Cross-omics integration to identify modulators for improving vaccine efficacy

Project Information

ModVaccine

Grant agreement ID: 948207

DOI

10.3030/948207

EC signature date 14 December 2020

Start date 1 January 2021

End date 31 December 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 499 871,00

EU contribution

€ 1 499 871,00

Coordinated by

HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (21)

Immune memory in individuals with COVID-19

Author(s): Netea M.G., Li Y.
Published in: Nature Cell Biology, 2021, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-021-00689-8

Tan, I. L., Coutinho de Almeida, R., Modderman, R., Stachurska, A., Dekens, J., Barisani, D., Meijer, C. R., Roca, M., Martinez-Ojinaga, E., Shamir, R., Auricchio, R., Korponay-Szabó, I. R., Castillejo, G., Szajewska, H., Koletzko, S., Zhernakova, A., Kumar, V., Li, Y., Visschedijk, M. C., Weersma, R. K., Withoff, S.

Author(s): Circulating miRNAs as Potential Biomarkers for Celiac Disease Development.
Published in: Frontiers in immunology, 2021, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2021.734763

Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment

Author(s): Schulte-Schrepping J, Reusch N, Paclik D, Baßler K, Schlickeiser S, Zhang B, Krämer B, Krammer T, Brumhard S, Bonaguro L, De Domenico E, Wendisch D, Grasshoff M, Kapellos TS, Beckstette M, Pecht T, Saglam A, Dietrich O, Mei HE, Schulz AR, Conrad C, Kunkel D, Vafadarnejad E, Xu CJ, Horne A, Herbert M, Drews A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, Müller-Redetzky H, Heim KM, Machleidt
Published in: Cell, 2020, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.08.001

Multi-Omics Integration Reveals Only Minor Long-Term Molecular and Functional Sequelae in Immune Cells of Individuals Recovered From COVID-19

Author(s): Liu, Z., Kilic, G., Li, W., Bulut, O., Gupta, M.K., Zhang, B., Qi, C., Peng, H., Tsay, H.-C., Soon, C. F., Mekonnen, Y.A., van der Made, C. I., van Cranenbroek, B., Koenen, H. J. P. M., Simonetti, E., Diavatopoulos, D., de Jonge, M. I., Müller, L., Schaal, H., Ostermann, P. N., Cornberg, M., Eiz-Vesper, B., van de Veerdonk, F., van Crevel, R., Joosten, L A. B., Domínguez-Andrés, J., Xu, C.-J.,
Published in: Frontiers in Immunology, 2022, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.838132

A single-cell view on host immune transcriptional response to in vivo BCG-induced trained immunity

Author(s): Li, W., Moorlag, S., Koeken, V.C.A.M., Röring, R.J., L de Bree, C., Mourits, V.P., Gupta, M.K., Zhang, B., Fu, J., Zhang, Z., Grondman, I., van Meijgaarden, K.E., Zhou, L., Alaswad, A., Joosten, L.A.B., van Crevel, R., Xu, C.-J., Netea, M.G., Li, Y.
Published in: Cell reports, 2023, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2023.112487

Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease

Author(s): Xiaojing Chu; Xiaojing Chu; Martin Jaeger; Joep Beumer; Olivier B. Bakker; Raul Aguirre-Gamboa; Marije Oosting; Sanne P. Smeekens; Simone J.C.F.M. Moorlag; Vera P. Mourits; Valerie A. C. M. Koeken; Valerie A. C. M. Koeken; Charlotte de Bree; Trees Jansen; Ian T. Mathews; Ian T. Mathews; Khoi Dao; Mahan Najhawan; Jeramie D. Watrous; Irma Joosten; Sonia Sharma; Hans J. P. M. Koenen; Sebo Withoff; Ir
Published in: Genome Biology, Issue 3, 2021, ISSN 1474-760X
Publisher: BioMed Central
DOI: 10.1186/s13059-021-02413-z

Differences in Immune Responses in Individuals of Indian and European Origin: Relevance for the COVID-19 Pandemic

Author(s): Geckin, B., Zoodsma, M., Kilic, G., Debisarun, P.A., Rakshit, S., Adiga, V., Ahmed, A., Parthiban, C., Chetan Kumar, N., D’Souza, G., Baltissen, M.P., Martens, J.H.A., Domínguez-Andrés, J., Li, Y., Vyakarnam, A., Netea, M.G
Published in: Microbiology Spectrum, 2023, ISSN 2165-0497
Publisher: American Society for Microbiology
DOI: 10.1128/spectrum.00231-23

IRF7 and RNH1 are modifying factors of HIV-1 reservoirs: a genome-wide association analysis.

Author(s): Zhenhua Zhang; Wim Trypsteen; Marc Blaauw; Xiaojing Chu; Xiaojing Chu; Sofie Rutsaert; Linos Vandekerckhove; Wouter A. van der Heijden; Jéssica Cristina dos Santos; Cheng-Jian Xu; Morris A. Swertz; André J. A. M. van der Ven; Yang Li
Published in: BMC Medicine, Issue 3, 2021, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-021-02156-5

Multi-Omics Approaches in Immunological Research

Author(s): Chu, X., Zhang, B., Koeken, V., Gupta, M.K., Li, Y.
Published in: Frontiers in immunology, 2022, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2021.668045

Evolutionary Trajectories of Complex Traits in European Populations of Modern Humans

Author(s): Yunus Kuijpers; Jorge Domínguez-Andrés; Olivier B. Bakker; Manoj Kumar Gupta; Martin Grasshoff; Cheng-Jian Xu; Leo A.B. Joosten; Jaume Bertranpetit; Mihai G. Netea; Yang Li
Published in: Frontiers in Genetics, Issue 3, 2022, ISSN 1664-8021
Publisher: Frontiers Media
DOI: 10.3389/fgene.2022.833190

Plasma metabolome predicts trained immunity responses after antituberculosis BCG vaccination

Author(s): Koeken, V.A.C.M., Qi, C., Mourits, V.P., de Bree, L.C.J., Moorlag, S.J.C.F.M., Sonawane, V., Heidi Lemmers, Dijkstra, H., Joosten, L.A.B., van Laarhoven, A., Xu, C.-J., van Crevel, R., Netea, M.G., Li, Y
Published in: PLoS Biology, 2022, ISSN 1544-9173
Publisher: Public Library of Science
DOI: 10.1371/journal.pbio.3001765

The role of DNA methylation in personalized medicine for immune-related diseases

Author(s): Gupta, M.K., Peng, H., Li, Y., Xu, C.-J.
Published in: Pharmacology & Therapeutics, 2023, ISSN 0163-7258
Publisher: Pergamon Press
DOI: 10.1016/j.pharmthera.2023.108508

The Genetic Risk for COVID-19 Severity Is Associated With Defective Immune Responses

Author(s): Kuijpers, Y., Chu, X., Jaeger, M., Moorlag, S.J.C.F.M., Koeken, V.A.C.M., Zhang, B., de Nooijer, A., Grondman, I., Gupta, M.K., Janssen, N., Mourits, V.P., de Bree, L.C.J., de Mast, Q., van de Veerdonk, F.L., Joosten, L.A.B., L,i Y., Netea, M.G., Xu, C.J.
Published in: Frontiers in Immunology, 2022, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.859387

Evolution of cytokine production capacity in ancient and modern European populations

Author(s): Jorge Domínguez-Andrés; Yunus Kuijpers; Olivier B. Bakker; Martin Jaeger; Cheng-Jian Xu; Cheng-Jian Xu; Jos W. M. van der Meer; Mattias Jakobsson; Mattias Jakobsson; Jaume Bertranpetit; Leo A. B. Joosten; Yang Li; Mihai G. Netea; Mihai G. Netea
Published in: eLife, Issue 4, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.1101/2021.01.14.426690

Resolving trained immunity with systems biology

Author(s): Valerie A. C. M. Koeken; Valerie A. C. M. Koeken; Reinout van Crevel; Mihai G. Netea; Mihai G. Netea; Yang Li; Yang Li
Published in: European Journal of Immunology, Issue 3, 2021, ISSN 0014-2980
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202048882

A genome-wide functional genomics approach uncovers genetic determinants of immune phenotypes in type 1 diabetes

Author(s): "Chu, X., Janssen, A.W.M., Koenen, H., Chang, L., He, X., Joosten, I., Stienstra, R., Kuijpers, Y., Wijmenga, C., Xu, C.- J., Netea, M.G, Tack, C.J., Li, Y.#"
Published in: eLife, 2022, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.73709

Single-cell RNA sequencing reveals induction of distinct trained immunity programs in human monocytes.

Author(s): "Zhang, B., Moorlag, S., Domínguez-Andrés, J., Bulut, Ö., Kilic, G., Liu, Z., van Crevel, R., Xu,C.-J., Joosten, L.A.B., Netea, M.G.#, Li, Y.#"
Published in: Journal of Clinical investigation, 2022, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci147719

Single-Cell RNA Sequencing of Peripheral Blood Mononuclear Cells From Pediatric Coeliac Disease Patients Suggests Potential Pre-Seroconversion Markers

Author(s): Aarón D. Ramírez-Sánchez; Xiaojing Chu; Rutger Modderman; Yvonne Kooy-Winkelaar; Sibylle Koletzko; Ilma R. Korponay-Szabó; Riccardo Troncone; Cisca Wijmenga; Luisa Mearin; Sebo Withoff; Iris H. Jonkers; Yang Li
Published in: Frontiers in Immunology, Issue 2, 2022, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.843086

Induction of trained immunity by influenza vaccination - impact on COVID-19.

Author(s): Priya A. Debisarun; Katharina L. Gössling; Ozlem Bulut; Gizem Kilic; Martijn Zoodsma; Zhaoli Liu; Marina Oldenburg; Nadine Rüchel; Bowen Zhang; Cheng-Jian Xu; Cheng-Jian Xu; Patrick Struycken; Valerie A. C. M. Koeken; Valerie A. C. M. Koeken; Jorge Domínguez-Andrés; Simone J.C.F.M. Moorlag; Esther Taks; Philipp Niklas Ostermann; Lisa Müller; Heiner Schaal; Ortwin Adams; Arndt Borkhardt; Jaap
Published in: Plos Pathogens, Issue 3, 2021, ISSN 1553-7366
Publisher: Public Library of Science
DOI: 10.1371/journal.ppat.1009928

Altered and allele-specific open chromatin landscape reveals epigenetic and genetic regulators of innate immunity in COVID-19

Author(s): Zhang, B., Zhang, Z., Koeken, V.A.C.M., Kumar, S., Aillaud, M., Tsay, H.-C., Liu, Z., Kraft, A.R.M., Soon, C.F., Odak, I., Bošnjak, B., Vlot, A., Deutsche COVID-19 OMICS Initiative (DeCOI), Swertz, M.A., Ohler, U., Geffers, R., Illig, T., Huehn, J., Saliba, A.E., Sander, L.E., Förster, R., Xu, C.-J., Cornberg, M., Schulte, L.N., Li, Y
Published in: Cell Genomics, 2023, ISSN 2666-979X
Publisher: Elsevier
DOI: 10.1016/j.xgen.2022.100232

Metabolomics meets systems immunology

Author(s): Fu, J., Zhu, F., Xu, C.-J., Li, Y
Published in: EMBO Reports, 2023, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.202255747