Cross-omics integration to identify modulators for improving vaccine efficacy

Informazioni relative al progetto

ModVaccine

ID dell’accordo di sovvenzione: 948207

DOI

10.3030/948207

Data della firma CE 14 Dicembre 2020

Data di avvio 1 Gennaio 2021

Data di completamento 31 Dicembre 2025

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 1 499 871,00

Contributo UE

€ 1 499 871,00

Coordinato da

HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (21)

Immune memory in individuals with COVID-19

Autori: Netea M.G., Li Y.
Pubblicato in: Nature Cell Biology, 2021, ISSN 1465-7392
Editore: Nature Publishing Group
DOI: 10.1038/s41556-021-00689-8

Tan, I. L., Coutinho de Almeida, R., Modderman, R., Stachurska, A., Dekens, J., Barisani, D., Meijer, C. R., Roca, M., Martinez-Ojinaga, E., Shamir, R., Auricchio, R., Korponay-Szabó, I. R., Castillejo, G., Szajewska, H., Koletzko, S., Zhernakova, A., Kumar, V., Li, Y., Visschedijk, M. C., Weersma, R. K., Withoff, S.

Autori: Circulating miRNAs as Potential Biomarkers for Celiac Disease Development.
Pubblicato in: Frontiers in immunology, 2021, ISSN 1664-3224
Editore: Frontiers Media S.A.
DOI: 10.3389/fimmu.2021.734763

Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment

Autori: Schulte-Schrepping J, Reusch N, Paclik D, Baßler K, Schlickeiser S, Zhang B, Krämer B, Krammer T, Brumhard S, Bonaguro L, De Domenico E, Wendisch D, Grasshoff M, Kapellos TS, Beckstette M, Pecht T, Saglam A, Dietrich O, Mei HE, Schulz AR, Conrad C, Kunkel D, Vafadarnejad E, Xu CJ, Horne A, Herbert M, Drews A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, Müller-Redetzky H, Heim KM, Machleidt
Pubblicato in: Cell, 2020, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2020.08.001

Multi-Omics Integration Reveals Only Minor Long-Term Molecular and Functional Sequelae in Immune Cells of Individuals Recovered From COVID-19

Autori: Liu, Z., Kilic, G., Li, W., Bulut, O., Gupta, M.K., Zhang, B., Qi, C., Peng, H., Tsay, H.-C., Soon, C. F., Mekonnen, Y.A., van der Made, C. I., van Cranenbroek, B., Koenen, H. J. P. M., Simonetti, E., Diavatopoulos, D., de Jonge, M. I., Müller, L., Schaal, H., Ostermann, P. N., Cornberg, M., Eiz-Vesper, B., van de Veerdonk, F., van Crevel, R., Joosten, L A. B., Domínguez-Andrés, J., Xu, C.-J.,
Pubblicato in: Frontiers in Immunology, 2022, ISSN 1664-3224
Editore: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.838132

A single-cell view on host immune transcriptional response to in vivo BCG-induced trained immunity

Autori: Li, W., Moorlag, S., Koeken, V.C.A.M., Röring, R.J., L de Bree, C., Mourits, V.P., Gupta, M.K., Zhang, B., Fu, J., Zhang, Z., Grondman, I., van Meijgaarden, K.E., Zhou, L., Alaswad, A., Joosten, L.A.B., van Crevel, R., Xu, C.-J., Netea, M.G., Li, Y.
Pubblicato in: Cell reports, 2023, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2023.112487

Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease

Autori: Xiaojing Chu; Xiaojing Chu; Martin Jaeger; Joep Beumer; Olivier B. Bakker; Raul Aguirre-Gamboa; Marije Oosting; Sanne P. Smeekens; Simone J.C.F.M. Moorlag; Vera P. Mourits; Valerie A. C. M. Koeken; Valerie A. C. M. Koeken; Charlotte de Bree; Trees Jansen; Ian T. Mathews; Ian T. Mathews; Khoi Dao; Mahan Najhawan; Jeramie D. Watrous; Irma Joosten; Sonia Sharma; Hans J. P. M. Koenen; Sebo Withoff; Ir
Pubblicato in: Genome Biology, Numero 3, 2021, ISSN 1474-760X
Editore: BioMed Central
DOI: 10.1186/s13059-021-02413-z

Differences in Immune Responses in Individuals of Indian and European Origin: Relevance for the COVID-19 Pandemic

Autori: Geckin, B., Zoodsma, M., Kilic, G., Debisarun, P.A., Rakshit, S., Adiga, V., Ahmed, A., Parthiban, C., Chetan Kumar, N., D’Souza, G., Baltissen, M.P., Martens, J.H.A., Domínguez-Andrés, J., Li, Y., Vyakarnam, A., Netea, M.G
Pubblicato in: Microbiology Spectrum, 2023, ISSN 2165-0497
Editore: American Society for Microbiology
DOI: 10.1128/spectrum.00231-23

IRF7 and RNH1 are modifying factors of HIV-1 reservoirs: a genome-wide association analysis.

Autori: Zhenhua Zhang; Wim Trypsteen; Marc Blaauw; Xiaojing Chu; Xiaojing Chu; Sofie Rutsaert; Linos Vandekerckhove; Wouter A. van der Heijden; Jéssica Cristina dos Santos; Cheng-Jian Xu; Morris A. Swertz; André J. A. M. van der Ven; Yang Li
Pubblicato in: BMC Medicine, Numero 3, 2021, ISSN 1741-7015
Editore: BioMed Central
DOI: 10.1186/s12916-021-02156-5

Multi-Omics Approaches in Immunological Research

Autori: Chu, X., Zhang, B., Koeken, V., Gupta, M.K., Li, Y.
Pubblicato in: Frontiers in immunology, 2022, ISSN 1664-3224
Editore: Frontiers Media S.A.
DOI: 10.3389/fimmu.2021.668045

Evolutionary Trajectories of Complex Traits in European Populations of Modern Humans

Autori: Yunus Kuijpers; Jorge Domínguez-Andrés; Olivier B. Bakker; Manoj Kumar Gupta; Martin Grasshoff; Cheng-Jian Xu; Leo A.B. Joosten; Jaume Bertranpetit; Mihai G. Netea; Yang Li
Pubblicato in: Frontiers in Genetics, Numero 3, 2022, ISSN 1664-8021
Editore: Frontiers Media
DOI: 10.3389/fgene.2022.833190

Plasma metabolome predicts trained immunity responses after antituberculosis BCG vaccination

Autori: Koeken, V.A.C.M., Qi, C., Mourits, V.P., de Bree, L.C.J., Moorlag, S.J.C.F.M., Sonawane, V., Heidi Lemmers, Dijkstra, H., Joosten, L.A.B., van Laarhoven, A., Xu, C.-J., van Crevel, R., Netea, M.G., Li, Y
Pubblicato in: PLoS Biology, 2022, ISSN 1544-9173
Editore: Public Library of Science
DOI: 10.1371/journal.pbio.3001765

The role of DNA methylation in personalized medicine for immune-related diseases

Autori: Gupta, M.K., Peng, H., Li, Y., Xu, C.-J.
Pubblicato in: Pharmacology & Therapeutics, 2023, ISSN 0163-7258
Editore: Pergamon Press
DOI: 10.1016/j.pharmthera.2023.108508

The Genetic Risk for COVID-19 Severity Is Associated With Defective Immune Responses

Autori: Kuijpers, Y., Chu, X., Jaeger, M., Moorlag, S.J.C.F.M., Koeken, V.A.C.M., Zhang, B., de Nooijer, A., Grondman, I., Gupta, M.K., Janssen, N., Mourits, V.P., de Bree, L.C.J., de Mast, Q., van de Veerdonk, F.L., Joosten, L.A.B., L,i Y., Netea, M.G., Xu, C.J.
Pubblicato in: Frontiers in Immunology, 2022, ISSN 1664-3224
Editore: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.859387

Evolution of cytokine production capacity in ancient and modern European populations

Autori: Jorge Domínguez-Andrés; Yunus Kuijpers; Olivier B. Bakker; Martin Jaeger; Cheng-Jian Xu; Cheng-Jian Xu; Jos W. M. van der Meer; Mattias Jakobsson; Mattias Jakobsson; Jaume Bertranpetit; Leo A. B. Joosten; Yang Li; Mihai G. Netea; Mihai G. Netea
Pubblicato in: eLife, Numero 4, 2021, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.1101/2021.01.14.426690

Resolving trained immunity with systems biology

Autori: Valerie A. C. M. Koeken; Valerie A. C. M. Koeken; Reinout van Crevel; Mihai G. Netea; Mihai G. Netea; Yang Li; Yang Li
Pubblicato in: European Journal of Immunology, Numero 3, 2021, ISSN 0014-2980
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202048882

A genome-wide functional genomics approach uncovers genetic determinants of immune phenotypes in type 1 diabetes

Autori: "Chu, X., Janssen, A.W.M., Koenen, H., Chang, L., He, X., Joosten, I., Stienstra, R., Kuijpers, Y., Wijmenga, C., Xu, C.- J., Netea, M.G, Tack, C.J., Li, Y.#"
Pubblicato in: eLife, 2022, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.73709

Single-cell RNA sequencing reveals induction of distinct trained immunity programs in human monocytes.

Autori: "Zhang, B., Moorlag, S., Domínguez-Andrés, J., Bulut, Ö., Kilic, G., Liu, Z., van Crevel, R., Xu,C.-J., Joosten, L.A.B., Netea, M.G.#, Li, Y.#"
Pubblicato in: Journal of Clinical investigation, 2022, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci147719

Single-Cell RNA Sequencing of Peripheral Blood Mononuclear Cells From Pediatric Coeliac Disease Patients Suggests Potential Pre-Seroconversion Markers

Autori: Aarón D. Ramírez-Sánchez; Xiaojing Chu; Rutger Modderman; Yvonne Kooy-Winkelaar; Sibylle Koletzko; Ilma R. Korponay-Szabó; Riccardo Troncone; Cisca Wijmenga; Luisa Mearin; Sebo Withoff; Iris H. Jonkers; Yang Li
Pubblicato in: Frontiers in Immunology, Numero 2, 2022, ISSN 1664-3224
Editore: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.843086

Induction of trained immunity by influenza vaccination - impact on COVID-19.

Autori: Priya A. Debisarun; Katharina L. Gössling; Ozlem Bulut; Gizem Kilic; Martijn Zoodsma; Zhaoli Liu; Marina Oldenburg; Nadine Rüchel; Bowen Zhang; Cheng-Jian Xu; Cheng-Jian Xu; Patrick Struycken; Valerie A. C. M. Koeken; Valerie A. C. M. Koeken; Jorge Domínguez-Andrés; Simone J.C.F.M. Moorlag; Esther Taks; Philipp Niklas Ostermann; Lisa Müller; Heiner Schaal; Ortwin Adams; Arndt Borkhardt; Jaap
Pubblicato in: Plos Pathogens, Numero 3, 2021, ISSN 1553-7366
Editore: Public Library of Science
DOI: 10.1371/journal.ppat.1009928

Altered and allele-specific open chromatin landscape reveals epigenetic and genetic regulators of innate immunity in COVID-19

Autori: Zhang, B., Zhang, Z., Koeken, V.A.C.M., Kumar, S., Aillaud, M., Tsay, H.-C., Liu, Z., Kraft, A.R.M., Soon, C.F., Odak, I., Bošnjak, B., Vlot, A., Deutsche COVID-19 OMICS Initiative (DeCOI), Swertz, M.A., Ohler, U., Geffers, R., Illig, T., Huehn, J., Saliba, A.E., Sander, L.E., Förster, R., Xu, C.-J., Cornberg, M., Schulte, L.N., Li, Y
Pubblicato in: Cell Genomics, 2023, ISSN 2666-979X
Editore: Elsevier
DOI: 10.1016/j.xgen.2022.100232

Metabolomics meets systems immunology

Autori: Fu, J., Zhu, F., Xu, C.-J., Li, Y
Pubblicato in: EMBO Reports, 2023, ISSN 1469-221X
Editore: Nature Publishing Group
DOI: 10.15252/embr.202255747