Deciphering the evolution and roles of cytosine DNA methylation across eukaryotes

Project Information

METHYLEVOL

Grant agreement ID: 950230

DOI

10.3030/950230

EC signature date 20 October 2020

Start date 1 September 2021

End date 31 December 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 499 965,00

EU contribution

€ 1 499 965,00

Coordinated by

QUEEN MARY UNIVERSITY OF LONDON
United Kingdom

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (10)

Annelid methylomes reveal ancestral developmental and aging-associated epigenetic erosion across Bilateria

Author(s): Kero Guynes, Luke A. Sarre, Allan M. Carrillo-Baltodano, Billie E. Davies, Lan Xu, Yan Liang, Francisco M. Martín-Zamora, Paul J. Hurd, Alex de Mendoza, José M. Martín-Durán
Published in: Genome Biology, Issue 25, 2024, ISSN 1474-760X
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/s13059-024-03346-z

Reconstructing the last common ancestor of all eukaryotes

Author(s): Thomas A. Richards, Laura Eme, John M. Archibald, Guy Leonard, Susana M. Coelho, Alex de Mendoza, Christophe Dessimoz, Pavel Dolezal, Lillian K. Fritz-Laylin, Toni Gabaldón, Vladimír Hampl, Geert J. P. L. Kops, Michelle M. Leger, Purificacion Lopez-Garcia, James O. McInerney, David Moreira, Sergio A. Muñoz-Gómez, Daniel J. Richter, Iñaki Ruiz-Trillo, Alyson E. Santoro, Arnau Sebé-Pedrós, Be
Published in: PLOS Biology, Issue 22, 2024, Page(s) e3002917, ISSN 1545-7885
Publisher: Public Library of Science (PLoS)
DOI: 10.1371/journal.pbio.3002917

The genomic origin of the unique chaetognath body plan

Author(s): Laura Piovani, Daria Gavriouchkina, Elise Parey, Luke A. Sarre, Katja T. C. A. Peijnenburg, José María Martín-Durán, Daniel S. Rokhsar, Noriyuki Satoh, Alex de Mendoza, Taichiro Goto, Ferdinand Marlétaz
Published in: Nature, Issue 645, 2025, Page(s) 964-973, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-025-09403-2

Chromatin loops are an ancestral hallmark of the animal regulatory genome

Author(s): Iana V. Kim, Cristina Navarrete, Xavier Grau-Bové, Marta Iglesias, Anamaria Elek, Grygoriy Zolotarov, Nikolai S. Bykov, Sean A. Montgomery, Ewa Ksiezopolska, Didac Cañas-Armenteros, Joan J. Soto-Angel, Sally P. Leys, Pawel Burkhardt, Hiroshi Suga, Alex de Mendoza, Marc A. Marti-Renom, Arnau Sebé-Pedrós
Published in: Nature, Issue 642, 2025, Page(s) 1097-1105, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-025-08960-w

Specific DNMT3C flanking sequence preferences facilitate methylation of young murine retrotransposons

Author(s): Leonie Dossmann, Max Emperle, Michael Dukatz, Alex de Mendoza, Pavel Bashtrykov, Albert Jeltsch
Published in: Communications Biology, Issue 7, 2024, ISSN 2399-3642
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s42003-024-06252-z

Repressive Cytosine Methylation is a Marker of Viral Gene Transfer Across Divergent Eukaryotes

Author(s): Luke A Sarre, Giselle Azucena Gastellou Peralta, Pedro Romero Charria, Vladimir Ovchinnikov, Alex de Mendoza
Published in: Molecular Biology and Evolution, Issue 42, 2025, ISSN 0737-4038
Publisher: Oxford University Press
DOI: 10.1093/molbev/msaf176

Epigenetic silencing and genome dynamics determine the fate of giant virus endogenizations in Acanthamoeba

Author(s): Cédric Blais, Morgan J. Colp, Luke A. Sarre, Alex de Mendoza, John M. Archibald
Published in: BMC Biology, Issue 23, 2025, ISSN 1741-7007
Publisher: BioMed Central
DOI: 10.1186/s12915-025-02280-1

DNA methylation enables recurrent endogenization of giant viruses in an animal relative

Author(s): Luke A. Sarre, Iana V. Kim, Vladimir Ovchinnikov, Marine Olivetta, Hiroshi Suga, Omaya Dudin, Arnau Sebé-Pedrós, Alex de Mendoza
Published in: Science Advances, Issue 10, 2024, ISSN 2375-2548
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/sciadv.ado6406

The emergence of Sox and POU transcription factors predates the origins of animal stem cells

Author(s): Ya Gao, Daisylyn Senna Tan, Mathias Girbig, Haoqing Hu, Xiaomin Zhou, Qianwen Xie, Shi Wing Yeung, Kin Shing Lee, Sik Yin Ho, Vlad Cojocaru, Jian Yan, Georg K. A. Hochberg, Alex de Mendoza, Ralf Jauch
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-54152-x

Adenine DNA methylation associated with transcriptionally permissive chromatin is widespread across eukaryotes

Author(s): Pedro Romero Charria, Cristina Navarrete, Vladimir Ovchinnikov, Lan Xu, Luke A. Sarre, Victoria Shabardina, Ewa Ksiezopolska, Elena Casacuberta, David Lara-Astiaso, Arnau Sebé-Pedrós, Alex de Mendoza
Published in: Nature Genetics, Issue 57, 2025, Page(s) 3126-3136, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-025-02409-6

Non-peer reviewed articles (1)

Genome synteny reveals hidden enhancer conservation

Author(s): Alex de Mendoza
Published in: Nature Genetics, Issue 57, 2025, Page(s) 1328-1329, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-025-02194-2