Cross-omics integration to identify modulators for improving vaccine efficacy

Información del proyecto

ModVaccine

Identificador del acuerdo de subvención: 948207

DOI

10.3030/948207

Fecha de la firma de la CE 14 Diciembre 2020

Fecha de inicio 1 Enero 2021

Fecha de finalización 31 Diciembre 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - European Research Council (ERC)

Coste total

€ 1 499 871,00

Aportación de la UE

€ 1 499 871,00

Coordinado por

HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (21)

Immune memory in individuals with COVID-19

Autores: Netea M.G., Li Y.
Publicado en: Nature Cell Biology, 2021, ISSN 1465-7392
Editor: Nature Publishing Group
DOI: 10.1038/s41556-021-00689-8

Tan, I. L., Coutinho de Almeida, R., Modderman, R., Stachurska, A., Dekens, J., Barisani, D., Meijer, C. R., Roca, M., Martinez-Ojinaga, E., Shamir, R., Auricchio, R., Korponay-Szabó, I. R., Castillejo, G., Szajewska, H., Koletzko, S., Zhernakova, A., Kumar, V., Li, Y., Visschedijk, M. C., Weersma, R. K., Withoff, S.

Autores: Circulating miRNAs as Potential Biomarkers for Celiac Disease Development.
Publicado en: Frontiers in immunology, 2021, ISSN 1664-3224
Editor: Frontiers Media S.A.
DOI: 10.3389/fimmu.2021.734763

Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment

Autores: Schulte-Schrepping J, Reusch N, Paclik D, Baßler K, Schlickeiser S, Zhang B, Krämer B, Krammer T, Brumhard S, Bonaguro L, De Domenico E, Wendisch D, Grasshoff M, Kapellos TS, Beckstette M, Pecht T, Saglam A, Dietrich O, Mei HE, Schulz AR, Conrad C, Kunkel D, Vafadarnejad E, Xu CJ, Horne A, Herbert M, Drews A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, Müller-Redetzky H, Heim KM, Machleidt
Publicado en: Cell, 2020, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2020.08.001

Multi-Omics Integration Reveals Only Minor Long-Term Molecular and Functional Sequelae in Immune Cells of Individuals Recovered From COVID-19

Autores: Liu, Z., Kilic, G., Li, W., Bulut, O., Gupta, M.K., Zhang, B., Qi, C., Peng, H., Tsay, H.-C., Soon, C. F., Mekonnen, Y.A., van der Made, C. I., van Cranenbroek, B., Koenen, H. J. P. M., Simonetti, E., Diavatopoulos, D., de Jonge, M. I., Müller, L., Schaal, H., Ostermann, P. N., Cornberg, M., Eiz-Vesper, B., van de Veerdonk, F., van Crevel, R., Joosten, L A. B., Domínguez-Andrés, J., Xu, C.-J.,
Publicado en: Frontiers in Immunology, 2022, ISSN 1664-3224
Editor: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.838132

A single-cell view on host immune transcriptional response to in vivo BCG-induced trained immunity

Autores: Li, W., Moorlag, S., Koeken, V.C.A.M., Röring, R.J., L de Bree, C., Mourits, V.P., Gupta, M.K., Zhang, B., Fu, J., Zhang, Z., Grondman, I., van Meijgaarden, K.E., Zhou, L., Alaswad, A., Joosten, L.A.B., van Crevel, R., Xu, C.-J., Netea, M.G., Li, Y.
Publicado en: Cell reports, 2023, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2023.112487

Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease

Autores: Xiaojing Chu; Xiaojing Chu; Martin Jaeger; Joep Beumer; Olivier B. Bakker; Raul Aguirre-Gamboa; Marije Oosting; Sanne P. Smeekens; Simone J.C.F.M. Moorlag; Vera P. Mourits; Valerie A. C. M. Koeken; Valerie A. C. M. Koeken; Charlotte de Bree; Trees Jansen; Ian T. Mathews; Ian T. Mathews; Khoi Dao; Mahan Najhawan; Jeramie D. Watrous; Irma Joosten; Sonia Sharma; Hans J. P. M. Koenen; Sebo Withoff; Ir
Publicado en: Genome Biology, Edición 3, 2021, ISSN 1474-760X
Editor: BioMed Central
DOI: 10.1186/s13059-021-02413-z

Differences in Immune Responses in Individuals of Indian and European Origin: Relevance for the COVID-19 Pandemic

Autores: Geckin, B., Zoodsma, M., Kilic, G., Debisarun, P.A., Rakshit, S., Adiga, V., Ahmed, A., Parthiban, C., Chetan Kumar, N., D’Souza, G., Baltissen, M.P., Martens, J.H.A., Domínguez-Andrés, J., Li, Y., Vyakarnam, A., Netea, M.G
Publicado en: Microbiology Spectrum, 2023, ISSN 2165-0497
Editor: American Society for Microbiology
DOI: 10.1128/spectrum.00231-23

IRF7 and RNH1 are modifying factors of HIV-1 reservoirs: a genome-wide association analysis.

Autores: Zhenhua Zhang; Wim Trypsteen; Marc Blaauw; Xiaojing Chu; Xiaojing Chu; Sofie Rutsaert; Linos Vandekerckhove; Wouter A. van der Heijden; Jéssica Cristina dos Santos; Cheng-Jian Xu; Morris A. Swertz; André J. A. M. van der Ven; Yang Li
Publicado en: BMC Medicine, Edición 3, 2021, ISSN 1741-7015
Editor: BioMed Central
DOI: 10.1186/s12916-021-02156-5

Multi-Omics Approaches in Immunological Research

Autores: Chu, X., Zhang, B., Koeken, V., Gupta, M.K., Li, Y.
Publicado en: Frontiers in immunology, 2022, ISSN 1664-3224
Editor: Frontiers Media S.A.
DOI: 10.3389/fimmu.2021.668045

Evolutionary Trajectories of Complex Traits in European Populations of Modern Humans

Autores: Yunus Kuijpers; Jorge Domínguez-Andrés; Olivier B. Bakker; Manoj Kumar Gupta; Martin Grasshoff; Cheng-Jian Xu; Leo A.B. Joosten; Jaume Bertranpetit; Mihai G. Netea; Yang Li
Publicado en: Frontiers in Genetics, Edición 3, 2022, ISSN 1664-8021
Editor: Frontiers Media
DOI: 10.3389/fgene.2022.833190

Plasma metabolome predicts trained immunity responses after antituberculosis BCG vaccination

Autores: Koeken, V.A.C.M., Qi, C., Mourits, V.P., de Bree, L.C.J., Moorlag, S.J.C.F.M., Sonawane, V., Heidi Lemmers, Dijkstra, H., Joosten, L.A.B., van Laarhoven, A., Xu, C.-J., van Crevel, R., Netea, M.G., Li, Y
Publicado en: PLoS Biology, 2022, ISSN 1544-9173
Editor: Public Library of Science
DOI: 10.1371/journal.pbio.3001765

The role of DNA methylation in personalized medicine for immune-related diseases

Autores: Gupta, M.K., Peng, H., Li, Y., Xu, C.-J.
Publicado en: Pharmacology & Therapeutics, 2023, ISSN 0163-7258
Editor: Pergamon Press
DOI: 10.1016/j.pharmthera.2023.108508

The Genetic Risk for COVID-19 Severity Is Associated With Defective Immune Responses

Autores: Kuijpers, Y., Chu, X., Jaeger, M., Moorlag, S.J.C.F.M., Koeken, V.A.C.M., Zhang, B., de Nooijer, A., Grondman, I., Gupta, M.K., Janssen, N., Mourits, V.P., de Bree, L.C.J., de Mast, Q., van de Veerdonk, F.L., Joosten, L.A.B., L,i Y., Netea, M.G., Xu, C.J.
Publicado en: Frontiers in Immunology, 2022, ISSN 1664-3224
Editor: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.859387

Evolution of cytokine production capacity in ancient and modern European populations

Autores: Jorge Domínguez-Andrés; Yunus Kuijpers; Olivier B. Bakker; Martin Jaeger; Cheng-Jian Xu; Cheng-Jian Xu; Jos W. M. van der Meer; Mattias Jakobsson; Mattias Jakobsson; Jaume Bertranpetit; Leo A. B. Joosten; Yang Li; Mihai G. Netea; Mihai G. Netea
Publicado en: eLife, Edición 4, 2021, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.1101/2021.01.14.426690

Resolving trained immunity with systems biology

Autores: Valerie A. C. M. Koeken; Valerie A. C. M. Koeken; Reinout van Crevel; Mihai G. Netea; Mihai G. Netea; Yang Li; Yang Li
Publicado en: European Journal of Immunology, Edición 3, 2021, ISSN 0014-2980
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/eji.202048882

A genome-wide functional genomics approach uncovers genetic determinants of immune phenotypes in type 1 diabetes

Autores: "Chu, X., Janssen, A.W.M., Koenen, H., Chang, L., He, X., Joosten, I., Stienstra, R., Kuijpers, Y., Wijmenga, C., Xu, C.- J., Netea, M.G, Tack, C.J., Li, Y.#"
Publicado en: eLife, 2022, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.73709

Single-cell RNA sequencing reveals induction of distinct trained immunity programs in human monocytes.

Autores: "Zhang, B., Moorlag, S., Domínguez-Andrés, J., Bulut, Ö., Kilic, G., Liu, Z., van Crevel, R., Xu,C.-J., Joosten, L.A.B., Netea, M.G.#, Li, Y.#"
Publicado en: Journal of Clinical investigation, 2022, ISSN 0021-9738
Editor: American Society for Clinical Investigation
DOI: 10.1172/jci147719

Single-Cell RNA Sequencing of Peripheral Blood Mononuclear Cells From Pediatric Coeliac Disease Patients Suggests Potential Pre-Seroconversion Markers

Autores: Aarón D. Ramírez-Sánchez; Xiaojing Chu; Rutger Modderman; Yvonne Kooy-Winkelaar; Sibylle Koletzko; Ilma R. Korponay-Szabó; Riccardo Troncone; Cisca Wijmenga; Luisa Mearin; Sebo Withoff; Iris H. Jonkers; Yang Li
Publicado en: Frontiers in Immunology, Edición 2, 2022, ISSN 1664-3224
Editor: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.843086

Induction of trained immunity by influenza vaccination - impact on COVID-19.

Autores: Priya A. Debisarun; Katharina L. Gössling; Ozlem Bulut; Gizem Kilic; Martijn Zoodsma; Zhaoli Liu; Marina Oldenburg; Nadine Rüchel; Bowen Zhang; Cheng-Jian Xu; Cheng-Jian Xu; Patrick Struycken; Valerie A. C. M. Koeken; Valerie A. C. M. Koeken; Jorge Domínguez-Andrés; Simone J.C.F.M. Moorlag; Esther Taks; Philipp Niklas Ostermann; Lisa Müller; Heiner Schaal; Ortwin Adams; Arndt Borkhardt; Jaap
Publicado en: Plos Pathogens, Edición 3, 2021, ISSN 1553-7366
Editor: Public Library of Science
DOI: 10.1371/journal.ppat.1009928

Altered and allele-specific open chromatin landscape reveals epigenetic and genetic regulators of innate immunity in COVID-19

Autores: Zhang, B., Zhang, Z., Koeken, V.A.C.M., Kumar, S., Aillaud, M., Tsay, H.-C., Liu, Z., Kraft, A.R.M., Soon, C.F., Odak, I., Bošnjak, B., Vlot, A., Deutsche COVID-19 OMICS Initiative (DeCOI), Swertz, M.A., Ohler, U., Geffers, R., Illig, T., Huehn, J., Saliba, A.E., Sander, L.E., Förster, R., Xu, C.-J., Cornberg, M., Schulte, L.N., Li, Y
Publicado en: Cell Genomics, 2023, ISSN 2666-979X
Editor: Elsevier
DOI: 10.1016/j.xgen.2022.100232

Metabolomics meets systems immunology

Autores: Fu, J., Zhu, F., Xu, C.-J., Li, Y
Publicado en: EMBO Reports, 2023, ISSN 1469-221X
Editor: Nature Publishing Group
DOI: 10.15252/embr.202255747