Innvative approaches to identification of metabolic Targets for antimicrobials

Project Information

INNOTARGETS

Grant agreement ID: 956154

DOI

10.3030/956154

Project closed

EC signature date 13 August 2020

Start date 1 March 2021

End date 30 November 2025

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 3 260 954,70

EU contribution

€ 3 260 954,70

Coordinated by

KOBENHAVNS UNIVERSITET
Denmark

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (1)

At least 6 outreach and dissemination events (as per Table 2.3a and 2.4)

At least 6 outreach and dissemination events as per Table 23a and 24 have been completed

Websites, patent fillings, videos etc. (1)

INNOTARGETS website and other social media online

INNOTARGETS website and other social media is online

Publications

Peer reviewed articles (16)

Optimizing phage-based mutant recovery and minimizing heat effect in the construction of transposon libraries in Staphylococcus aureus

Author(s): Sally W. Yousief, Nader Abdelmalek, Bianca Paglietti
Published in: Scientific Reports, Issue 14, 2024, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-024-73731-y

Chromosomal genes modulating fosfomycin susceptibility in uropathogenic <i>Escherichia coli</i> : a genome-wide analysis

Author(s): Yibing Ma, Mattia Pirolo, Lily Giarratana, Karen Leth Nielsen, Susanne Häussler, Luca Guardabassi
Published in: Antimicrobial Agents and Chemotherapy, Issue 69, 2025, ISSN 0066-4804
Publisher: American Society for Microbiology
DOI: 10.1128/aac.01417-24

Algebraic differentiation for fast sensitivity analysis of optimal flux modes in metabolic models

Author(s): Hester Chapman, Miroslav Kratochvíl, Oliver Ebenhöh, St Elmo Wilken
Published in: Bioinformatics, Issue 41, 2025, ISSN 1367-4811
Publisher: Oxford University Press (OUP)
DOI: 10.1093/bioinformatics/btaf287

The Secondary Resistome of Methicillin-Resistant Staphylococcus aureus to β-Lactam Antibiotics

Author(s): Nader Abdelmalek, Sally Waheed Yousief, Martin Saxtorph Bojer, Mosaed Saleh A. Alobaidallah, John Elmerdahl Olsen, Bianca Paglietti
Published in: Antibiotics, Issue 14, 2025, Page(s) 112, ISSN 2079-6382
Publisher: MDPI AG
DOI: 10.3390/antibiotics14020112

Exploring the susceptome of methicillin-resistant Staphylococcus aureus to oxacillin and cefazolin using integrated transposon-directed insertion site sequencing and proteomics

Author(s): Nader Abdelmalek, Sally W. Yousief, Alessandro Tanca, Martin S. Bojer, Mosaed Saleh A. Alobaidallah, John E. Olsen, Bianca Paglietti
Published in: International Journal of Antimicrobial Agents, Issue 66, 2025, Page(s) 107652, ISSN 0924-8579
Publisher: Elsevier BV
DOI: 10.1016/j.ijantimicag.2025.107652

A Novel Algorithm to Calculate Elementary Modes: Analysis of<i>Campylobacter jejuni</i>Metabolism

Author(s): Yanica Said, Dipali Singh, Cristiana Sebu, Mark Poolman
Published in: Biosystems, 2023, ISSN 1872-8324
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.01.11.521685

Early prediction of potential hepatotoxic metabolites to aid lead selection in drug discovery

Author(s): Linda Chiappalupi, Domingo Gargallo-Viola, Antoni Torrens
Published in: Open Research Europe, Issue 5, 2025, Page(s) 307, ISSN 2732-5121
Publisher: F1000 Research Ltd
DOI: 10.12688/openreseurope.21392.1

Genome-wide identification of tissue-specific fitness genes in murine models of Staphylococcus aureus infection

Author(s): Sally W. Yousief, Nader Abdelmalek, Martin S. Bojer, Yibing Ma, Priscila R. Guerra, Sajid Nisar, John E. Olsen, Bianca Paglietti
Published in: iScience, Issue 29, 2025, Page(s) 114261, ISSN 2589-0042
Publisher: Elsevier BV
DOI: 10.1016/j.isci.2025.114261

Deletion of pcnB affects antibiotic susceptibility in resistant Escherichia coli by reducing copy number of ColE1-family plasmids

Author(s): Sandra Marina Wellner, Xiao Fei, Ana Herrero-Fresno, John Elmerdahl Olsen
Published in: Scientific Reports, Issue 15, 2025, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-025-92308-x

The intrinsic macrolide resistome of <i>Escherichia coli</i>

Author(s): Yibing Ma, Mattia Pirolo, Bimal Jana, Viktor Hundtofte Mebus, Luca Guardabassi
Published in: Antimicrobial Agents and Chemotherapy, Issue 68, 2024, ISSN 0066-4804
Publisher: American Society for Microbiology
DOI: 10.1128/aac.00452-24

Screening Actinomycetes extracts for antimicrobial compounds against methicillin-resistant Staphylococcus aureus and helper-compounds against aminoglycoside-resistant E. coli

Author(s): Dina Al Nahhas, Sandra Marina Wellner, Margherita Sosio, Sonia I Maffioli, Salvatore Pisanu, Sergio Uzzau, Daniela Pagnozzi, Stefano Donadio, John Elmerdahl Olsen
Published in: Open Research Europe, Issue 5, 2025, Page(s) 110, ISSN 2732-5121
Publisher: F1000 Research Ltd
DOI: 10.12688/openreseurope.19988.1

Comparative proteomics analysis of MRSA under different experimental conditions

Author(s): Dina Al Nahhas, Salvatore Pisanu, Alessandro Tanca, Bianca Paglietti, Antonella Santona, Sergio Uzzau, Daniela Pagnozzi
Published in: Scientific Reports, Issue 15, 2025, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-025-04224-9

A novel high-throughput screening method for identifying compounds that inhibit plasmid conjugation

Author(s): Jennifer Moussa, Domingo Gargallo-Viola, Line Elnif Thomsen
Published in: MethodsX, Issue 12, 2025, Page(s) 102740, ISSN 2215-0161
Publisher: Elsevier BV
DOI: 10.1016/j.mex.2024.102740

Genome-wide identification of fitness-genes in aminoglycoside-resistant Escherichia coli during antibiotic stress

Author(s): Sandra Marina Wellner, Mosaed Saleh A. Alobaidallah, Xiao Fei, Ana Herrero-Fresno, John Elmerdahl Olsen
Published in: Scientific Reports, Issue 14, 2024, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-024-54169-8

Macrolide Resistance and In Vitro Potentiation by Peptidomimetics in Porcine Clinical Escherichia coli

Author(s): Yibing Ma, Mattia Pirolo https://orcid.org/0000-0002-9814-1500 Prabha Subramani, Ronette Gehring, Peter Damborg https://orcid.org/0000-0001-9932-5996 Henrik Franzyk https://orcid.org/0000-0002-2822-1927 Luca Guardabassi https://orcid.org/0000-0002-2389-5084
Published in: mSphere, Issue vol 7 number 5, 2023, ISSN 2379-5042
Publisher: American Society for Microbiology
DOI: 10.1128/msphere.00402-22

Genome-wide Identification of conditionally essential genes supporting <i>Streptococcus suis</i> growth in serum and cerebrospinal fluid

Author(s): Maria Juanpere-Borras, Tiantong Zhao, Jos Boekhorst, Blanca Fernandez-Ciruelos, Rajrita Sanyal, Nissa Arifa, Troy Wagenaar, Peter van Baarlen, Jerry M. Wells
Published in: Virulence, Issue 17, 2025, ISSN 2150-5594
Publisher: Landes Bioscience
DOI: 10.1080/21505594.2025.2600145