Understanding and targeting the functional consequences of aneuploidy in cancer

Informacje na temat projektu

CancerAneuploidy

Identyfikator umowy o grant: 945674

DOI

10.3030/945674

Data podpisania przez KE 2 Grudnia 2020

Data rozpoczęcia 1 Października 2021

Data zakończenia 30 Września 2027

Finansowanie w ramach

• EXCELLENT SCIENCE - European Research Council (ERC)

Koszt całkowity

€ 1 612 500,00

Wkład UE

€ 1 612 500,00

Koordynowany przez

TEL AVIV UNIVERSITY
Israel

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Publikacje

Peer reviewed articles (20)

Integrating mutation, copy number, and gene expression data to identify driver genes of recurrent chromosome-arm losses

Autorzy: Ron Saad, Ron Shamir, Uri Ben-David
Opublikowane w: Cell Reports, Numer 44, 2026, Strona(/y) 116455, ISSN 2211-1247
Wydawca: Cell Press
DOI: 10.1016/j.celrep.2025.116455

Feeder-free culture of human pluripotent stem cells drives MDM4-mediated gain of chromosome 1q

Autorzy: Dylan Stavish, Christopher J. Price, Gabriele Gelezauskaite, Haneen Alsehli, Kimberly A. Leonhard, Seth M. Taapken, Erik M. McIntire, Owen Laing, Bethany M. James, Jack J. Riley, Johanna Zerbib, Duncan Baker, Amy L. Harding, Lydia H. Jestice, Thomas F. Eleveld, Ad J.M. Gillis, Sanne Hillenius, Leendert H.J. Looijenga, Paul J. Gokhale, Uri Ben-David, Tenneille E. Ludwig, Ivana Barbaric
Opublikowane w: Stem Cell Reports, Numer 19, 2024, Strona(/y) 1217-1232, ISSN 2213-6711
Wydawca: Cell Press
DOI: 10.1016/j.stemcr.2024.06.003

Chromosome 7 Gain Compensates for Chromosome 10 Loss in Glioma

Autorzy: Nishanth Ulhas Nair, Alejandro A. Schäffer, E. Michael Gertz, Kuoyuan Cheng, Johanna Zerbib, Avinash Das Sahu, Gil Leor, Eldad D. Shulman, Kenneth D. Aldape, Uri Ben-David, Eytan Ruppin
Opublikowane w: Cancer Research, Numer 84, 2024, Strona(/y) 3464-3477, ISSN 0008-5472
Wydawca: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-24-1366

Aneuploidy as a driver of human cancer

Autorzy: Eran Sdeor, Hajime Okada, Ron Saad, Tal Ben-Yishay, Uri Ben-David
Opublikowane w: Nature Genetics, 2024, ISSN 1061-4036
Wydawca: Nature Publishing Group
DOI: 10.1038/s41588-024-01916-2

FBXW7 E3 ligase prevents centriole overduplication by degrading the Plk4 phosphorylated STIL-SAS6 cartwheel assembly

Autorzy: Ushma Anand, Amit Bloomberg, Pradip Bhattacharjee, Swarnendu Mukhopadhyay, Binshad Badarudeen, Shivani Ramakrishnan, Uri Ben-David, Tapas K. Manna
Opublikowane w: Journal of Biological Chemistry, Numer 302, 2026, Strona(/y) 111104, ISSN 0021-9258
Wydawca: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2025.111104

CKAP5 stabilizes CENP-E at kinetochores by regulating microtubule-chromosome attachments

Autorzy: R Bhagya Lakshmi; Pinaki Nayak; Linoy Raz; Apurba Sarkar; Akshay Saroha; Pratibha Kumari; Vishnu M Nair; Delvin P Kombarakkaran; S Sajana; Sanusha M G; Sarit S Agasti; Raja Paul; Uri Ben-David; Tapas K Manna
Opublikowane w: Crossref, Numer 3, 2023, ISSN 1469-3178
Wydawca: EMBO Press
DOI: 10.1038/s44319-024-00106-9

p53 inactivation drives breast cancer metastasis to the brain through SCD1 upregulation and increased fatty acid metabolism

Autorzy: Kathrin Laue, Sabina Pozzi, Johanna Zerbib, Rebecca Bertolio, Yonatan Eliezer, Yael Cohen-Sharir, Tom Winkler, Manuel Caputo, Alessia A. Ricci, Lital Adler, Rami Khoury, Giuseppe Longobardi, Rachel Slutsky, Alicia I. Leikin-Frenkel, Shai Ovadia, Katharina Lange, Alessandra Rustighi, Silvano Piazza, Andrea Sacconi, Rayna Y. Magesh, Faith N. Keller, Jean Berthelet, Alexander Schäffer, Ron Saad, Sah
Opublikowane w: Nature Genetics, Numer 58, 2026, Strona(/y) 116-131, ISSN 1061-4036
Wydawca: Nature Publishing Group
DOI: 10.1038/s41588-025-02446-1

Increased RNA and Protein Degradation Is Required for Counteracting Transcriptional Burden and Proteotoxic Stress in Human Aneuploid Cells

Autorzy: Marica Rosaria Ippolito, Johanna Zerbib, Yonatan Eliezer, Eli Reuveni, Sonia Viganò, Giuseppina De Feudis, Eldad D. Shulman, Anouk Savir Kadmon, Rachel Slutsky, Tiangen Chang, Emma M. Campagnolo, Silvia Taglietti, Simone Scorzoni, Sara Gianotti, Sara Martin, Julia Muenzner, Michael Mülleder, Nir Rozenblum, Carmela Rubolino, Tal Ben-Yishay, Kathrin Laue, Yael Cohen-Sharir, Ilaria Vigorito, France
Opublikowane w: Cancer Discovery, 2024, Strona(/y) OF1-OF22, ISSN 2159-8274
Wydawca: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-23-0309

Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage

Autorzy: Johanna Zerbib, Marica Rosaria Ippolito, Yonatan Eliezer, Giuseppina De Feudis, Eli Reuveni, Anouk Savir Kadmon, Sara Martin, Sonia Viganò, Gil Leor, James Berstler, Julia Muenzner, Michael Mülleder, Emma M. Campagnolo, Eldad D. Shulman, Tiangen Chang, Carmela Rubolino, Kathrin Laue, Yael Cohen-Sharir, Simone Scorzoni, Silvia Taglietti, Alice Ratti, Chani Stossel, Talia Golan, Francesco Nicassio
Opublikowane w: Nature Communications, Numer 15, 2024, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-024-52176-x

Cell and Nuclear Size Is Associated with Chromosomal Instability and Tumorigenicity in Cancer Cells That Undergo Whole Genome Doubling

Autorzy: Mathew Bloomfield, Sydney M. Huth, Daniella S. McCausland, Ron Saad, Nazia Bano, Tran N. Chau, Megan L. Sweet, Nicolaas C. Baudoin, Andrew McCaffrey, Kai Fluet, Eva M. Schmelz, Uri Ben-David, Daniela Cimini
Opublikowane w: Cancer Research, Numer 86, 2026, Strona(/y) 2126-2142, ISSN 0008-5472
Wydawca: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-24-3718

Evolutionary rescue by aneuploidy in tumors exposed to anticancer drugs

Autorzy: Remus Stana, Uri Ben-David, Daniel B Weissman, Yoav Ram
Opublikowane w: GENETICS, Numer 230, 2025, ISSN 1943-2631
Wydawca: Oxford University Press (OUP)
DOI: 10.1093/genetics/iyaf098

DNA-based copy number analysis confirms genomic evolution of PDX models

Autorzy: Anna C. H. Hoge, Michal Getz, Anat Zimmer, Minjeong Ko, Linoy Raz, Rameen Beroukhim, Todd R. Golub, Gavin Ha & Uri Ben-David
Opublikowane w: npj Precision Oncology, 2022, ISSN 2397-768X
Wydawca: Springer Nature
DOI: 10.1038/s41698-022-00268-6

Short-term molecular consequences of chromosome mis-segregation for genome stability

Autorzy: Lorenza Garribba; Giuseppina De Feudis; Valentino Martis; Martina Galli; Marie Dumont; Yonatan Eliezer; René Wardenaar; Marica Rosaria Ippolito; Divya Ramalingam Iyer; Andréa E. Tijhuis; Diana C. J. Spierings; Michael Schubert; Silvia Taglietti; Chiara Soriani; Simon Gemble; Renata Basto; Nick Rhind; Floris Foijer; Uri Ben-David; Daniele Fachinetti; Ylli Doksani; Stefano Santaguida
Opublikowane w: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023), Numer 2, 2023, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-023-37095-7

High CDC20 levels increase sensitivity of cancer cells to MPS1 inhibitors

Autorzy: Siqi Zheng, Linoy Raz, Lin Zhou, Yael Cohen-Sharir, Ruifang Tian, Marica Rosaria Ippolito, Sara Gianotti, Ron Saad, Rene Wardenaar, Mathilde Broekhuis, Maria Suarez Peredo Rodriguez, Soraya Wobben, Anouk van den Brink, Petra Bakker, Stefano Santaguida, Floris Foijer, Uri Ben-David
Opublikowane w: EMBO Reports, Numer 26, 2026, Strona(/y) 1036-1061, ISSN 1469-3178
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/s44319-024-00363-8

The cGAS–STING, p38 MAPK, and p53 pathways link genome instability to accelerated cellular senescence in ATM-deficient murine lung fibroblasts

Autorzy: Majd Haj, Yann Frey, Amit Levon, Avishai Maliah, Tal Ben-Yishay, Rachel Slutsky, Riham Smoom, Yehuda Tzfati, Uri Ben-David, Carmit Levy, Ran Elkon, Yael Ziv, Yosef Shiloh
Opublikowane w: Proceedings of the National Academy of Sciences, Numer 122, 2025, ISSN 0027-8424
Wydawca: National Academy of Sciences
DOI: 10.1073/pnas.2419196122

Machine-learning analysis reveals an important role for negative selection in shaping cancer aneuploidy landscapes

Autorzy: Juman Jubran, Rachel Slutsky, Nir Rozenblum, Lior Rokach, Uri Ben‑David and Esti Yeger‑Lotem
Opublikowane w: Genome Biology, 2024, ISSN 1474-7596
Wydawca: BioMed Central
DOI: 10.1186/s13059-024-03225-7

A compendium of Amplification-Related Gain Of Sensitivity genes in human cancer

Autorzy: Veronica Rendo, Michael Schubert, Nicholas Khuu, Maria F. Suarez Peredo Rodriguez, Declan Whyte, Xiao Ling, Anouk van den Brink, Kaimeng Huang, Michelle Swift, Yizhou He, Johanna Zerbib, Ross Smith, Jonne Raaijmakers, Pratiti Bandopadhayay, Lillian M. Guenther, Justin H. Hwang, Amanda Iniguez, Susan Moody, Ji-Heui Seo, Elizabeth H. Stover, Levi Garraway, William C. Hahn, Kimberly Stegmaier, René
Opublikowane w: Nature Communications, Numer 16, 2025, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-025-56301-2

Whole-Genome Duplication Shapes the Aneuploidy Landscape of Human Cancers

Autorzy: Kavya Prasad; Mathew Bloomfield ; Hagai Levi ; Kristina Keuper ; Sara V. Bernhard; Nicolaas C. Baudoin; Gil Leor ; Yonatan Eliezer; Maybelline Giam; Cheng Kit Wong; Giulia Rancati; Zuzana Storchová ; Daniela Cimini ; Uri Ben-David
Opublikowane w: Cancer Research, 2022, ISSN 1538-7445
Wydawca: AACR
DOI: 10.1158/0008-5472.can-21-2065

A p62-dependent rheostat dictates micronuclei catastrophe and chromosome rearrangements

Autorzy: Sara Martin, Simone Scorzoni, Sara Cordone, Alice Mazzagatti, Galina V. Beznoussenko, Amanda L. Gunn, Melody Di Bona, Yonatan Eliezer, Gil Leor, Tal Ben-Yishay, Alessia Loffreda, Valeria Cancila, Maria Chiara Rainone, Marica Rosaria Ippolito, Valentino Martis, Fabio Bedin, Massimiliano Garrè, Laura Pontano Vaites, Paolo Vasapolli, Simona Polo, Dario Parazzoli, Claudio Tripodo, Alexander A. Mirono
Opublikowane w: Science, Numer 385, 2024, ISSN 0036-8075
Wydawca: American Association for the Advancement of Science
DOI: 10.1126/science.adj7446

Frequent aneuploidy in primary human T cells after CRISPR-Cas9 cleavage

Autorzy: Alessio David Nahmad, Eli Reuveni , Ella Goldschmidt , Tamar Tenne, Meytal Liberman, Miriam Horovitz-Fried, Rami Khosravi, Hila Kobo, Eyal Reinstein, Asaf Madi, Uri Ben-David, Adi Barzel
Opublikowane w: nature biotechnology, 2022, ISSN 1546-1696
Wydawca: Springer Nature
DOI: 10.1038/s41587-022-01377-0