ATRIAL FIBRILLATION INTEGRATED APPROACH IN FRAIL, MULTIMORBID, AND POLYMEDICATED OLDER PEOPLE

Informazioni relative al progetto

AFFIRMO

ID dell’accordo di sovvenzione: 899871

DOI

10.3030/899871

Data della firma CE 3 Febbraio 2021

Data di avvio 1 Maggio 2021

Data di completamento 31 Ottobre 2026

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale

€ 5 998 753,25

Contributo UE

€ 5 998 753,25

Coordinato da

AALBORG UNIVERSITET
Denmark

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (7)

Report of the survey results

Report summarising the results of the survey conducted in five countries (Italy, Spain, Denmark, Romania, and the UK) to identify the needs and key quality performance indicators of patients and carers, and healthcare professionals, in relation to managing multimorbidity.

Model documentation

Detailed methods documentation, including epidemiological and economics inputs and evidence used to inform the model.

High-level requirements document

This document will facilitate the software architecture desgins and this contain the early project requirements as co-morbidities are identified.

Report on the qualitative data

Report presenting the findings of the qualitative work (focus groups and interviews) with mulitmorbid patients and their caregivers.

Digital platform quality assessment

This will include a review of user feedback and conformity with data protection guidelines.

Report on the needs and QPIs

eport of a standard set of outcomes and quality performance indicators and the tools/measures for these variables to inform the randomised controlled trial .

Microsimulation model

Report of a microsimulation model to perform effectiveness and cost effectiveness analyses.

Websites, patent fillings, videos etc. (2)

Digital platform

The digital platform is the key deliverable for UNIMAN and will be used in the RCT.

Project public website

This is the public project website for general communication purposes, both internal and external. A responsive design will be used to ensure a versatile use also on mobile devices. The public website will present AFFIRMO activities and results to the general public fostering Stakeholder & public engagement that will take place throughout the life of the whole project to engage other researchers in the project activities and present.

Demonstrators, pilots, prototypes (1)

Interactive prototypes

The interactive prototypes will support requirements workshops and will allow us to present our understanding of requirements in an interactive way, without the need to deliver software to do so.

Other (1)

Software Requirements Specification

This is a document outlining the requirements of the digital platform. Requirements will be provided at a high-level via D5.1, with the software requirements specification providing a more detailed description

Pubblicazioni

Peer reviewed articles (19)

Comorbidity patterns and the risk of injurious falls in older people with atrial fibrillation: Findings from a Swedish nation-wide population-based study

Autori: Caterina Trevisan, Cecilia Damiano, Lu Dai, Amaia Calderón-Larrañaga, Jonas W. Wastesson, Kristina Johnell, Cheïma Amrouch, Graziano Onder, Alessandra Marengoni, Riccardo Proietti, Gregory Y H Lip, Søren P Johnsen, Mirko Petrovic, Davide Liborio Vetrano
Pubblicato in: European Journal of Internal Medicine, 2024, ISSN 0953-6205
Editore: Elsevier BV
DOI: 10.1016/j.ejim.2024.11.011

Quality of life in patients with atrial fibrillation and multimorbidity, and their caregivers: results from the AFFIRMO international online survey

Autori: D Leo, C Trevisan, A Ravelli, G Graffigna, C Bosio, T Lobban, D Lane
Pubblicato in: Europace, Numero 26, 2024, ISSN 1099-5129
Editore: Oxford University Press
DOI: 10.1093/europace/euae102.260

Author Reply

Autori: Vincenzo Rebba
Pubblicato in: Value in Health, Numero 27, 2024, Pagina/e 1467, ISSN 1098-3015
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.jval.2024.07.026

Potentially Clinically Significant Drug-Drug Interactions in Older Adults with Atrial Fibrillation and Multimorbidity: Prevalence, Correlates, and Association with Adverse Clinical Outcomes in a Swedish National Register-Based Study

Autori: Cheima Amrouch, Davide Liborio Vetrano, Dirk De Bacquer, Nicola Ferri, Ine Simal, Cecilia Damiano, Lu Dai, Amaia Calderón-Larrañaga, Astrid D. H. Brys, Anton De Spiegeleer, Gregory Y. H. Lip, Søren P. Johnsen, Jonas W. Wastesson, Kristina Johnell, Delphine De Smedt, Mirko Petrovic
Pubblicato in: Cardiovascular Drugs and Therapy, Numero 40, 2026, Pagina/e 1485-1502, ISSN 0920-3206
Editore: Kluwer Academic Publishers
DOI: 10.1007/s10557-025-07825-8

The Cost of Atrial Fibrillation: A Systematic Review

Autori: Alessandra Buja, Vincenzo Rebba, Laura Montecchio, Giulia Renzo, Vincenzo Baldo, Silvia Cocchio, Nicola Ferri, Federico Migliore, Alessandro Zorzi, Brendan Collins, Cheïma Amrouch, Delphine De Smedt, Christodoulos Kypridemos, Mirko Petrovic, Martin O’Flaherty, Gregory Y.H. Lip
Pubblicato in: Value in Health, Numero 27, 2024, Pagina/e 527-541, ISSN 1098-3015
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.jval.2023.12.015

Key needs, quality performance indicators and outcomes for patients with atrial fibrillation and multimorbidity: The AFFIRMO study

Autori: Donato Giuseppe Leo, Caterina Trevisan, Adele Ravelli, Trudie C. A. Lobban, Deirdre A. Lane, null null
Pubblicato in: PLOS ONE, Numero 19, 2024, Pagina/e e0310106, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0310106

Frailty increases the risk of hospitalization for atrial fibrillation in older adults: a population-based cohort study

Autori: Caterina Trevisan, Chiara Ceolin, Davide Liborio Vetrano, Mirko Petrovic, Gregory Y.H. Lip, Iain Buchan, Marina De Rui, Giuseppe Sergi, Stefania Maggi, Marianna Noale, Søren Påske Johnsen, Riccardo Proietti, Pia Cordsen, Gregory Lip, Deirdre Lane, Martin O'Flaherty, Carrol Gamble, Iain Buchan, Christodoulos Kypridemos, Brendan Collins, Donato Leo, Mirko Petrovic, Delphine De Smedt, Stefanie De B
Pubblicato in: Nutrition, Metabolism and Cardiovascular Diseases, Numero 35, 2025, Pagina/e 104159, ISSN 0939-4753
Editore: Medikal Press s.r.l.
DOI: 10.1016/j.numecd.2025.104159

Potentially inappropriate prescribing in multimorbid and polymedicated older adults with AF: A Systematic Review and Meta-Analysis

Autori: Cheima Amrouch, Delphine Vauterin, Souad Amrouch, Maxim Grymonprez, Lu Dai, Cecilia Damiano, Amaia Calderón-Larrañaga, Lies Lahousse, Dirk De Bacquer, Gregory Y. H. Lip, Davide L. Vetrano, Delphine De Smedt, Mirko Petrovic, null null
Pubblicato in: Drugs & Aging, Numero 41, 2024, Pagina/e 13-30, ISSN 1170-229X
Editore: Adis International Ltd.
DOI: 10.1007/s40266-023-01078-6

Potentially inappropriate prescribing in polymedicated older adults with atrial fibrillation and multimorbidity: a Swedish national register-based cohort study

Autori: Cheima Amrouch, Davide Liborio Vetrano, Cecilia Damiano, Lu Dai, Amaia Calderón-Larrañaga, Maxim Grymonprez, Marco Proietti, Gregory Y. H. Lip, Søren P. Johnsen, Jonas W. Wastesson, Kristina Johnell, Delphine De Smedt, Mirko Petrovic
Pubblicato in: Frontiers in Pharmacology, Numero 15, 2024, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fphar.2024.1476464

Drug-Drug Interactions of Direct Oral Anticoagulants (DOACs): From Pharmacological to Clinical Practice

Autori: Nicola Ferri, Elisa Colombo, Marco Tenconi, Ludovico Baldessin, Alberto Corsini
Pubblicato in: Pharmaceutics, Numero 14, 2025, Pagina/e 1120, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14061120

Integrated care management and comprehensive geriatric assessment using a mHealth-based approach in older multimorbid patients with atrial fibrillation: the AFFIRMO cluster-randomised trial

Autori: Gregory Y.H. Lip, Marco Proietti, John Ainsworth, Gheorghe-Andrei Dan, Lars Frost, Guendalina Graffigna, Deirdre A. Lane, Donata Lucci, Gianna Fabbri, Francisco Marin, Martin O'Flaherty, Mirko Petrovic, Tatjana S. Potpara, Riccardo Proietti, Alam Sanaullah, Mariya Tokmakova, Davide Liborio Vetrano, Søren Paaske Johnsen, Aldo Pietro Maggioni, Gregory Y.H. Lip, Søren Paaske Johnsen, Aldo Pietro Ma
Pubblicato in: The Lancet Regional Health - Europe, 2026, Pagina/e 101832, ISSN 2666-7762
Editore: Elsevier BV
DOI: 10.1016/j.lanepe.2026.101832

High initial heart rate score is an independent predictor of new atrial high-rate episodes in pacemaker patients with sinus node dysfunction

Autori: Katsuhide Hayashi, Haruhiko Abe, Brian Olshansky, Arjun D. Sharma, Paul W. Jones, Nicholas Wold, David Perschbacher, Ritsuko Kohno, Gregory.Y.H. Lip, Niraj Varma, Bruce L. Wilkoff
Pubblicato in: Heart Rhythm, Numero 21, 2024, Pagina/e 2543-2551, ISSN 1547-5271
Editore: Elsevier BV
DOI: 10.1016/j.hrthm.2024.06.046

Integrated care management for older multimorbid patients with atrial fibrillation: Rationale, design and baseline characteristics for the atrial fibrillation integrated approach in frail, multimorbid and polymedicated older people (AFFIRMO) trial

Autori: Marco Proietti, Gregory Y.H. Lip, John Ainsworth, Gheorghe-Andrei Dan, Lars Frost, Guendalina Graffigna, Donata Lucci, Francisco Marin, Tatjana S. Potpara, Alam Sanaullah, Mariya Tokmakova, Søren Paaske Johnsen, Aldo Pietro Maggioni
Pubblicato in: American Heart Journal, Numero 295, 2026, Pagina/e 107356, ISSN 0002-8703
Editore: Mosby Inc.
DOI: 10.1016/j.ahj.2026.107356

Exploring patient engagement in atrial fibrillation with multimorbidity: impact on quality of life, medication adherence and healthcare perceptions—a multicountry cross-sectional study

Autori: Caterina Bosio, Dilara Usta, Donato Leo, Caterina Trevisan, Deirdre Lane, Guendalina Graffigna
Pubblicato in: BMJ Open, Numero 15, 2025, Pagina/e e094351, ISSN 2044-6055
Editore: BMJ Publishing Group
DOI: 10.1136/bmjopen-2024-094351

Atrial Fibrillation and Transitions Across Functional States in Older Adults: A Longitudinal Multistate Model Analysis

Autori: Marianna Noale, Chiara Ceolin, Mirko Petrovic, Gregory Y.H. Lip, Davide Liborio Vetrano, Chiara Curreri, Marina De Rui, Giuseppe Sergi, Stefania Maggi, Caterina Trevisan
Pubblicato in: Canadian Journal of Cardiology, Numero 42, 2026, Pagina/e 1292-1303, ISSN 0828-282X
Editore: Pulsus Group Inc.
DOI: 10.1016/j.cjca.2025.12.044

A multinational European network to implement integrated care in elderly multimorbid atrial fibrillation patients: the AFFIRMO Consortium

Autori: Søren P Johnsen, Marco Proietti, Aldo P Maggioni, Gregory Y H Lip on behalf of the AFFIRMO Consortium and Investigators
Pubblicato in: European Heart Journal, Numero Volume 43, 2022, Pagina/e 2916–2918, ISSN 0195-668X
Editore: Oxford University Press
DOI: 10.1093/eurheartj/ehac265

Patient engagement in multimorbidity: a systematic review of patient-reported outcome measures

Autori: Serena Barello, Gloria Anderson, Caterina Bosio, Deirdre A. Lane, Donato G. Leo, Trudie C. A. Lobban, Caterina Trevisan, Guendalina Graffigna
Pubblicato in: Frontiers in Psychology, Numero 15, 2024, ISSN 1664-1078
Editore: Frontiers Research Foundation
DOI: 10.3389/fpsyg.2024.1345117

Clinical and subclinical acute brain injury caused by invasive cardiovascular procedures

Autori: Radosław Lenarczyk, Marco Proietti, Jan F. Scheitz, Dipen Shah, Eberhard Siebert, Diana A. Gorog, Jacek Kowalczyk, Nikolaos Bonaros, George Ntaios, Wolfram Doehner, Nicolas M. Van Mieghem, Sandor Nardai, Jan Kovac, Roland Fiszer, Roberto Lorusso, Eliano Navarese, Sergio Castrejón, Andrea Rubboli, José Miguel Rivera-Caravaca, Alaide Chieffo, Gregory Y. H. Lip
Pubblicato in: Nature Reviews Cardiology, Numero 22, 2025, Pagina/e 273-303, ISSN 1759-5002
Editore: Nature Publishing Group
DOI: 10.1038/s41569-024-01076-0

Integrated Care for Atrial Fibrillation Using the ABC Pathway in the Prospective APHRS-AF Registry

Autori: Tommaso Bucci, Marco Proietti, Alena Shantsila, Giulio Francesco Romiti, Wee-Siong Teo, Hyung-Wook Park, Wataru Shimizu, Hung-Fat Tse, Gregory Y.H. Lip, Tze-Fan Chao
Pubblicato in: JACC: Asia, Numero 3, 2025, Pagina/e 580-591, ISSN 2772-3747
Editore: Elsevier BV
DOI: 10.1016/j.jacasi.2023.04.008