Descripción del proyecto
El ADN circular como un nuevo biomarcador de diagnóstico
El ADN circular está emergiendo como un nuevo biomarcador para diversos tipos de cáncer y trastornos inflamatorios. Sin embargo, carecemos de la tecnología necesaria para detectar el ADN circular y para generar modelos patológicos adecuados. Con el fin de hacer frente a este problema, el proyecto financiado con fondos europeos CIRCULAR VISION utilizará el cáncer de pulmón y la enfermedad inflamatoria intestinal para investigar el vínculo entre la enfermedad y el ADN circular. Los científicos combinarán la microfluídica, la secuenciación del ADN y la bioinformática para identificar nuevos biomarcadores y desarrollar enfoques novedosos para el diagnóstico del cáncer. La tecnología generada allanará el camino para la investigación futura y para el desarrollo de fármacos en este campo.
Objetivo
Many human diseases, including cancers and inflammatory disorders, are associated with the production of ‘circular DNA’ from chromosomes. These molecules have potential as biomarkers, and in the case of cancers are potential drivers of disease progression. However, the technology for detecting circular DNA and for creating disease models is lacking, meaning we cannot explore their potential use in diagnostics. CIRCULAR VISIONs goal is to explore the new opportunities circular DNA creates in early diagnosis and monitoring of disease, particularly screening, and to create an experimental system to understand the link between disease and circular DNA.
CIRCULAR VISION will explore this brand new territory by creating highly sensitive whole genome screens for circular DNA that correlate with disease, using lung cancer (LC) and inflammatory bowel disease (IBD) as model examples. We develop and combine novel methods in molecular biology, microfluidics, DNA sequencing and bioinformatics in order to identify new diagnostic markers. Such markers for IBD and LC will then be adapted to clinical diagnosis and prognosis using advanced image analysis and cytometry methods. Finally, CIRCULAR VISION will show the causal link between circular DNA and cancer, by producing disease models with oncogenes on circular DNA.
CIRCULAR VISION assembles key pioneers in the emerging field of circular DNA with leading clinical experts and key commercial players in cytometry and genomics. We are convinced that our technology has broad applications in early noninvasive diagnosis of cancer and monitoring of inflammatory diseases. We believe our technology will lay the foundation for future research into circular DNA biology and spur future drug development.
Ámbito científico
- medical and health sciencesbasic medicinepharmacology and pharmacydrug discovery
- natural sciencesbiological sciencesgeneticsDNA
- medical and health sciencesclinical medicineoncologylung cancer
- medical and health sciencesclinical medicinegastroenterologyinflammatory bowel disease
- natural sciencesbiological sciencesgeneticsgenomes
Palabras clave
Programa(s)
Convocatoria de propuestas
Consulte otros proyectos de esta convocatoriaConvocatoria de subcontratación
H2020-FETOPEN-2018-2019-2020-01
Régimen de financiación
RIA - Research and Innovation actionCoordinador
1165 Kobenhavn
Dinamarca