Descrizione del progetto
Una soluzione innovativa per trattare le pazienti anziane affette da cancro al seno a rischio di cardiotossicità
I fattori correlati all’età e le comorbilità accrescono la vulnerabilità alla cardiotossicità delle pazienti anziane con cancro al seno durante il trattamento antitumorale. La mancanza di prassi consolidate e il preconcetto della fragilità di queste pazienti, sottorappresentate nelle sperimentazioni, possono condurre a interventi inappropriati o non sufficienti comportando esiti peggiori, deterioramento della qualità della vita e costi sanitari maggiori. Il progetto CARDIOCARE, finanziato dall’UE, si concentrerà sulla popolazione anziana con cancro al seno. Attraverso un approccio olistico che comprende applicazioni di sanità elettronica, sensori indossabili e biomarcatori, consentirà alle pazienti di prendere parte al loro processo di cura e di migliorare la loro salute fisica e mentale, contribuendo a un piano di cura personalizzato e a un adattamento psicologico alla malattia. Il progetto CARDIOCARE consentirà una stratificazione del rischio efficace grazie alla mitigazione della cardiotossicità e di eventi avversi, alla riduzione dell’ospedalizzazione al minimo e al miglioramento della qualità della vita.
Obiettivo
More than 50% of the newly diagnosed breast cancer patients are elderly and particularly susceptible to cardiotoxicity of cancer treatment due to age-related factors and prevalence of multiple co-morbidities. The cumulative effect of risk factors in the elderly patient resembles a “snowball effect”, where baseline age and cancer-related changes are exacerbated by direct therapy-induced cardiotoxicity, resulting to a multi-morbid state and mortality. Frailty and high risk of cardiotoxicity in this group may lead to inappropriate interventions and undertreatment, resulting in poorer outcomes, deterioration of QoL and increased healthcare costs. Considering, that older cancer patients are underrepresented in trials, new interdisciplinary and patient-oriented studies able to provide clinical guidelines and best practices for delivering quality care are needed.
CARDIOCARE will contribute to scale up a better management for the multimorbid elderly breast cancer patients. Innovative eHealth applications, coupled with sensors and wearables, will permit a consistent evaluation of the intrinsic capacity and by combining clinical and biological features, will provide a holistic approach to the management of cancer and his co-morbidities in the elderly population. This will allow the development of quality indicators for effective care pathways and allow a more informed approach to breast cancer patients with multimorbidity, training and education of caregivers and stakeholders to boost effectively elderly breast cancer patients along disease trajectory and cardiotoxicity. eHealth applications will increase the involvement and participation of the patients in their care process and self-management improving adherence to their individualized care plan, and a better psychological adaptation to their disease. Overall, the implementation of a comprehensive model for effective risk stratification will positively impact on QoL, adverse events, hospitalizations, and healthcare.
Campo scientifico
- medical and health scienceshealth scienceshealth care serviceseHealth
- social sciencessociologydemographymortality
- medical and health sciencesclinical medicineoncologybreast cancer
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensors
Parole chiave
Programma(i)
Argomento(i)
Invito a presentare proposte
Vedi altri progetti per questo bandoBando secondario
H2020-SC1-2020-Two-Stage-RTD
Meccanismo di finanziamento
RIA - Research and Innovation actionCoordinatore
45110 Ioannina
Grecia