Understanding and targeting the functional consequences of aneuploidy in cancer

Informazioni relative al progetto

CancerAneuploidy

ID dell’accordo di sovvenzione: 945674

DOI

10.3030/945674

Data della firma CE 2 Dicembre 2020

Data di avvio 1 Ottobre 2021

Data di completamento 30 Settembre 2027

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 612 500,00

Contributo UE

€ 1 612 500,00

Coordinato da

TEL AVIV UNIVERSITY
Israel

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (20)

Integrating mutation, copy number, and gene expression data to identify driver genes of recurrent chromosome-arm losses

Autori: Ron Saad, Ron Shamir, Uri Ben-David
Pubblicato in: Cell Reports, Numero 44, 2026, Pagina/e 116455, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2025.116455

Feeder-free culture of human pluripotent stem cells drives MDM4-mediated gain of chromosome 1q

Autori: Dylan Stavish, Christopher J. Price, Gabriele Gelezauskaite, Haneen Alsehli, Kimberly A. Leonhard, Seth M. Taapken, Erik M. McIntire, Owen Laing, Bethany M. James, Jack J. Riley, Johanna Zerbib, Duncan Baker, Amy L. Harding, Lydia H. Jestice, Thomas F. Eleveld, Ad J.M. Gillis, Sanne Hillenius, Leendert H.J. Looijenga, Paul J. Gokhale, Uri Ben-David, Tenneille E. Ludwig, Ivana Barbaric
Pubblicato in: Stem Cell Reports, Numero 19, 2024, Pagina/e 1217-1232, ISSN 2213-6711
Editore: Cell Press
DOI: 10.1016/j.stemcr.2024.06.003

Chromosome 7 Gain Compensates for Chromosome 10 Loss in Glioma

Autori: Nishanth Ulhas Nair, Alejandro A. Schäffer, E. Michael Gertz, Kuoyuan Cheng, Johanna Zerbib, Avinash Das Sahu, Gil Leor, Eldad D. Shulman, Kenneth D. Aldape, Uri Ben-David, Eytan Ruppin
Pubblicato in: Cancer Research, Numero 84, 2024, Pagina/e 3464-3477, ISSN 0008-5472
Editore: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-24-1366

Aneuploidy as a driver of human cancer

Autori: Eran Sdeor, Hajime Okada, Ron Saad, Tal Ben-Yishay, Uri Ben-David
Pubblicato in: Nature Genetics, 2024, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-024-01916-2

FBXW7 E3 ligase prevents centriole overduplication by degrading the Plk4 phosphorylated STIL-SAS6 cartwheel assembly

Autori: Ushma Anand, Amit Bloomberg, Pradip Bhattacharjee, Swarnendu Mukhopadhyay, Binshad Badarudeen, Shivani Ramakrishnan, Uri Ben-David, Tapas K. Manna
Pubblicato in: Journal of Biological Chemistry, Numero 302, 2026, Pagina/e 111104, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2025.111104

CKAP5 stabilizes CENP-E at kinetochores by regulating microtubule-chromosome attachments

Autori: R Bhagya Lakshmi; Pinaki Nayak; Linoy Raz; Apurba Sarkar; Akshay Saroha; Pratibha Kumari; Vishnu M Nair; Delvin P Kombarakkaran; S Sajana; Sanusha M G; Sarit S Agasti; Raja Paul; Uri Ben-David; Tapas K Manna
Pubblicato in: Crossref, Numero 3, 2023, ISSN 1469-3178
Editore: EMBO Press
DOI: 10.1038/s44319-024-00106-9

p53 inactivation drives breast cancer metastasis to the brain through SCD1 upregulation and increased fatty acid metabolism

Autori: Kathrin Laue, Sabina Pozzi, Johanna Zerbib, Rebecca Bertolio, Yonatan Eliezer, Yael Cohen-Sharir, Tom Winkler, Manuel Caputo, Alessia A. Ricci, Lital Adler, Rami Khoury, Giuseppe Longobardi, Rachel Slutsky, Alicia I. Leikin-Frenkel, Shai Ovadia, Katharina Lange, Alessandra Rustighi, Silvano Piazza, Andrea Sacconi, Rayna Y. Magesh, Faith N. Keller, Jean Berthelet, Alexander Schäffer, Ron Saad, Sah
Pubblicato in: Nature Genetics, Numero 58, 2026, Pagina/e 116-131, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-025-02446-1

Increased RNA and Protein Degradation Is Required for Counteracting Transcriptional Burden and Proteotoxic Stress in Human Aneuploid Cells

Autori: Marica Rosaria Ippolito, Johanna Zerbib, Yonatan Eliezer, Eli Reuveni, Sonia Viganò, Giuseppina De Feudis, Eldad D. Shulman, Anouk Savir Kadmon, Rachel Slutsky, Tiangen Chang, Emma M. Campagnolo, Silvia Taglietti, Simone Scorzoni, Sara Gianotti, Sara Martin, Julia Muenzner, Michael Mülleder, Nir Rozenblum, Carmela Rubolino, Tal Ben-Yishay, Kathrin Laue, Yael Cohen-Sharir, Ilaria Vigorito, France
Pubblicato in: Cancer Discovery, 2024, Pagina/e OF1-OF22, ISSN 2159-8274
Editore: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-23-0309

Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage

Autori: Johanna Zerbib, Marica Rosaria Ippolito, Yonatan Eliezer, Giuseppina De Feudis, Eli Reuveni, Anouk Savir Kadmon, Sara Martin, Sonia Viganò, Gil Leor, James Berstler, Julia Muenzner, Michael Mülleder, Emma M. Campagnolo, Eldad D. Shulman, Tiangen Chang, Carmela Rubolino, Kathrin Laue, Yael Cohen-Sharir, Simone Scorzoni, Silvia Taglietti, Alice Ratti, Chani Stossel, Talia Golan, Francesco Nicassio
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-52176-x

Cell and Nuclear Size Is Associated with Chromosomal Instability and Tumorigenicity in Cancer Cells That Undergo Whole Genome Doubling

Autori: Mathew Bloomfield, Sydney M. Huth, Daniella S. McCausland, Ron Saad, Nazia Bano, Tran N. Chau, Megan L. Sweet, Nicolaas C. Baudoin, Andrew McCaffrey, Kai Fluet, Eva M. Schmelz, Uri Ben-David, Daniela Cimini
Pubblicato in: Cancer Research, Numero 86, 2026, Pagina/e 2126-2142, ISSN 0008-5472
Editore: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-24-3718

Evolutionary rescue by aneuploidy in tumors exposed to anticancer drugs

Autori: Remus Stana, Uri Ben-David, Daniel B Weissman, Yoav Ram
Pubblicato in: GENETICS, Numero 230, 2025, ISSN 1943-2631
Editore: Oxford University Press (OUP)
DOI: 10.1093/genetics/iyaf098

DNA-based copy number analysis confirms genomic evolution of PDX models

Autori: Anna C. H. Hoge, Michal Getz, Anat Zimmer, Minjeong Ko, Linoy Raz, Rameen Beroukhim, Todd R. Golub, Gavin Ha & Uri Ben-David
Pubblicato in: npj Precision Oncology, 2022, ISSN 2397-768X
Editore: Springer Nature
DOI: 10.1038/s41698-022-00268-6

Short-term molecular consequences of chromosome mis-segregation for genome stability

Autori: Lorenza Garribba; Giuseppina De Feudis; Valentino Martis; Martina Galli; Marie Dumont; Yonatan Eliezer; René Wardenaar; Marica Rosaria Ippolito; Divya Ramalingam Iyer; Andréa E. Tijhuis; Diana C. J. Spierings; Michael Schubert; Silvia Taglietti; Chiara Soriani; Simon Gemble; Renata Basto; Nick Rhind; Floris Foijer; Uri Ben-David; Daniele Fachinetti; Ylli Doksani; Stefano Santaguida
Pubblicato in: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023), Numero 2, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-37095-7

High CDC20 levels increase sensitivity of cancer cells to MPS1 inhibitors

Autori: Siqi Zheng, Linoy Raz, Lin Zhou, Yael Cohen-Sharir, Ruifang Tian, Marica Rosaria Ippolito, Sara Gianotti, Ron Saad, Rene Wardenaar, Mathilde Broekhuis, Maria Suarez Peredo Rodriguez, Soraya Wobben, Anouk van den Brink, Petra Bakker, Stefano Santaguida, Floris Foijer, Uri Ben-David
Pubblicato in: EMBO Reports, Numero 26, 2026, Pagina/e 1036-1061, ISSN 1469-3178
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s44319-024-00363-8

The cGAS–STING, p38 MAPK, and p53 pathways link genome instability to accelerated cellular senescence in ATM-deficient murine lung fibroblasts

Autori: Majd Haj, Yann Frey, Amit Levon, Avishai Maliah, Tal Ben-Yishay, Rachel Slutsky, Riham Smoom, Yehuda Tzfati, Uri Ben-David, Carmit Levy, Ran Elkon, Yael Ziv, Yosef Shiloh
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 122, 2025, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2419196122

Machine-learning analysis reveals an important role for negative selection in shaping cancer aneuploidy landscapes

Autori: Juman Jubran, Rachel Slutsky, Nir Rozenblum, Lior Rokach, Uri Ben‑David and Esti Yeger‑Lotem
Pubblicato in: Genome Biology, 2024, ISSN 1474-7596
Editore: BioMed Central
DOI: 10.1186/s13059-024-03225-7

A compendium of Amplification-Related Gain Of Sensitivity genes in human cancer

Autori: Veronica Rendo, Michael Schubert, Nicholas Khuu, Maria F. Suarez Peredo Rodriguez, Declan Whyte, Xiao Ling, Anouk van den Brink, Kaimeng Huang, Michelle Swift, Yizhou He, Johanna Zerbib, Ross Smith, Jonne Raaijmakers, Pratiti Bandopadhayay, Lillian M. Guenther, Justin H. Hwang, Amanda Iniguez, Susan Moody, Ji-Heui Seo, Elizabeth H. Stover, Levi Garraway, William C. Hahn, Kimberly Stegmaier, René
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-025-56301-2

Whole-Genome Duplication Shapes the Aneuploidy Landscape of Human Cancers

Autori: Kavya Prasad; Mathew Bloomfield ; Hagai Levi ; Kristina Keuper ; Sara V. Bernhard; Nicolaas C. Baudoin; Gil Leor ; Yonatan Eliezer; Maybelline Giam; Cheng Kit Wong; Giulia Rancati; Zuzana Storchová ; Daniela Cimini ; Uri Ben-David
Pubblicato in: Cancer Research, 2022, ISSN 1538-7445
Editore: AACR
DOI: 10.1158/0008-5472.can-21-2065

A p62-dependent rheostat dictates micronuclei catastrophe and chromosome rearrangements

Autori: Sara Martin, Simone Scorzoni, Sara Cordone, Alice Mazzagatti, Galina V. Beznoussenko, Amanda L. Gunn, Melody Di Bona, Yonatan Eliezer, Gil Leor, Tal Ben-Yishay, Alessia Loffreda, Valeria Cancila, Maria Chiara Rainone, Marica Rosaria Ippolito, Valentino Martis, Fabio Bedin, Massimiliano Garrè, Laura Pontano Vaites, Paolo Vasapolli, Simona Polo, Dario Parazzoli, Claudio Tripodo, Alexander A. Mirono
Pubblicato in: Science, Numero 385, 2024, ISSN 0036-8075
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.adj7446

Frequent aneuploidy in primary human T cells after CRISPR-Cas9 cleavage

Autori: Alessio David Nahmad, Eli Reuveni , Ella Goldschmidt , Tamar Tenne, Meytal Liberman, Miriam Horovitz-Fried, Rami Khosravi, Hila Kobo, Eyal Reinstein, Asaf Madi, Uri Ben-David, Adi Barzel
Pubblicato in: nature biotechnology, 2022, ISSN 1546-1696
Editore: Springer Nature
DOI: 10.1038/s41587-022-01377-0