Actionable eUropean ROadmap for early-life health Risk Assessment of micro- and nanoplastics

Livrables

Sample pre-processing workflow and standard operating procedures for measuring MNPs in complex human sample matrices

A report describing workflows and SOPs using the optimized methods – describing the effects of sample treatments on 1) formation of secondary NPs and 2) effects of these treatments on NP, which may react differently than the larger MNPs.

Database of spectroscopic and morphological fingerprints of aged MNPs

Database on the chemical and morphological changes occurring during NP formation, as well as on the surface of the parent plastic. This will provide a key deliverable supporting MNP risk assessment through developing a database of signatures for in-depth characterization of MNPs.

Cluster brochure

Leaflet describing the cluster activities and participating projects

Protocols of high-throughput analysis of MNPs

A description of the key requirements to scale analytical methods for population screening including: 1) benchmark quantification methods for MNPs using untargeted Pyr-HRMS against traditional targeted approaches ; 2) identification of best practices for standard selection, eliminating background contamination and reagent purity; 3) evaluation of the effect of sample preparation on MNP chemistry.

Publications

Experimental human placental models for studying uptake, transport and toxicity of micro- and nanoplastics

Auteurs: Hanna M. Dusza a 1, Jeske van Boxel b 1, Majorie B.M. van Duursen b, Markus M. Forsberg c, Juliette Legler a, Kirsi H. Vähäkangas c
Publié dans: Elsevier ScienceDirect, Numéro volume 860, 20 february 2023, 2023, Page(s) 160403
Éditeur: Elsevier, Science direct

Progress Towards an Accurate Detection, Characterization, and Exposure Assessment of Micro and Nanoplastics to Support Risk Assessments for Early Life Health Within the AURORA Project

Auteurs: Mandemaker, Laurens D. B.; Dusza, Hanna; Meirer, Florian; van Boxel, Jesker; van Duursen, Majorie; Forsberg, Markus; Legler, Juliette; Vähäkangas, Kirsi; Zimmermann, Lisa
Publié dans: online: https://zenodo.org/records/7968133 - online brochure/poster, Numéro May 25, 2023 - v1, 2023
Éditeur: zenodo.org & AURORA/CUSP
DOI: 10.5281/zenodo.7968132

Spectro‐Microscopic Techniques for Studying Nanoplastics in the Environment and in Organisms

Auteurs: Laurens D. B. Mandemaker; Florian Meirer
Publié dans: Angewandte Chemie - International Edition, Numéro October 24, 2022, 2022
Éditeur: Wiley-Blackwell
DOI: 10.1002/anie.202210494

CUSP Brochure

Auteurs: CUSP
Publié dans: ZENODO, Numéro January 12, 2022, 2022
Éditeur: CUSP: www.cusp-research.eu
DOI: 10.5281/zenodo.5837595

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