ATRIAL FIBRILLATION INTEGRATED APPROACH IN FRAIL, MULTIMORBID, AND POLYMEDICATED OLDER PEOPLE

Projektinformationen

AFFIRMO

ID Finanzhilfevereinbarung: 899871

DOI

10.3030/899871

EK-Unterschriftsdatum 3 Februar 2021

Startdatum 1 Mai 2021

Enddatum 31 Oktober 2026

Finanziert unter

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Gesamtkosten

€ 5 998 753,25

EU-Beitrag

€ 5 998 753,25

Koordiniert durch

AALBORG UNIVERSITET
Denmark

CORDIS bietet Links zu öffentlichen Ergebnissen und Veröffentlichungen von HORIZONT-Projekten.

Links zu Ergebnissen und Veröffentlichungen von RP7-Projekten sowie Links zu einigen Typen spezifischer Ergebnisse wie Datensätzen und Software werden dynamisch von OpenAIRE abgerufen.

Leistungen

Documents, reports (7)

Report of the survey results

Report summarising the results of the survey conducted in five countries (Italy, Spain, Denmark, Romania, and the UK) to identify the needs and key quality performance indicators of patients and carers, and healthcare professionals, in relation to managing multimorbidity.

Model documentation

Detailed methods documentation, including epidemiological and economics inputs and evidence used to inform the model.

High-level requirements document

This document will facilitate the software architecture desgins and this contain the early project requirements as co-morbidities are identified.

Report on the qualitative data

Report presenting the findings of the qualitative work (focus groups and interviews) with mulitmorbid patients and their caregivers.

Digital platform quality assessment

This will include a review of user feedback and conformity with data protection guidelines.

Report on the needs and QPIs

eport of a standard set of outcomes and quality performance indicators and the tools/measures for these variables to inform the randomised controlled trial .

Microsimulation model

Report of a microsimulation model to perform effectiveness and cost effectiveness analyses.

Websites, patent fillings, videos etc. (2)

Digital platform

The digital platform is the key deliverable for UNIMAN and will be used in the RCT.

Project public website

This is the public project website for general communication purposes, both internal and external. A responsive design will be used to ensure a versatile use also on mobile devices. The public website will present AFFIRMO activities and results to the general public fostering Stakeholder & public engagement that will take place throughout the life of the whole project to engage other researchers in the project activities and present.

Demonstrators, pilots, prototypes (1)

Interactive prototypes

The interactive prototypes will support requirements workshops and will allow us to present our understanding of requirements in an interactive way, without the need to deliver software to do so.

Other (1)

Software Requirements Specification

This is a document outlining the requirements of the digital platform. Requirements will be provided at a high-level via D5.1, with the software requirements specification providing a more detailed description

Veröffentlichungen

Peer reviewed articles (21)

Comorbidity patterns and the risk of injurious falls in older people with atrial fibrillation: Findings from a Swedish nation-wide population-based study

Autoren: Caterina Trevisan, Cecilia Damiano, Lu Dai, Amaia Calderón-Larrañaga, Jonas W. Wastesson, Kristina Johnell, Cheïma Amrouch, Graziano Onder, Alessandra Marengoni, Riccardo Proietti, Gregory Y H Lip, Søren P Johnsen, Mirko Petrovic, Davide Liborio Vetrano
Veröffentlicht in: European Journal of Internal Medicine, 2024, ISSN 0953-6205
Herausgeber: Elsevier BV
DOI: 10.1016/j.ejim.2024.11.011

The role of comorbidity and frailty in shaping the burden of atrial fibrillation: a multinational cross-sectional survey

Autoren: Adele Ravelli, Caterina Trevisan, José Miguel Rivera-Caravaca, Bruno Micael Zanforlini, Caterina Bosio, Guendalina Graffigna, Giuseppe Sergi, Gheorghe-Andrei Dan, Anca Rodica Dan, Vanessa Roldán, Francisco Marín Ortuno, Søren Paaske Johnsen, Mirko Petrovic, Davide Liborio Vetrano, Donato Giuseppe Leo, Deirdre A. Lane, null null, Søren Påske Johnsen, Riccardo Proietti, Pia Cordsen, Gregory Li
Veröffentlicht in: Scientific Reports, Ausgabe 16, 2026, ISSN 2045-2322
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41598-026-44800-1

Author Reply

Autoren: Vincenzo Rebba
Veröffentlicht in: Value in Health, Ausgabe 27, 2024, Seite(n) 1467, ISSN 1098-3015
Herausgeber: Blackwell Publishing Inc.
DOI: 10.1016/j.jval.2024.07.026

Informal Caregiving in Patients With Atrial Fibrillation and Multimorbidity: A Cross-European Study of Caregiver Burden, Health-Related Quality of Life, and Caregiver Engagement

Autoren: Caterina Bosio, Dilara Usta, Caterina Trevisan, Deirdre A. Lane, Guendalina Graffigna, null null
Veröffentlicht in: Journal of Cardiovascular Nursing, Ausgabe 41, 2026, Seite(n) E343-E353, ISSN 0889-4655
Herausgeber: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/jcn.0000000000001289

Potentially Clinically Significant Drug-Drug Interactions in Older Adults with Atrial Fibrillation and Multimorbidity: Prevalence, Correlates, and Association with Adverse Clinical Outcomes in a Swedish National Register-Based Study

Autoren: Cheima Amrouch, Davide Liborio Vetrano, Dirk De Bacquer, Nicola Ferri, Ine Simal, Cecilia Damiano, Lu Dai, Amaia Calderón-Larrañaga, Astrid D. H. Brys, Anton De Spiegeleer, Gregory Y. H. Lip, Søren P. Johnsen, Jonas W. Wastesson, Kristina Johnell, Delphine De Smedt, Mirko Petrovic
Veröffentlicht in: Cardiovascular Drugs and Therapy, Ausgabe 40, 2026, Seite(n) 1485-1502, ISSN 0920-3206
Herausgeber: Kluwer Academic Publishers
DOI: 10.1007/s10557-025-07825-8

Quality of life, care needs and priorities in atrial fibrillation: the impact of number and patterns of comorbidities

Autoren: Caterina Trevisan, Adele Ravelli, José Miguel Rivera-Caravaca, Bruno Micael Zanforlini, Giuseppe Sergi, Gheorghe-Andrei Dan, Anca Rodica Dan, Vanessa Roldán, Francisco Marín Ortuño, Søren Paaske Johnsen, Mirko Petrovic, Davide Liborio Vetrano, Donato Giuseppe Leo, Deirdre A. Lane, null null, Riccardo Proietti, Pia Cordsen, Gregory Lip, Deirdre Lane, Martin O’Flaherty, Carrol Gamble, Iain Bu
Veröffentlicht in: Quality of Life Research, Ausgabe 35, 2026, ISSN 0962-9343
Herausgeber: Kluwer Academic Publishers
DOI: 10.1007/s11136-025-04117-4

The Cost of Atrial Fibrillation: A Systematic Review

Autoren: Alessandra Buja, Vincenzo Rebba, Laura Montecchio, Giulia Renzo, Vincenzo Baldo, Silvia Cocchio, Nicola Ferri, Federico Migliore, Alessandro Zorzi, Brendan Collins, Cheïma Amrouch, Delphine De Smedt, Christodoulos Kypridemos, Mirko Petrovic, Martin O’Flaherty, Gregory Y.H. Lip
Veröffentlicht in: Value in Health, Ausgabe 27, 2024, Seite(n) 527-541, ISSN 1098-3015
Herausgeber: Blackwell Publishing Inc.
DOI: 10.1016/j.jval.2023.12.015

Key needs, quality performance indicators and outcomes for patients with atrial fibrillation and multimorbidity: The AFFIRMO study

Autoren: Donato Giuseppe Leo, Caterina Trevisan, Adele Ravelli, Trudie C. A. Lobban, Deirdre A. Lane, null null
Veröffentlicht in: PLOS ONE, Ausgabe 19, 2024, Seite(n) e0310106, ISSN 1932-6203
Herausgeber: Public Library of Science
DOI: 10.1371/journal.pone.0310106

Frailty increases the risk of hospitalization for atrial fibrillation in older adults: a population-based cohort study

Autoren: Caterina Trevisan, Chiara Ceolin, Davide Liborio Vetrano, Mirko Petrovic, Gregory Y.H. Lip, Iain Buchan, Marina De Rui, Giuseppe Sergi, Stefania Maggi, Marianna Noale, Søren Påske Johnsen, Riccardo Proietti, Pia Cordsen, Gregory Lip, Deirdre Lane, Martin O'Flaherty, Carrol Gamble, Iain Buchan, Christodoulos Kypridemos, Brendan Collins, Donato Leo, Mirko Petrovic, Delphine De Smedt, Stefanie De B
Veröffentlicht in: Nutrition, Metabolism and Cardiovascular Diseases, Ausgabe 35, 2025, Seite(n) 104159, ISSN 0939-4753
Herausgeber: Medikal Press s.r.l.
DOI: 10.1016/j.numecd.2025.104159

Potentially inappropriate prescribing in multimorbid and polymedicated older adults with AF: A Systematic Review and Meta-Analysis

Autoren: Cheima Amrouch, Delphine Vauterin, Souad Amrouch, Maxim Grymonprez, Lu Dai, Cecilia Damiano, Amaia Calderón-Larrañaga, Lies Lahousse, Dirk De Bacquer, Gregory Y. H. Lip, Davide L. Vetrano, Delphine De Smedt, Mirko Petrovic, null null
Veröffentlicht in: Drugs & Aging, Ausgabe 41, 2024, Seite(n) 13-30, ISSN 1170-229X
Herausgeber: Adis International Ltd.
DOI: 10.1007/s40266-023-01078-6

Potentially inappropriate prescribing in polymedicated older adults with atrial fibrillation and multimorbidity: a Swedish national register-based cohort study

Autoren: Cheima Amrouch, Davide Liborio Vetrano, Cecilia Damiano, Lu Dai, Amaia Calderón-Larrañaga, Maxim Grymonprez, Marco Proietti, Gregory Y. H. Lip, Søren P. Johnsen, Jonas W. Wastesson, Kristina Johnell, Delphine De Smedt, Mirko Petrovic
Veröffentlicht in: Frontiers in Pharmacology, Ausgabe 15, 2024, ISSN 1663-9812
Herausgeber: Frontiers Media S.A.
DOI: 10.3389/fphar.2024.1476464

Drug-Drug Interactions of Direct Oral Anticoagulants (DOACs): From Pharmacological to Clinical Practice

Autoren: Nicola Ferri, Elisa Colombo, Marco Tenconi, Ludovico Baldessin, Alberto Corsini
Veröffentlicht in: Pharmaceutics, Ausgabe 14, 2025, Seite(n) 1120, ISSN 1999-4923
Herausgeber: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14061120

Integrated care management and comprehensive geriatric assessment using a mHealth-based approach in older multimorbid patients with atrial fibrillation: the AFFIRMO cluster-randomised trial

Autoren: Gregory Y.H. Lip, Marco Proietti, John Ainsworth, Gheorghe-Andrei Dan, Lars Frost, Guendalina Graffigna, Deirdre A. Lane, Donata Lucci, Gianna Fabbri, Francisco Marin, Martin O'Flaherty, Mirko Petrovic, Tatjana S. Potpara, Riccardo Proietti, Alam Sanaullah, Mariya Tokmakova, Davide Liborio Vetrano, Søren Paaske Johnsen, Aldo Pietro Maggioni, Gregory Y.H. Lip, Søren Paaske Johnsen, Aldo Pietro Ma
Veröffentlicht in: The Lancet Regional Health - Europe, 2026, Seite(n) 101832, ISSN 2666-7762
Herausgeber: Elsevier BV
DOI: 10.1016/j.lanepe.2026.101832

High initial heart rate score is an independent predictor of new atrial high-rate episodes in pacemaker patients with sinus node dysfunction

Autoren: Katsuhide Hayashi, Haruhiko Abe, Brian Olshansky, Arjun D. Sharma, Paul W. Jones, Nicholas Wold, David Perschbacher, Ritsuko Kohno, Gregory.Y.H. Lip, Niraj Varma, Bruce L. Wilkoff
Veröffentlicht in: Heart Rhythm, Ausgabe 21, 2024, Seite(n) 2543-2551, ISSN 1547-5271
Herausgeber: Elsevier BV
DOI: 10.1016/j.hrthm.2024.06.046

Integrated care management for older multimorbid patients with atrial fibrillation: Rationale, design and baseline characteristics for the atrial fibrillation integrated approach in frail, multimorbid and polymedicated older people (AFFIRMO) trial

Autoren: Marco Proietti, Gregory Y.H. Lip, John Ainsworth, Gheorghe-Andrei Dan, Lars Frost, Guendalina Graffigna, Donata Lucci, Francisco Marin, Tatjana S. Potpara, Alam Sanaullah, Mariya Tokmakova, Søren Paaske Johnsen, Aldo Pietro Maggioni
Veröffentlicht in: American Heart Journal, Ausgabe 295, 2026, Seite(n) 107356, ISSN 0002-8703
Herausgeber: Mosby Inc.
DOI: 10.1016/j.ahj.2026.107356

Exploring patient engagement in atrial fibrillation with multimorbidity: impact on quality of life, medication adherence and healthcare perceptions—a multicountry cross-sectional study

Autoren: Caterina Bosio, Dilara Usta, Donato Leo, Caterina Trevisan, Deirdre Lane, Guendalina Graffigna
Veröffentlicht in: BMJ Open, Ausgabe 15, 2025, Seite(n) e094351, ISSN 2044-6055
Herausgeber: BMJ Publishing Group
DOI: 10.1136/bmjopen-2024-094351

Atrial Fibrillation and Transitions Across Functional States in Older Adults: A Longitudinal Multistate Model Analysis

Autoren: Marianna Noale, Chiara Ceolin, Mirko Petrovic, Gregory Y.H. Lip, Davide Liborio Vetrano, Chiara Curreri, Marina De Rui, Giuseppe Sergi, Stefania Maggi, Caterina Trevisan
Veröffentlicht in: Canadian Journal of Cardiology, Ausgabe 42, 2026, Seite(n) 1292-1303, ISSN 0828-282X
Herausgeber: Pulsus Group Inc.
DOI: 10.1016/j.cjca.2025.12.044

A multinational European network to implement integrated care in elderly multimorbid atrial fibrillation patients: the AFFIRMO Consortium

Autoren: Søren P Johnsen, Marco Proietti, Aldo P Maggioni, Gregory Y H Lip on behalf of the AFFIRMO Consortium and Investigators
Veröffentlicht in: European Heart Journal, Ausgabe Volume 43, 2022, Seite(n) 2916–2918, ISSN 0195-668X
Herausgeber: Oxford University Press
DOI: 10.1093/eurheartj/ehac265

Patient engagement in multimorbidity: a systematic review of patient-reported outcome measures

Autoren: Serena Barello, Gloria Anderson, Caterina Bosio, Deirdre A. Lane, Donato G. Leo, Trudie C. A. Lobban, Caterina Trevisan, Guendalina Graffigna
Veröffentlicht in: Frontiers in Psychology, Ausgabe 15, 2024, ISSN 1664-1078
Herausgeber: Frontiers Research Foundation
DOI: 10.3389/fpsyg.2024.1345117

Clinical and subclinical acute brain injury caused by invasive cardiovascular procedures

Autoren: Radosław Lenarczyk, Marco Proietti, Jan F. Scheitz, Dipen Shah, Eberhard Siebert, Diana A. Gorog, Jacek Kowalczyk, Nikolaos Bonaros, George Ntaios, Wolfram Doehner, Nicolas M. Van Mieghem, Sandor Nardai, Jan Kovac, Roland Fiszer, Roberto Lorusso, Eliano Navarese, Sergio Castrejón, Andrea Rubboli, José Miguel Rivera-Caravaca, Alaide Chieffo, Gregory Y. H. Lip
Veröffentlicht in: Nature Reviews Cardiology, Ausgabe 22, 2025, Seite(n) 273-303, ISSN 1759-5002
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41569-024-01076-0

Integrated Care for Atrial Fibrillation Using the ABC Pathway in the Prospective APHRS-AF Registry

Autoren: Tommaso Bucci, Marco Proietti, Alena Shantsila, Giulio Francesco Romiti, Wee-Siong Teo, Hyung-Wook Park, Wataru Shimizu, Hung-Fat Tse, Gregory Y.H. Lip, Tze-Fan Chao
Veröffentlicht in: JACC: Asia, Ausgabe 3, 2025, Seite(n) 580-591, ISSN 2772-3747
Herausgeber: Elsevier BV
DOI: 10.1016/j.jacasi.2023.04.008

Conference proceedings (1)

Quality of life in patients with atrial fibrillation and multimorbidity, and their caregivers: results from the AFFIRMO international online survey

Autoren: D Leo, C Trevisan, A Ravelli, G Graffigna, C Bosio, T Lobban, D Lane
Veröffentlicht in: Europace, Ausgabe 26, 2024, ISSN 1099-5129
Herausgeber: Oxford University Press
DOI: 10.1093/europace/euae102.260