ULtrafine particles from TRansportation – Health Assessment of Sources

Projektinformationen

ULTRHAS

ID Finanzhilfevereinbarung: 955390

DOI

10.3030/955390

EK-Unterschriftsdatum 26 März 2021

Startdatum 1 September 2021

Enddatum 30 November 2025

Finanziert unter

• SOCIETAL CHALLENGES - Smart, Green And Integrated Transport

Gesamtkosten

€ 4 322 206,25

EU-Beitrag

€ 4 037 501,25

Koordiniert durch

FOLKEHELSEINSTITUTTET
Norway

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Links zu Ergebnissen und Veröffentlichungen von RP7-Projekten sowie Links zu einigen Typen spezifischer Ergebnisse wie Datensätzen und Software werden dynamisch von OpenAIRE abgerufen.

Leistungen

Documents, reports (15)

Project Management Plan

This deliverable will describe a detailed Project Management Plan with a Gantt chart and a Work Breakdown Structure (WBS). It wil include a schedule per task, responsible partner related subtasks, related deliverables, and dependencies on other tasks.

Report on areosol and UFPs characteristics from high performance engines

This deliverable will describe the results concerning the chemical and physical characterization of exhaust emissions from high-power engines. The deliverable will include information on primary and aged aerosols and UFPs from the exhaust of a ship diesel engine, a medium duty gas engine and the jet engine combustor test rig.

Report on particles/ particle components and cell mediators

This deliverable will provide a complete characterization of conditioned cell culture medium from CAST generated particles exposed lung tissues The deliverable will include information on UFP translocation particle adhered chemicals and cytokine chemokines released by lung cells

Characterization of selected policies

This delivery will describe a set of inter- and intrasectional transportation policy options that have been selected for health benefit analysis. The selection is based on hazard and exposure ranking of the emissions that the policy will impact. Description of the policies will include, among others, a priori assumptions, selection criteria and changes in emissions.

Report on direct vs. indirect effects on human intestine tissue

This deliverable will report on inflammatory and genotoxic effects of UFPs in intestinal tissue. The deliverable will include information on 3D cultures of human intestine cultures exposed directly to CAST generated particles or to conditioned medium from particle exposed lung tissue.

Report on high-power engine emission and aging on lung tissue models

This deliverable will report on the biological effects of ehaust emisssions from high-power engine in lung tissue. The deliverable will include infomation on bothy primary and aged aerosols and UFPs on (geno)toxicological outcomes in in vitro ALI models.

Report on areosol and UFPs characteristics from non-exhaust sources

This deliverable will report on the results concerning the chemical and physical characterization of non-exhaust esmissions from transport modes. The deliverable will include information on aerosols and UFPs from vehicle brake emissions and rail caternary sparkling.

Report on CAST-generated UFP effects

This deliverable will report on dosymetry considerations and chemical composition related to both primary and secondary (geno)toxicological effects of UFPs. The deliverable will provide information on CAST-generated model emisssions in lung tissue models at ALI.

Exploitation plan

This deliverable will report on exploitation activities involving reaching out to, and building collaborations with, key experts, external organisations. The deliverable will describe end-users.

Report on mechanical generated UFP effects

This deliverable will report on the biological effects of non-exhaust transport mode emissions in lung tissue. The deliverable will include infomation on effects of UFPs and metals/metal ions on (geno)toxicological outcomes in in vitro ALI models.

IPR & Innovation Strategy

This deliverable will present to the Commision innovation potential identified on the background of findings and a strategy for innvolvement of potential extnal parties in innovation exploitiationThe IPR strategy will include both preexisting knowledge and knowledge generated in this project

Report on light-duty vehicle emission and aging effects

This deliverable will report on the biological effects of ehaust emisssions from light-duty engine in lung tissue. The deliverable will include infomation on bothy primary and aged aerosols and UFPs on (geno)toxicological outcomes in in vitro ALI models.

Project Management Plan- first update

Fist update of a detailed Project Management Planwith a Gantt chart and a Work Breakdown Structure WBS It wil include a schedule per task responsible partner related subtasks related deliverables and dependencies on other tasks

Project CD plan and website

Communication and dissemination (CD) strategy and plan will describe target audiences, key messages for each stakeholder and the use of different channels and tools for management and monitoring of effective and efficient CD activities. The project website will in addition encompass internal consortium communication .

Project Management Plan- second update

Second update of a detailed Project Management Plan with a Gantt chart and a Work Breakdown Structure (WBS). It wil include a schedule per task, responsible partner related subtasks, related deliverables, and dependencies on other tasks.

Other (1)

Establishment of Scientific Advisory Board

This deliverable will describe the Scientific Advisory Board's mandate. The deliverable will also include a list of the SAB-members and their expertise.

Veröffentlichungen

Peer reviewed articles (10)

Sources of PM2.5 exposure misclassification in three Finnish register-based study populations and the impact on attenuation of health effect estimates

Autoren: Antti Korhonen, Isabell Katharina Rumrich, Marjut Roponen, Lise M. Frohn, Camilla Geels, Jørgen Brandt, Anna-Maija Tolppanen, Otto Hänninen
Veröffentlicht in: Science of The Total Environment, Ausgabe 954, 2024, Seite(n) 176422, ISSN 0048-9697
Herausgeber: Elsevier BV
DOI: 10.1016/j.scitotenv.2024.176422

Combining analytical techniques to assess the translocation of diesel particles across an alveolar tissue barrier in vitro

Autoren: Gowsinth Gunasingam; Ruiwen HE; Patricia Taladriz-Blanco; Sandor Balog; Alke Petri-Fink; Barbara Rothen-Rutishauser
Veröffentlicht in: Particle and Fibre Toxicology, Ausgabe 21:26, 2024, 2024, ISSN 1743-8977
Herausgeber: BioMed Central
DOI: 10.1186/s12989-024-00585-7

Molecular composition of fresh and aged aerosols from residential wood combustion and gasoline car with modern emission mitigation technology

Autoren: Eric Schneider, Hendryk Czech, Anni Hartikainen, Helly J. Hansen, Nadine Gawlitta, Mika Ihalainen, Pasi Yli-Pirilä, Markus Somero, Miika Kortelainen, Juho Louhisalmi, Jürgen Orasche, Zheng Fang, Yinon Rudich, Olli Sippula, Christopher P. Rüger, Ralf Zimmermann
Veröffentlicht in: Environmental Science: Processes & Impacts, Ausgabe 26, 2024, Seite(n) 1295-1309, ISSN 2050-7887
Herausgeber: Royal Society of Chemistry
DOI: 10.1039/d4em00106k

Lung cancer associated with combustion particles and fine particulate matter (PM2.5) - The roles of polycyclic aromatic hydrocarbons (PAHs) and the aryl hydrocarbon receptor (AhR)

Autoren: Jørn A. Holme, Jan Vondráček, Miroslav Machala, Dominique Lagadic-Gossmann, Christoph F.A. Vogel, Eric Le Ferrec, Lydie Sparfel, Johan Øvrevik
Veröffentlicht in: Biochemical Pharmacology, Ausgabe 216, 2024, Seite(n) 115801, ISSN 0006-2952
Herausgeber: Elsevier BV
DOI: 10.1016/j.bcp.2023.115801

Personal measurements and sampling of particulate matter in a subway – Identification of hot-spots, spatio-temporal variability and sources of pollutants

Autoren: Jan Bendl, Carsten Neukirchen, Ajit Mudan, Sara Padoan, Ralf Zimmermann, Thomas Adam
Veröffentlicht in: Atmospheric Environment, Ausgabe 308, 2023, Seite(n) 119883, ISSN 1352-2310
Herausgeber: Elsevier BV
DOI: 10.1016/j.atmosenv.2023.119883

Generation, characterization, and toxicological assessment of reference ultrafine soot particles with different organic content for inhalation toxicological studies

Autoren: Anusmita Das, Jana Pantzke, Seongho Jeong, Elena Hartner, Elias J. Zimmermann, Nadine Gawlitta, Svenja Offer, Deeksha Shukla, Anja Huber, Narges Rastak, Arūnas Meščeriakovas, Natalia P. Ivleva, Evelyn Kuhn, Stephanie Binder, Thomas Gröger, Sebastian Oeder, Mathilde Delaval, Hendryk Czech, Olli Sippula, Jürgen Schnelle-Kreis, Sebastiano Di Bucchianico, Martin Sklorz, Ralf Zimmermann
Veröffentlicht in: Science of The Total Environment, Ausgabe 951, 2024, Seite(n) 175727, ISSN 0048-9697
Herausgeber: Elsevier BV
DOI: 10.1016/j.scitotenv.2024.175727

Adverse neurodevelopment in children associated with prenatal exposure to fine particulate matter (PM2.5) – Possible roles of polycyclic aromatic hydrocarbons (PAHs) and mechanisms involved

Autoren: Jørn A. Holme, Oddvar Myhre, Johan Øvrevik
Veröffentlicht in: Reproductive Toxicology, Ausgabe 130, 2024, Seite(n) 108718, ISSN 0890-6238
Herausgeber: Elsevier BV
DOI: 10.1016/j.reprotox.2024.108718

Effects of fuel composition and vehicle operating temperature on <i>in vitro</i> toxicity of exhaust emissions

Autoren: Henri Hakkarainen, Anssi Järvinen, Teemu Lepistö, Niina Kuittinen, Lassi Markkula, Tuukka Ihantola, Mo Yang, Maria-Viola Martikainen, Santtu Mikkonen, Hilkka Timonen, Minna Aurela, Luis Barreira, Mika Ihalainen, Sanna Saarikoski, Topi Rönkkö, Päivi Aakko-Saksa, Pasi Jalava
Veröffentlicht in: Environmental Science: Atmospheres, Ausgabe 4, 2024, Seite(n) 455-467, ISSN 2634-3606
Herausgeber: Royal Society of Chemistry
DOI: 10.1039/d3ea00136a

Automated SEM/EDX imaging for the in-depth characterization of non-exhaust traffic emissions from the Munich subway system

Autoren: Carsten Neukirchen, Thorsten Meiners, Jan Bendl, Ralf Zimmermann, Thomas Adam
Veröffentlicht in: Science of The Total Environment, Ausgabe 915, 2024, Seite(n) 170008, ISSN 0048-9697
Herausgeber: Elsevier BV
DOI: 10.1016/j.scitotenv.2024.170008

The effects of fine particulate matter (SRM 2786) on three different 3D lung models exposed at the air-liquid interface – A comparative study

Autoren: Vegard Sæter Grytting, Tonje Skuland, Jarle Ballangby, Magne Refsnes, Marit Låg, Johan Øvrevik, Espen Mariussen
Veröffentlicht in: Toxicology in Vitro, Ausgabe 98, 2024, Seite(n) 105841, ISSN 0887-2333
Herausgeber: Elsevier BV
DOI: 10.1016/j.tiv.2024.105841

Conference proceedings (3)

68 On the Role of Chemical Identity over the size of Model Ultrafine Particles Driven (geno)-Toxicity

Autoren: Jana Pantzke, Anusmita Das, Elias J Zimmermann, Svenja Offer, Seongho Jeong, Mathilde N Delaval, Jürgen Schnelle-Kreis, Martin Sklorz, Sebastiano Di Bucchianico, Ralf Zimmermann
Veröffentlicht in: Annals of Work Exposures and Health, Ausgabe 67, 2023, Seite(n) i93-i93, ISSN 2398-7308
Herausgeber: Oxford Academic
DOI: 10.1093/annweh/wxac087.227

22 Development of an Integrated Exposure Pathway Model for Health Impact Assessment of Traffic Ultrafine Particles (H2020 Ultrhas-Project)

Autoren: Antti Korhonen, Heli Lehtomäki, Isabell Rumrich, Marjut Roponen, Anette Bølling, Gunn Marit Aasvang, Pasi Jalava, Barbara Rothen-Rutishauser, Sebastiano Di Bucchianico, Ralf Zimmermann, Johan Øvrevik, Otto Hänninen
Veröffentlicht in: Annals of Work Exposures and Health, Ausgabe 67, 2023, Seite(n) i78-i79, ISSN 2398-7308
Herausgeber: Oxford Academic
DOI: 10.1093/annweh/wxac087.190

127 Photochemical Aging Increases Toxicity of EURO 6 Gasoline Car Exhaust in Lung Epithelial Cells at the Air-Liquid Interface

Autoren: Mathilde N Delaval, Hendryk Czech, Mohammad Almasaleekh, Svenja Offer, Mika Ihalainen, Pasi Yli-Pirilä, Thorsten Hohaus, Markus Kalberer, Sebastiano Di Bucchianico, Olli Sippula, Yinon Rudich, Ralf Zimmermann, null null
Veröffentlicht in: Annals of Work Exposures and Health, Ausgabe 67, 2023, Seite(n) i69-i69, ISSN 2398-7308
Herausgeber: Oxford Academic
DOI: 10.1093/annweh/wxac087.166