Descrizione del progetto
DNA circolare come nuovo biomarcatore diagnostico
Il DNA circolare sta emergendo come nuovo biomarcatore per molti tipi di cancro e disturbi infiammatori. Tuttavia, manca ancora la tecnologia in grado di rilevare il DNA circolare e generare modelli di malattia appropriati. Per affrontare questo problema, il progetto CIRCULAR VISION, finanziato dall’UE, utilizzerà il cancro ai polmoni e la malattia infiammatoria intestinale per studiare il collegamento tra malattia e DNA circolare. Gli scienziati combineranno microfluidica, sequenziamento del DNA e bioinformatica per identificare nuovi biomarcatori e sviluppare nuovi approcci per la diagnosi del cancro. La tecnologia generata aprirà la strada alla ricerca futura e allo sviluppo di farmaci nel campo.
Obiettivo
Many human diseases, including cancers and inflammatory disorders, are associated with the production of ‘circular DNA’ from chromosomes. These molecules have potential as biomarkers, and in the case of cancers are potential drivers of disease progression. However, the technology for detecting circular DNA and for creating disease models is lacking, meaning we cannot explore their potential use in diagnostics. CIRCULAR VISIONs goal is to explore the new opportunities circular DNA creates in early diagnosis and monitoring of disease, particularly screening, and to create an experimental system to understand the link between disease and circular DNA.
CIRCULAR VISION will explore this brand new territory by creating highly sensitive whole genome screens for circular DNA that correlate with disease, using lung cancer (LC) and inflammatory bowel disease (IBD) as model examples. We develop and combine novel methods in molecular biology, microfluidics, DNA sequencing and bioinformatics in order to identify new diagnostic markers. Such markers for IBD and LC will then be adapted to clinical diagnosis and prognosis using advanced image analysis and cytometry methods. Finally, CIRCULAR VISION will show the causal link between circular DNA and cancer, by producing disease models with oncogenes on circular DNA.
CIRCULAR VISION assembles key pioneers in the emerging field of circular DNA with leading clinical experts and key commercial players in cytometry and genomics. We are convinced that our technology has broad applications in early noninvasive diagnosis of cancer and monitoring of inflammatory diseases. We believe our technology will lay the foundation for future research into circular DNA biology and spur future drug development.
Campo scientifico
- medical and health sciencesbasic medicinepharmacology and pharmacydrug discovery
- natural sciencesbiological sciencesgeneticsDNA
- medical and health sciencesclinical medicineoncologylung cancer
- medical and health sciencesclinical medicinegastroenterologyinflammatory bowel disease
- natural sciencesbiological sciencesgeneticsgenomes
Parole chiave
Programma(i)
Invito a presentare proposte
Vedi altri progetti per questo bandoBando secondario
H2020-FETOPEN-2018-2019-2020-01
Meccanismo di finanziamento
RIA - Research and Innovation actionCoordinatore
1165 Kobenhavn
Danimarca