Innvative approaches to identification of metabolic Targets for antimicrobials

Informazioni relative al progetto

INNOTARGETS

ID dell’accordo di sovvenzione: 956154

DOI

10.3030/956154

Progetto chiuso

Data della firma CE 13 Agosto 2020

Data di avvio 1 Marzo 2021

Data di completamento 30 Novembre 2025

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale

€ 3 260 954,70

Contributo UE

€ 3 260 954,70

Coordinato da

KOBENHAVNS UNIVERSITET
Denmark

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (2)

At least 6 outreach and dissemination events (as per Table 2.3a and 2.4)

At least 6 outreach and dissemination events as per Table 23a and 24 have been completed

At least 22 other outreaches and dissemination event (as per Table 2.3a and 2.4)

At least 22 other outreaches and dissemination event (as per Table 2.3a and 2.4) have been held

Websites, patent fillings, videos etc. (1)

INNOTARGETS website and other social media online

INNOTARGETS website and other social media is online

Pubblicazioni

Peer reviewed articles (16)

Optimizing phage-based mutant recovery and minimizing heat effect in the construction of transposon libraries in Staphylococcus aureus

Autori: Sally W. Yousief, Nader Abdelmalek, Bianca Paglietti
Pubblicato in: Scientific Reports, Numero 14, 2024, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-024-73731-y

Chromosomal genes modulating fosfomycin susceptibility in uropathogenic <i>Escherichia coli</i> : a genome-wide analysis

Autori: Yibing Ma, Mattia Pirolo, Lily Giarratana, Karen Leth Nielsen, Susanne Häussler, Luca Guardabassi
Pubblicato in: Antimicrobial Agents and Chemotherapy, Numero 69, 2025, ISSN 0066-4804
Editore: American Society for Microbiology
DOI: 10.1128/aac.01417-24

Algebraic differentiation for fast sensitivity analysis of optimal flux modes in metabolic models

Autori: Hester Chapman, Miroslav Kratochvíl, Oliver Ebenhöh, St Elmo Wilken
Pubblicato in: Bioinformatics, Numero 41, 2025, ISSN 1367-4811
Editore: Oxford University Press (OUP)
DOI: 10.1093/bioinformatics/btaf287

The Secondary Resistome of Methicillin-Resistant Staphylococcus aureus to β-Lactam Antibiotics

Autori: Nader Abdelmalek, Sally Waheed Yousief, Martin Saxtorph Bojer, Mosaed Saleh A. Alobaidallah, John Elmerdahl Olsen, Bianca Paglietti
Pubblicato in: Antibiotics, Numero 14, 2025, Pagina/e 112, ISSN 2079-6382
Editore: MDPI AG
DOI: 10.3390/antibiotics14020112

Exploring the susceptome of methicillin-resistant Staphylococcus aureus to oxacillin and cefazolin using integrated transposon-directed insertion site sequencing and proteomics

Autori: Nader Abdelmalek, Sally W. Yousief, Alessandro Tanca, Martin S. Bojer, Mosaed Saleh A. Alobaidallah, John E. Olsen, Bianca Paglietti
Pubblicato in: International Journal of Antimicrobial Agents, Numero 66, 2025, Pagina/e 107652, ISSN 0924-8579
Editore: Elsevier BV
DOI: 10.1016/j.ijantimicag.2025.107652

A Novel Algorithm to Calculate Elementary Modes: Analysis of<i>Campylobacter jejuni</i>Metabolism

Autori: Yanica Said, Dipali Singh, Cristiana Sebu, Mark Poolman
Pubblicato in: Biosystems, 2023, ISSN 1872-8324
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.01.11.521685

Early prediction of potential hepatotoxic metabolites to aid lead selection in drug discovery

Autori: Linda Chiappalupi, Domingo Gargallo-Viola, Antoni Torrens
Pubblicato in: Open Research Europe, Numero 5, 2025, Pagina/e 307, ISSN 2732-5121
Editore: F1000 Research Ltd
DOI: 10.12688/openreseurope.21392.1

Genome-wide identification of tissue-specific fitness genes in murine models of Staphylococcus aureus infection

Autori: Sally W. Yousief, Nader Abdelmalek, Martin S. Bojer, Yibing Ma, Priscila R. Guerra, Sajid Nisar, John E. Olsen, Bianca Paglietti
Pubblicato in: iScience, Numero 29, 2025, Pagina/e 114261, ISSN 2589-0042
Editore: Elsevier BV
DOI: 10.1016/j.isci.2025.114261

Deletion of pcnB affects antibiotic susceptibility in resistant Escherichia coli by reducing copy number of ColE1-family plasmids

Autori: Sandra Marina Wellner, Xiao Fei, Ana Herrero-Fresno, John Elmerdahl Olsen
Pubblicato in: Scientific Reports, Numero 15, 2025, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-025-92308-x

The intrinsic macrolide resistome of <i>Escherichia coli</i>

Autori: Yibing Ma, Mattia Pirolo, Bimal Jana, Viktor Hundtofte Mebus, Luca Guardabassi
Pubblicato in: Antimicrobial Agents and Chemotherapy, Numero 68, 2024, ISSN 0066-4804
Editore: American Society for Microbiology
DOI: 10.1128/aac.00452-24

Screening Actinomycetes extracts for antimicrobial compounds against methicillin-resistant Staphylococcus aureus and helper-compounds against aminoglycoside-resistant E. coli

Autori: Dina Al Nahhas, Sandra Marina Wellner, Margherita Sosio, Sonia I Maffioli, Salvatore Pisanu, Sergio Uzzau, Daniela Pagnozzi, Stefano Donadio, John Elmerdahl Olsen
Pubblicato in: Open Research Europe, Numero 5, 2025, Pagina/e 110, ISSN 2732-5121
Editore: F1000 Research Ltd
DOI: 10.12688/openreseurope.19988.1

Comparative proteomics analysis of MRSA under different experimental conditions

Autori: Dina Al Nahhas, Salvatore Pisanu, Alessandro Tanca, Bianca Paglietti, Antonella Santona, Sergio Uzzau, Daniela Pagnozzi
Pubblicato in: Scientific Reports, Numero 15, 2025, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-025-04224-9

A novel high-throughput screening method for identifying compounds that inhibit plasmid conjugation

Autori: Jennifer Moussa, Domingo Gargallo-Viola, Line Elnif Thomsen
Pubblicato in: MethodsX, Numero 12, 2025, Pagina/e 102740, ISSN 2215-0161
Editore: Elsevier BV
DOI: 10.1016/j.mex.2024.102740

Genome-wide identification of fitness-genes in aminoglycoside-resistant Escherichia coli during antibiotic stress

Autori: Sandra Marina Wellner, Mosaed Saleh A. Alobaidallah, Xiao Fei, Ana Herrero-Fresno, John Elmerdahl Olsen
Pubblicato in: Scientific Reports, Numero 14, 2024, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-024-54169-8

Macrolide Resistance and In Vitro Potentiation by Peptidomimetics in Porcine Clinical Escherichia coli

Autori: Yibing Ma, Mattia Pirolo https://orcid.org/0000-0002-9814-1500 Prabha Subramani, Ronette Gehring, Peter Damborg https://orcid.org/0000-0001-9932-5996 Henrik Franzyk https://orcid.org/0000-0002-2822-1927 Luca Guardabassi https://orcid.org/0000-0002-2389-5084
Pubblicato in: mSphere, Numero vol 7 number 5, 2023, ISSN 2379-5042
Editore: American Society for Microbiology
DOI: 10.1128/msphere.00402-22

Genome-wide Identification of conditionally essential genes supporting <i>Streptococcus suis</i> growth in serum and cerebrospinal fluid

Autori: Maria Juanpere-Borras, Tiantong Zhao, Jos Boekhorst, Blanca Fernandez-Ciruelos, Rajrita Sanyal, Nissa Arifa, Troy Wagenaar, Peter van Baarlen, Jerry M. Wells
Pubblicato in: Virulence, Numero 17, 2025, ISSN 2150-5594
Editore: Landes Bioscience
DOI: 10.1080/21505594.2025.2600145