN circulaire en tant que nouveau biomarqueur de diagnostic
L’ADN circulaire constitue depuis peu un nouveau biomarqueur pour de nombreux types de cancers et de troubles inflammatoires. Toutefois, nous ne disposons pas de technologies permettant de détecter l’ADN circulaire ou de générer des modèles de maladies appropriés. Pour répondre à ce problème, le projet CIRCULAR VISION, financé par l’UE, se servira du cancer du poumon et de la maladie inflammatoire chronique de l’intestin pour étudier le lien entre la maladie et l’ADN circulaire. Les scientifiques combineront la microfluidique, le séquençage de l’ADN et la bioinformatique afin d’identifier de nouveaux biomarqueurs et de développer des approches innovantes pour le diagnostic du cancer. La technologie ainsi produite ouvrira la voie à de futures recherches ainsi qu’au développement de nouveaux médicaments dans ce domaine.
Objectif
Many human diseases, including cancers and inflammatory disorders, are associated with the production of ‘circular DNA’ from chromosomes. These molecules have potential as biomarkers, and in the case of cancers are potential drivers of disease progression. However, the technology for detecting circular DNA and for creating disease models is lacking, meaning we cannot explore their potential use in diagnostics. CIRCULAR VISIONs goal is to explore the new opportunities circular DNA creates in early diagnosis and monitoring of disease, particularly screening, and to create an experimental system to understand the link between disease and circular DNA.
CIRCULAR VISION will explore this brand new territory by creating highly sensitive whole genome screens for circular DNA that correlate with disease, using lung cancer (LC) and inflammatory bowel disease (IBD) as model examples. We develop and combine novel methods in molecular biology, microfluidics, DNA sequencing and bioinformatics in order to identify new diagnostic markers. Such markers for IBD and LC will then be adapted to clinical diagnosis and prognosis using advanced image analysis and cytometry methods. Finally, CIRCULAR VISION will show the causal link between circular DNA and cancer, by producing disease models with oncogenes on circular DNA.
CIRCULAR VISION assembles key pioneers in the emerging field of circular DNA with leading clinical experts and key commercial players in cytometry and genomics. We are convinced that our technology has broad applications in early noninvasive diagnosis of cancer and monitoring of inflammatory diseases. We believe our technology will lay the foundation for future research into circular DNA biology and spur future drug development.
Champ scientifique
- medical and health sciencesbasic medicinepharmacology and pharmacydrug discovery
- natural sciencesbiological sciencesgeneticsDNA
- medical and health sciencesclinical medicineoncologylung cancer
- medical and health sciencesclinical medicinegastroenterologyinflammatory bowel disease
- natural sciencesbiological sciencesgeneticsgenomes
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Programme(s)
Régime de financement
RIA - Research and Innovation actionCoordinateur
1165 Kobenhavn
Danemark