Integrative mechanistic and multi-omics Modelling of Antigen Presentation to predict epitope dynamics

Información del proyecto

IMAP

Identificador del acuerdo de subvención: 945528

DOI

10.3030/945528

Fecha de la firma de la CE 13 Octubre 2020

Fecha de inicio 1 Abril 2021

Fecha de finalización 31 Marzo 2026

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 495 000,00

Aportación de la UE

€ 1 495 000,00

Coordinado por

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (14)

The maintenance of oocytes in the mammalian ovary involves extreme protein longevity

Autores: Katarina Harasimov, Rebecca L. Gorry, Luisa M. Welp, Sarah Mae Penir, Yehor Horokhovskyi, Shiya Cheng, Katsuyoshi Takaoka, Alexandra Stützer, Ann-Sophie Frombach, Ana Lisa Taylor Tavares, Monika Raabe, Sara Haag, Debojit Saha, Katharina Grewe, Vera Schipper, Silvio O. Rizzoli, Henning Urlaub, Juliane Liepe, Melina Schuh
Publicado en: Nature Cell Biology, Edición 26, 2024, Página(s) 1124-1138, ISSN 1465-7392
Editor: Nature Publishing Group
DOI: 10.1038/s41556-024-01442-7

iBench: A ground truth approach for advanced validation of mass spectrometry identification method

Autores: John A. Cormican, Wai Tuck Soh, Michele Mishto, Juliane Liepe
Publicado en: Proteomics, Edición 16159853, 2022, ISSN 1615-9853
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/pmic.202200271

Protein degradation by human 20S proteasomes elucidates the interplay between peptide hydrolysis and splicing

Autores: Wai Tuck Soh, Hanna P. Roetschke, John A. Cormican, Bei Fang Teo, Nyet Cheng Chiam, Monika Raabe, Ralf Pflanz, Fabian Henneberg, Stefan Becker, Ashwin Chari, Haiyan Liu, Henning Urlaub, Juliane Liepe, Michele Mishto
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-45339-3

Database search engines and target database features impinge upon the identification of post-translationally cis-spliced peptides in HLA class I immunopeptidomes

Autores: Michele Mishto, Yehor Horokhovskyi, John A. Cormican, Xiaoping Yang, Steven Lynham, Henning Urlaub, Juliane Liepe
Publicado en: Proteomics, Edición 16159853, 2022, Página(s) 2100226, ISSN 1615-9853
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/pmic.202100226

Chemical crosslinking extends and complements UV crosslinking in analysis of RNA/DNA nucleic acid–protein interaction sites by mass spectrometry

Autores: Luisa M Welp, Alexander Wulf, Aleksandar Chernev, Yehor Horokhovskyi, Sergei Moshkovskii, Olexandr Dybkov, Piotr Neumann, Martin Pašen, Arslan Siraj, Monika Raabe, Henri Göthert, James L Walshe, Deliana A Infante, Ana C de A.P. Schwarzer, Achim Dickmanns, Sven Johannsson, Jana Schmitzová, Ingo Wohlgemuth, Eugen Netz, Yi He, Kai Fritzemeier, Bernard Delanghe, Rosa Viner, Seychelle M Vos,
Publicado en: Nucleic Acids Research, Edición 53, 2025, ISSN 0305-1048
Editor: Oxford University Press
DOI: 10.1093/nar/gkaf727

An Automated Workflow to Address Proteome Complexity and the Large Search Space Problem in Proteomics and HLA-I Immunopeptidomics

Autores: Yehor Horokhovskyi, Hanna P. Roetschke, John A. Cormican, Martin Pašen, Sina Garazhian, Michele Mishto, Juliane Liepe
Publicado en: Molecular & Cellular Proteomics, Edición 24, 2025, Página(s) 101039, ISSN 1535-9476
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.mcpro.2025.101039

Predicting the success of Fmoc-based peptide synthesis.

Autores: Ilanit Gutman; Ron Gutman; John Sidney; Leila Chihab; Michele Mishto; Juliane Liepe; Anthony Chiem; Jason Greenbaum; Zhen Yan; Alessandro Sette; Zeynep Koşaloğlu-Yalçın; Bjoern Peters
Publicado en: ACS Omega, Edición 24701343, 2022, ISSN 2470-1343
Editor: American Chemical Society
DOI: 10.25418/crick.20376597.v1

A roadmap for ribosome assembly in human mitochondria

Autores: Elena Lavdovskaia, Elisa Hanitsch, Andreas Linden, Martin Pašen, Venkatapathi Challa, Yehor Horokhovskyi, Hanna P. Roetschke, Franziska Nadler, Luisa Welp, Emely Steube, Marleen Heinrichs, Mandy Mong-Quyen Mai, Henning Urlaub, Juliane Liepe, Ricarda Richter-Dennerlein
Publicado en: Nature Structural & Molecular Biology, Edición 31, 2024, Página(s) 1898-1908, ISSN 1545-9993
Editor: Nature Publishing Group
DOI: 10.1038/s41594-024-01356-w

Response: Commentary: An In Silico–In Vitro Pipeline Identifying an HLA-A*02:01+ KRAS G12V+ Spliced Epitope Candidate for a Broad Tumor-Immune Response in Cancer Patients

Autores: Michele Mishto, Guillermo Rodriguez-Hernandez, Jacques Neefjes, Henning Urlaub, Juliane Liepe4*
Publicado en: Frontiers in Immunology, Edición 12, 2021, ISSN 1664-3224
Editor: Lausanne: Frontiers Media S.A., 2010-
DOI: 10.3389/fimmu.2021.679836

Proteasome isoforms in human thymi and mouse models

Autores: Michele Mishto, Iina Takala, Paola Bonfanti, Juliane Liepe
Publicado en: Immunology Letters, Edición 269, 2025, Página(s) 106899, ISSN 0165-2478
Editor: Elsevier BV
DOI: 10.1016/j.imlet.2024.106899

PEPSeek-Mediated Identification of Novel Epitopes From Viral and Bacterial Pathogens and the Impact on Host Cell Immunopeptidomes

Autores: John A. Cormican, Lobna Medfai, Magdalena Wawrzyniuk, Martin Pašen, Hassnae Afrache, Constance Fourny, Sahil Khan, Pascal Gneiße, Wai Tuck Soh, Arianna Timelli, Emanuele Nolfi, Yvonne Pannekoek, Andrew Cope, Henning Urlaub, Alice J.A.M. Sijts, Michele Mishto, Juliane Liepe
Publicado en: Molecular & Cellular Proteomics, Edición 24, 2025, Página(s) 100937, ISSN 1535-9476
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.mcpro.2025.100937

Potential Mimicry of Viral and Pancreatic β Cell Antigens Through Non-Spliced and cis-Spliced Zwitter Epitope Candidates in Type 1 Diabetes

Autores: Michele Mishto, Artem Mansurkhodzhaev, Teresa Rodriguez-Calvo, Juliane Liepe
Publicado en: Front. Immunol., Edición 16643224, 2021, ISSN 1664-3224
Editor: Lausanne: Frontiers Media S.A., 2010-
DOI: 10.3389/fimmu.2021.656451

InvitroSPI and a large database of proteasome-generated spliced and non-spliced peptides

Autores: Hanna P. Roetschke; Guillermo Rodriguez-Hernandez; John A. Cormican; Xiaoping Yang; Steven Lynham; Michele Mishto; Juliane Liepe
Publicado en: Scientific Data, Edición 1, 2023, ISSN 2052-4463
Editor: Nature Publishing Group, 2014-
DOI: 10.1038/s41597-022-01890-6

inSPIRE: An open-source tool for increased mass spectrometry identification rates using Prosit spectral prediction

Autores: John A. Cormican, Yehor Horokhovskyi, Wai Tuck Soh, Michele Mishto, Juliane Liepe
Publicado en: Molecular & Cellular Proteomics, Edición 15359476, 2022, ISSN 1535-9476
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.mcpro.2022.100432