Innvative approaches to identification of metabolic Targets for antimicrobials

Información del proyecto

INNOTARGETS

Identificador del acuerdo de subvención: 956154

DOI

10.3030/956154

Proyecto cerrado

Fecha de la firma de la CE 13 Agosto 2020

Fecha de inicio 1 Marzo 2021

Fecha de finalización 30 Noviembre 2025

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 3 260 954,70

Aportación de la UE

€ 3 260 954,70

Coordinado por

KOBENHAVNS UNIVERSITET
Denmark

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (2)

At least 6 outreach and dissemination events (as per Table 2.3a and 2.4)

At least 6 outreach and dissemination events as per Table 23a and 24 have been completed

At least 22 other outreaches and dissemination event (as per Table 2.3a and 2.4)

At least 22 other outreaches and dissemination event (as per Table 2.3a and 2.4) have been held

Websites, patent fillings, videos etc. (1)

INNOTARGETS website and other social media online

INNOTARGETS website and other social media is online

Publicaciones

Peer reviewed articles (16)

Optimizing phage-based mutant recovery and minimizing heat effect in the construction of transposon libraries in Staphylococcus aureus

Autores: Sally W. Yousief, Nader Abdelmalek, Bianca Paglietti
Publicado en: Scientific Reports, Edición 14, 2024, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-024-73731-y

Chromosomal genes modulating fosfomycin susceptibility in uropathogenic <i>Escherichia coli</i> : a genome-wide analysis

Autores: Yibing Ma, Mattia Pirolo, Lily Giarratana, Karen Leth Nielsen, Susanne Häussler, Luca Guardabassi
Publicado en: Antimicrobial Agents and Chemotherapy, Edición 69, 2025, ISSN 0066-4804
Editor: American Society for Microbiology
DOI: 10.1128/aac.01417-24

Algebraic differentiation for fast sensitivity analysis of optimal flux modes in metabolic models

Autores: Hester Chapman, Miroslav Kratochvíl, Oliver Ebenhöh, St Elmo Wilken
Publicado en: Bioinformatics, Edición 41, 2025, ISSN 1367-4811
Editor: Oxford University Press (OUP)
DOI: 10.1093/bioinformatics/btaf287

The Secondary Resistome of Methicillin-Resistant Staphylococcus aureus to β-Lactam Antibiotics

Autores: Nader Abdelmalek, Sally Waheed Yousief, Martin Saxtorph Bojer, Mosaed Saleh A. Alobaidallah, John Elmerdahl Olsen, Bianca Paglietti
Publicado en: Antibiotics, Edición 14, 2025, Página(s) 112, ISSN 2079-6382
Editor: MDPI AG
DOI: 10.3390/antibiotics14020112

Exploring the susceptome of methicillin-resistant Staphylococcus aureus to oxacillin and cefazolin using integrated transposon-directed insertion site sequencing and proteomics

Autores: Nader Abdelmalek, Sally W. Yousief, Alessandro Tanca, Martin S. Bojer, Mosaed Saleh A. Alobaidallah, John E. Olsen, Bianca Paglietti
Publicado en: International Journal of Antimicrobial Agents, Edición 66, 2025, Página(s) 107652, ISSN 0924-8579
Editor: Elsevier BV
DOI: 10.1016/j.ijantimicag.2025.107652

A Novel Algorithm to Calculate Elementary Modes: Analysis of<i>Campylobacter jejuni</i>Metabolism

Autores: Yanica Said, Dipali Singh, Cristiana Sebu, Mark Poolman
Publicado en: Biosystems, 2023, ISSN 1872-8324
Editor: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.01.11.521685

Early prediction of potential hepatotoxic metabolites to aid lead selection in drug discovery

Autores: Linda Chiappalupi, Domingo Gargallo-Viola, Antoni Torrens
Publicado en: Open Research Europe, Edición 5, 2025, Página(s) 307, ISSN 2732-5121
Editor: F1000 Research Ltd
DOI: 10.12688/openreseurope.21392.1

Genome-wide identification of tissue-specific fitness genes in murine models of Staphylococcus aureus infection

Autores: Sally W. Yousief, Nader Abdelmalek, Martin S. Bojer, Yibing Ma, Priscila R. Guerra, Sajid Nisar, John E. Olsen, Bianca Paglietti
Publicado en: iScience, Edición 29, 2025, Página(s) 114261, ISSN 2589-0042
Editor: Elsevier BV
DOI: 10.1016/j.isci.2025.114261

Deletion of pcnB affects antibiotic susceptibility in resistant Escherichia coli by reducing copy number of ColE1-family plasmids

Autores: Sandra Marina Wellner, Xiao Fei, Ana Herrero-Fresno, John Elmerdahl Olsen
Publicado en: Scientific Reports, Edición 15, 2025, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-025-92308-x

The intrinsic macrolide resistome of <i>Escherichia coli</i>

Autores: Yibing Ma, Mattia Pirolo, Bimal Jana, Viktor Hundtofte Mebus, Luca Guardabassi
Publicado en: Antimicrobial Agents and Chemotherapy, Edición 68, 2024, ISSN 0066-4804
Editor: American Society for Microbiology
DOI: 10.1128/aac.00452-24

Screening Actinomycetes extracts for antimicrobial compounds against methicillin-resistant Staphylococcus aureus and helper-compounds against aminoglycoside-resistant E. coli

Autores: Dina Al Nahhas, Sandra Marina Wellner, Margherita Sosio, Sonia I Maffioli, Salvatore Pisanu, Sergio Uzzau, Daniela Pagnozzi, Stefano Donadio, John Elmerdahl Olsen
Publicado en: Open Research Europe, Edición 5, 2025, Página(s) 110, ISSN 2732-5121
Editor: F1000 Research Ltd
DOI: 10.12688/openreseurope.19988.1

Comparative proteomics analysis of MRSA under different experimental conditions

Autores: Dina Al Nahhas, Salvatore Pisanu, Alessandro Tanca, Bianca Paglietti, Antonella Santona, Sergio Uzzau, Daniela Pagnozzi
Publicado en: Scientific Reports, Edición 15, 2025, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-025-04224-9

A novel high-throughput screening method for identifying compounds that inhibit plasmid conjugation

Autores: Jennifer Moussa, Domingo Gargallo-Viola, Line Elnif Thomsen
Publicado en: MethodsX, Edición 12, 2025, Página(s) 102740, ISSN 2215-0161
Editor: Elsevier BV
DOI: 10.1016/j.mex.2024.102740

Genome-wide identification of fitness-genes in aminoglycoside-resistant Escherichia coli during antibiotic stress

Autores: Sandra Marina Wellner, Mosaed Saleh A. Alobaidallah, Xiao Fei, Ana Herrero-Fresno, John Elmerdahl Olsen
Publicado en: Scientific Reports, Edición 14, 2024, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-024-54169-8

Macrolide Resistance and In Vitro Potentiation by Peptidomimetics in Porcine Clinical Escherichia coli

Autores: Yibing Ma, Mattia Pirolo https://orcid.org/0000-0002-9814-1500 Prabha Subramani, Ronette Gehring, Peter Damborg https://orcid.org/0000-0001-9932-5996 Henrik Franzyk https://orcid.org/0000-0002-2822-1927 Luca Guardabassi https://orcid.org/0000-0002-2389-5084
Publicado en: mSphere, Edición vol 7 number 5, 2023, ISSN 2379-5042
Editor: American Society for Microbiology
DOI: 10.1128/msphere.00402-22

Genome-wide Identification of conditionally essential genes supporting <i>Streptococcus suis</i> growth in serum and cerebrospinal fluid

Autores: Maria Juanpere-Borras, Tiantong Zhao, Jos Boekhorst, Blanca Fernandez-Ciruelos, Rajrita Sanyal, Nissa Arifa, Troy Wagenaar, Peter van Baarlen, Jerry M. Wells
Publicado en: Virulence, Edición 17, 2025, ISSN 2150-5594
Editor: Landes Bioscience
DOI: 10.1080/21505594.2025.2600145