Actionable eUropean ROadmap for early-life health Risk Assessment of micro- and nanoplastics

Informations projet

AURORA

N° de convention de subvention: 964827

DOI

10.3030/964827

Date de signature de la CE 2 Février 2021

Date de début 1 Avril 2021

Date de fin 30 Septembre 2026

Financé au titre de

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coût total

€ 5 996 315,00

Contribution de l’UE

€ 5 996 315,00

Coordonné par

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (3)

HRMS profiling of placenta or cord blood metabolome

Report describing the results of the HRMS analyses on biological samples from the BISC and Environage cohort.

Cluster brochure

Leaflet describing the cluster activities and participating projects

Protocols of high-throughput analysis of MNPs

A description of the key requirements to scale analytical methods for population screening including: 1) benchmark quantification methods for MNPs using untargeted Pyr-HRMS against traditional targeted approaches ; 2) identification of best practices for standard selection, eliminating background contamination and reagent purity; 3) evaluation of the effect of sample preparation on MNP chemistry.

Demonstrators, pilots, prototypes (1)

Sample pre-processing workflow and standard operating procedures for measuring MNPs in complex human sample matrices

A report describing workflows and SOPs using the optimized methods – describing the effects of sample treatments on 1) formation of secondary NPs and 2) effects of these treatments on NP, which may react differently than the larger MNPs.

Websites, patent fillings, videos etc. (1)

Database of spectroscopic and morphological fingerprints of aged MNPs

Database on the chemical and morphological changes occurring during NP formation, as well as on the surface of the parent plastic. This will provide a key deliverable supporting MNP risk assessment through developing a database of signatures for in-depth characterization of MNPs.

Publications

Other (4)

Experimental human placental models for studying uptake, transport and toxicity of micro- and nanoplastics

Auteurs: Hanna M. Dusza a 1, Jeske van Boxel b 1, Majorie B.M. van Duursen b, Markus M. Forsberg c, Juliette Legler a, Kirsi H. Vähäkangas c
Publié dans: Elsevier ScienceDirect, Numéro volume 860, 20 february 2023, 2023, Page(s) 160403
Éditeur: Elsevier, Science direct

Progress Towards an Accurate Detection, Characterization, and Exposure Assessment of Micro and Nanoplastics to Support Risk Assessments for Early Life Health Within the AURORA Project

Auteurs: Mandemaker, Laurens D. B.; Dusza, Hanna; Meirer, Florian; van Boxel, Jesker; van Duursen, Majorie; Forsberg, Markus; Legler, Juliette; Vähäkangas, Kirsi; Zimmermann, Lisa
Publié dans: online: https://zenodo.org/records/7968133 - online brochure/poster, Numéro May 25, 2023 - v1, 2023
Éditeur: zenodo.org & AURORA/CUSP
DOI: 10.5281/zenodo.7968132

Spectro‐Microscopic Techniques for Studying Nanoplastics in the Environment and in Organisms

Auteurs: Laurens D. B. Mandemaker; Florian Meirer
Publié dans: Angewandte Chemie - International Edition, Numéro October 24, 2022, 2022
Éditeur: Wiley-Blackwell
DOI: 10.1002/anie.202210494

CUSP Brochure

Auteurs: CUSP
Publié dans: ZENODO, Numéro January 12, 2022, 2022
Éditeur: CUSP: www.cusp-research.eu
DOI: 10.5281/zenodo.5837595

Conference proceedings (1)

Sample Pre-processing Protocols for the (Spectro-)Microscopic Analysis of Micro- & Nanoplastics (MNPs) in Maternal and Fetal Tissues

Auteurs: Zoutendijk, Laura M.; Mandemaker, Laurens D. B.; Matla, Zenzi; Zimmermann, Lisa; van Dalen, Lonneke; Weckhuysen, Bert M.; Meirer, Florian
Publié dans: Numéro 1, 2023
Éditeur: Zenodo
DOI: 10.5281/zenodo.7967295