Understanding and targeting the functional consequences of aneuploidy in cancer

Información del proyecto

CancerAneuploidy

Identificador del acuerdo de subvención: 945674

DOI

10.3030/945674

Fecha de la firma de la CE 2 Diciembre 2020

Fecha de inicio 1 Octubre 2021

Fecha de finalización 30 Septiembre 2027

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 612 500,00

Aportación de la UE

€ 1 612 500,00

Coordinado por

TEL AVIV UNIVERSITY
Israel

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (20)

Integrating mutation, copy number, and gene expression data to identify driver genes of recurrent chromosome-arm losses

Autores: Ron Saad, Ron Shamir, Uri Ben-David
Publicado en: Cell Reports, Edición 44, 2026, Página(s) 116455, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2025.116455

Feeder-free culture of human pluripotent stem cells drives MDM4-mediated gain of chromosome 1q

Autores: Dylan Stavish, Christopher J. Price, Gabriele Gelezauskaite, Haneen Alsehli, Kimberly A. Leonhard, Seth M. Taapken, Erik M. McIntire, Owen Laing, Bethany M. James, Jack J. Riley, Johanna Zerbib, Duncan Baker, Amy L. Harding, Lydia H. Jestice, Thomas F. Eleveld, Ad J.M. Gillis, Sanne Hillenius, Leendert H.J. Looijenga, Paul J. Gokhale, Uri Ben-David, Tenneille E. Ludwig, Ivana Barbaric
Publicado en: Stem Cell Reports, Edición 19, 2024, Página(s) 1217-1232, ISSN 2213-6711
Editor: Cell Press
DOI: 10.1016/j.stemcr.2024.06.003

Chromosome 7 Gain Compensates for Chromosome 10 Loss in Glioma

Autores: Nishanth Ulhas Nair, Alejandro A. Schäffer, E. Michael Gertz, Kuoyuan Cheng, Johanna Zerbib, Avinash Das Sahu, Gil Leor, Eldad D. Shulman, Kenneth D. Aldape, Uri Ben-David, Eytan Ruppin
Publicado en: Cancer Research, Edición 84, 2024, Página(s) 3464-3477, ISSN 0008-5472
Editor: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-24-1366

Aneuploidy as a driver of human cancer

Autores: Eran Sdeor, Hajime Okada, Ron Saad, Tal Ben-Yishay, Uri Ben-David
Publicado en: Nature Genetics, 2024, ISSN 1061-4036
Editor: Nature Publishing Group
DOI: 10.1038/s41588-024-01916-2

FBXW7 E3 ligase prevents centriole overduplication by degrading the Plk4 phosphorylated STIL-SAS6 cartwheel assembly

Autores: Ushma Anand, Amit Bloomberg, Pradip Bhattacharjee, Swarnendu Mukhopadhyay, Binshad Badarudeen, Shivani Ramakrishnan, Uri Ben-David, Tapas K. Manna
Publicado en: Journal of Biological Chemistry, Edición 302, 2026, Página(s) 111104, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2025.111104

CKAP5 stabilizes CENP-E at kinetochores by regulating microtubule-chromosome attachments

Autores: R Bhagya Lakshmi; Pinaki Nayak; Linoy Raz; Apurba Sarkar; Akshay Saroha; Pratibha Kumari; Vishnu M Nair; Delvin P Kombarakkaran; S Sajana; Sanusha M G; Sarit S Agasti; Raja Paul; Uri Ben-David; Tapas K Manna
Publicado en: Crossref, Edición 3, 2023, ISSN 1469-3178
Editor: EMBO Press
DOI: 10.1038/s44319-024-00106-9

p53 inactivation drives breast cancer metastasis to the brain through SCD1 upregulation and increased fatty acid metabolism

Autores: Kathrin Laue, Sabina Pozzi, Johanna Zerbib, Rebecca Bertolio, Yonatan Eliezer, Yael Cohen-Sharir, Tom Winkler, Manuel Caputo, Alessia A. Ricci, Lital Adler, Rami Khoury, Giuseppe Longobardi, Rachel Slutsky, Alicia I. Leikin-Frenkel, Shai Ovadia, Katharina Lange, Alessandra Rustighi, Silvano Piazza, Andrea Sacconi, Rayna Y. Magesh, Faith N. Keller, Jean Berthelet, Alexander Schäffer, Ron Saad, Sah
Publicado en: Nature Genetics, Edición 58, 2026, Página(s) 116-131, ISSN 1061-4036
Editor: Nature Publishing Group
DOI: 10.1038/s41588-025-02446-1

Increased RNA and Protein Degradation Is Required for Counteracting Transcriptional Burden and Proteotoxic Stress in Human Aneuploid Cells

Autores: Marica Rosaria Ippolito, Johanna Zerbib, Yonatan Eliezer, Eli Reuveni, Sonia Viganò, Giuseppina De Feudis, Eldad D. Shulman, Anouk Savir Kadmon, Rachel Slutsky, Tiangen Chang, Emma M. Campagnolo, Silvia Taglietti, Simone Scorzoni, Sara Gianotti, Sara Martin, Julia Muenzner, Michael Mülleder, Nir Rozenblum, Carmela Rubolino, Tal Ben-Yishay, Kathrin Laue, Yael Cohen-Sharir, Ilaria Vigorito, France
Publicado en: Cancer Discovery, 2024, Página(s) OF1-OF22, ISSN 2159-8274
Editor: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-23-0309

Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage

Autores: Johanna Zerbib, Marica Rosaria Ippolito, Yonatan Eliezer, Giuseppina De Feudis, Eli Reuveni, Anouk Savir Kadmon, Sara Martin, Sonia Viganò, Gil Leor, James Berstler, Julia Muenzner, Michael Mülleder, Emma M. Campagnolo, Eldad D. Shulman, Tiangen Chang, Carmela Rubolino, Kathrin Laue, Yael Cohen-Sharir, Simone Scorzoni, Silvia Taglietti, Alice Ratti, Chani Stossel, Talia Golan, Francesco Nicassio
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-52176-x

Cell and Nuclear Size Is Associated with Chromosomal Instability and Tumorigenicity in Cancer Cells That Undergo Whole Genome Doubling

Autores: Mathew Bloomfield, Sydney M. Huth, Daniella S. McCausland, Ron Saad, Nazia Bano, Tran N. Chau, Megan L. Sweet, Nicolaas C. Baudoin, Andrew McCaffrey, Kai Fluet, Eva M. Schmelz, Uri Ben-David, Daniela Cimini
Publicado en: Cancer Research, Edición 86, 2026, Página(s) 2126-2142, ISSN 0008-5472
Editor: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-24-3718

Evolutionary rescue by aneuploidy in tumors exposed to anticancer drugs

Autores: Remus Stana, Uri Ben-David, Daniel B Weissman, Yoav Ram
Publicado en: GENETICS, Edición 230, 2025, ISSN 1943-2631
Editor: Oxford University Press (OUP)
DOI: 10.1093/genetics/iyaf098

DNA-based copy number analysis confirms genomic evolution of PDX models

Autores: Anna C. H. Hoge, Michal Getz, Anat Zimmer, Minjeong Ko, Linoy Raz, Rameen Beroukhim, Todd R. Golub, Gavin Ha & Uri Ben-David
Publicado en: npj Precision Oncology, 2022, ISSN 2397-768X
Editor: Springer Nature
DOI: 10.1038/s41698-022-00268-6

Short-term molecular consequences of chromosome mis-segregation for genome stability

Autores: Lorenza Garribba; Giuseppina De Feudis; Valentino Martis; Martina Galli; Marie Dumont; Yonatan Eliezer; René Wardenaar; Marica Rosaria Ippolito; Divya Ramalingam Iyer; Andréa E. Tijhuis; Diana C. J. Spierings; Michael Schubert; Silvia Taglietti; Chiara Soriani; Simon Gemble; Renata Basto; Nick Rhind; Floris Foijer; Uri Ben-David; Daniele Fachinetti; Ylli Doksani; Stefano Santaguida
Publicado en: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023), Edición 2, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-37095-7

High CDC20 levels increase sensitivity of cancer cells to MPS1 inhibitors

Autores: Siqi Zheng, Linoy Raz, Lin Zhou, Yael Cohen-Sharir, Ruifang Tian, Marica Rosaria Ippolito, Sara Gianotti, Ron Saad, Rene Wardenaar, Mathilde Broekhuis, Maria Suarez Peredo Rodriguez, Soraya Wobben, Anouk van den Brink, Petra Bakker, Stefano Santaguida, Floris Foijer, Uri Ben-David
Publicado en: EMBO Reports, Edición 26, 2026, Página(s) 1036-1061, ISSN 1469-3178
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s44319-024-00363-8

The cGAS–STING, p38 MAPK, and p53 pathways link genome instability to accelerated cellular senescence in ATM-deficient murine lung fibroblasts

Autores: Majd Haj, Yann Frey, Amit Levon, Avishai Maliah, Tal Ben-Yishay, Rachel Slutsky, Riham Smoom, Yehuda Tzfati, Uri Ben-David, Carmit Levy, Ran Elkon, Yael Ziv, Yosef Shiloh
Publicado en: Proceedings of the National Academy of Sciences, Edición 122, 2025, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2419196122

Machine-learning analysis reveals an important role for negative selection in shaping cancer aneuploidy landscapes

Autores: Juman Jubran, Rachel Slutsky, Nir Rozenblum, Lior Rokach, Uri Ben‑David and Esti Yeger‑Lotem
Publicado en: Genome Biology, 2024, ISSN 1474-7596
Editor: BioMed Central
DOI: 10.1186/s13059-024-03225-7

A compendium of Amplification-Related Gain Of Sensitivity genes in human cancer

Autores: Veronica Rendo, Michael Schubert, Nicholas Khuu, Maria F. Suarez Peredo Rodriguez, Declan Whyte, Xiao Ling, Anouk van den Brink, Kaimeng Huang, Michelle Swift, Yizhou He, Johanna Zerbib, Ross Smith, Jonne Raaijmakers, Pratiti Bandopadhayay, Lillian M. Guenther, Justin H. Hwang, Amanda Iniguez, Susan Moody, Ji-Heui Seo, Elizabeth H. Stover, Levi Garraway, William C. Hahn, Kimberly Stegmaier, René
Publicado en: Nature Communications, Edición 16, 2025, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-025-56301-2

Whole-Genome Duplication Shapes the Aneuploidy Landscape of Human Cancers

Autores: Kavya Prasad; Mathew Bloomfield ; Hagai Levi ; Kristina Keuper ; Sara V. Bernhard; Nicolaas C. Baudoin; Gil Leor ; Yonatan Eliezer; Maybelline Giam; Cheng Kit Wong; Giulia Rancati; Zuzana Storchová ; Daniela Cimini ; Uri Ben-David
Publicado en: Cancer Research, 2022, ISSN 1538-7445
Editor: AACR
DOI: 10.1158/0008-5472.can-21-2065

A p62-dependent rheostat dictates micronuclei catastrophe and chromosome rearrangements

Autores: Sara Martin, Simone Scorzoni, Sara Cordone, Alice Mazzagatti, Galina V. Beznoussenko, Amanda L. Gunn, Melody Di Bona, Yonatan Eliezer, Gil Leor, Tal Ben-Yishay, Alessia Loffreda, Valeria Cancila, Maria Chiara Rainone, Marica Rosaria Ippolito, Valentino Martis, Fabio Bedin, Massimiliano Garrè, Laura Pontano Vaites, Paolo Vasapolli, Simona Polo, Dario Parazzoli, Claudio Tripodo, Alexander A. Mirono
Publicado en: Science, Edición 385, 2024, ISSN 0036-8075
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.adj7446

Frequent aneuploidy in primary human T cells after CRISPR-Cas9 cleavage

Autores: Alessio David Nahmad, Eli Reuveni , Ella Goldschmidt , Tamar Tenne, Meytal Liberman, Miriam Horovitz-Fried, Rami Khosravi, Hila Kobo, Eyal Reinstein, Asaf Madi, Uri Ben-David, Adi Barzel
Publicado en: nature biotechnology, 2022, ISSN 1546-1696
Editor: Springer Nature
DOI: 10.1038/s41587-022-01377-0