Actionable eUropean ROadmap for early-life health Risk Assessment of micro- and nanoplastics

Projektinformationen

AURORA

ID Finanzhilfevereinbarung: 964827

DOI

10.3030/964827

EK-Unterschriftsdatum 2 Februar 2021

Startdatum 1 April 2021

Enddatum 30 September 2026

Finanziert unter

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Gesamtkosten

€ 5 996 315,00

EU-Beitrag

€ 5 996 315,00

Koordiniert durch

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands

CORDIS bietet Links zu öffentlichen Ergebnissen und Veröffentlichungen von HORIZONT-Projekten.

Links zu Ergebnissen und Veröffentlichungen von RP7-Projekten sowie Links zu einigen Typen spezifischer Ergebnisse wie Datensätzen und Software werden dynamisch von OpenAIRE abgerufen.

Leistungen

Documents, reports (3)

HRMS profiling of placenta or cord blood metabolome

Report describing the results of the HRMS analyses on biological samples from the BISC and Environage cohort.

Cluster brochure

Leaflet describing the cluster activities and participating projects

Protocols of high-throughput analysis of MNPs

A description of the key requirements to scale analytical methods for population screening including: 1) benchmark quantification methods for MNPs using untargeted Pyr-HRMS against traditional targeted approaches ; 2) identification of best practices for standard selection, eliminating background contamination and reagent purity; 3) evaluation of the effect of sample preparation on MNP chemistry.

Demonstrators, pilots, prototypes (1)

Sample pre-processing workflow and standard operating procedures for measuring MNPs in complex human sample matrices

A report describing workflows and SOPs using the optimized methods – describing the effects of sample treatments on 1) formation of secondary NPs and 2) effects of these treatments on NP, which may react differently than the larger MNPs.

Websites, patent fillings, videos etc. (1)

Database of spectroscopic and morphological fingerprints of aged MNPs

Database on the chemical and morphological changes occurring during NP formation, as well as on the surface of the parent plastic. This will provide a key deliverable supporting MNP risk assessment through developing a database of signatures for in-depth characterization of MNPs.

Veröffentlichungen

Peer reviewed articles (8)

Functional structure of local connections and differentiation of cerebral cortex areas in the neonate

Autoren: Jesus Pujol, Laura Blanco-Hinojo, Cecilia Persavento, Gerard Martínez-Vilavella, Carles Falcón, Mireia Gascón, Ioar Rivas, Marc Vilanova, Joan Deus, Juan Domingo Gispert, Maria Dolors Gómez-Roig, Elisa Llurba, Payam Dadvand, Jordi Sunyer
Veröffentlicht in: NeuroImage, Ausgabe 298, 2025, Seite(n) 120780, ISSN 1053-8119
Herausgeber: Academic Press
DOI: 10.1016/j.neuroimage.2024.120780

Development of a reliable preprocessing protocol for fluorescent micro- and nanoplastic analysis in human placental tissue

Autoren: Laura M Zoutendijk, Zenzi Matla, Hanna M Dusza, Barbara M Scholz-Böttcher, Bert M Weckhuysen, Laurens D B Mandemaker, Florian Meirer
Veröffentlicht in: Environmental Toxicology and Chemistry, Ausgabe 44, 2025, Seite(n) 2818-2831, ISSN 0730-7268
Herausgeber: Society of Environmental Toxicology and Chemistry
DOI: 10.1093/etojnl/vgaf177

Air pollution and fetal brain morphological development: a prospective cohort study

Autoren: Laura Gómez-Herrera, Yu Zhao, Ioar Rivas, Elisenda Eixarch, Carla Domínguez-Gallardo, Toni Galmes, Marta Muniesa, Maria Julia Zanini, Alan Domínguez, Marta Cirach, Mark Nieuwenhuijsen, Xavier Basagaña, Xavier Querol, Maria Foraster, Mariona Bustamante, Jesus Pujol, Mireia Gascon, Elisa Llurba, María Dolores Gómez-Roig, Payam Dadvand, Jordi Sunyer
Veröffentlicht in: The Lancet Planetary Health, Ausgabe 9, 2025, Seite(n) e480-e490, ISSN 2542-5196
Herausgeber: Elsevier BV
DOI: 10.1016/s2542-5196(25)00093-2

Advancements in Assays for Micro- and Nanoplastic Detection: Paving the Way for Biomonitoring and Exposomics Studies

Autoren: Kuanliang Shao, Runyu Zou, Zhuoyue Zhang, Laurens D.B. Mandemaker, Sarah Timbie, Ronald D. Smith, Amanda M. Durkin, Hanna M. Dusza, Florian Meirer, Bert M. Weckhuysen, Tanya L. Alderete, Roel Vermuelen, Douglas I. Walker
Veröffentlicht in: Annual Review of Pharmacology and Toxicology, Ausgabe 65, 2025, Seite(n) 567-585, ISSN 0362-1642
Herausgeber: Annual Reviews, Inc.
DOI: 10.1146/annurev-pharmtox-030424-112828

Extremely high levels of PBDEs in children’s toys from European markets: causes and implications for the circular economy

Autoren: Chijioke Olisah, Lisa Melymuk, Ondrej Audy, Petr Kukucka, Petra Pribylova, Martin Boudot
Veröffentlicht in: Environmental Sciences Europe, Ausgabe 36, 2024, ISSN 2190-4715
Herausgeber: Springer Science and Business Media LLC
DOI: 10.1186/s12302-024-00999-2

Investigating Exposure and Hazards of Micro- and Nanoplastics During Pregnancy and Early Life (AURORA Project): Protocol for an Interdisciplinary Study

Autoren: Amanda M Durkin, Runyu Zou, Justin M Boucher, Matthew SP Boyles, Jeske van Boxel, Mariona Bustamante, Emily A Christopher, Payam Dadvand, Hanna M Dusza, Majorie van Duursen, Markus M Forsberg, Karen S Galea, Juliette Legler, Laurens DB Mandemaker, Florian Meirer, Jane Muncke, Tim S Nawrot, Petra Přibylová, Anna R Robuck, Nelly D Saenen, Barbara M Scholz-Böttcher, Kuanliang Shao, Martine Vrijhei
Veröffentlicht in: JMIR Research Protocols, Ausgabe 13, 2024, Seite(n) e63176, ISSN 1929-0748
Herausgeber: JMIR Publications Inc.
DOI: 10.2196/63176

Concentrations of per- and polyfluoroalkyl substances (PFAS) in paired tap water and blood samples during pregnancy

Autoren: Dora Cserbik, Maribel Casas, Cintia Flores, Alexandra Paraian, Line Småstuen Haug, Ioar Rivas, Mariona Bustamante, Payam Dadvand, Jordi Sunyer, Martine Vrijheid, Cristina M. Villanueva
Veröffentlicht in: Journal of Exposure Science & Environmental Epidemiology, Ausgabe 34, 2024, Seite(n) 90-96, ISSN 1559-0631
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41370-023-00581-7

Interlaboratory Comparison Reveals State of the Art in Microplastic Detection and Quantification Methods

Autoren: Dmitri Ciornii, Vasile-Dan Hodoroaba, Nizar Benismail, Alina Maltseva, Juan F. Ferrer, Jiamin Wang, Raquel Parra, Ronan Jézéquel, Justine Receveur, Dina Gabriel, Andreas Scheitler, Christa van Oversteeg, Jorg Roosma, Alex van Renesse van Duivenbode, Tim Bulters, Michela Zanella, Alessandro Perini, Federico Benetti, Dora Mehn, Georg Dierkes, Michael Soll, Takahisa Ishimura, Marius Bednarz, Guyu P
Veröffentlicht in: Analytical Chemistry, Ausgabe 97, 2025, Seite(n) 8719-8728, ISSN 0003-2700
Herausgeber: American Chemical Society
DOI: 10.1021/acs.analchem.4c05403

Other (8)

Experimental human placental models for studying uptake, transport and toxicity of micro- and nanoplastics

Autoren: Hanna M. Dusza a 1, Jeske van Boxel b 1, Majorie B.M. van Duursen b, Markus M. Forsberg c, Juliette Legler a, Kirsi H. Vähäkangas c
Veröffentlicht in: Elsevier ScienceDirect, Ausgabe volume 860, 20 february 2023, 2023, Seite(n) 160403
Herausgeber: Elsevier, Science direct

Progress Towards an Accurate Detection, Characterization, and Exposure Assessment of Micro and Nanoplastics to Support Risk Assessments for Early Life Health Within the AURORA Project

Autoren: Mandemaker, Laurens D. B.; Dusza, Hanna; Meirer, Florian; van Boxel, Jesker; van Duursen, Majorie; Forsberg, Markus; Legler, Juliette; Vähäkangas, Kirsi; Zimmermann, Lisa
Veröffentlicht in: online: https://zenodo.org/records/7968133 - online brochure/poster, Ausgabe May 25, 2023 - v1, 2023
Herausgeber: zenodo.org & AURORA/CUSP
DOI: 10.5281/zenodo.7968132

PlasticsFatE Deliverable Report D7.6 Cluster Brochure

Autoren: Tobin, Lesley; Kienzl, Sabine; Mata, Virginia; Vivani, Laura; Muncke, Jane; Boucher, Justin
Veröffentlicht in: PlasticsFatE Deliverable Report D7.6 Cluster Brochure, Ausgabe 6, 2023
Herausgeber: Zenodo
DOI: 10.5281/zenodo.8092258

PlasticsFatE Deliverable Report D7.7 Joint policy briefs 1

Autoren: Foss Hansen, Stephen; Hernandez, Alba
Veröffentlicht in: PlasticsFatE Deliverable Report D7.7 Joint policy briefs 1, Ausgabe 6, 2023
Herausgeber: Zenodo
DOI: 10.5281/zenodo.8092278

Spectro‐Microscopic Techniques for Studying Nanoplastics in the Environment and in Organisms

Autoren: Laurens D. B. Mandemaker; Florian Meirer
Veröffentlicht in: Angewandte Chemie - International Edition, Ausgabe October 24, 2022, 2022
Herausgeber: Wiley-Blackwell
DOI: 10.1002/anie.202210494

PlasticsFatE Deliverable Report D7.5 Cluster web portal and visual identity

Autoren: Tobin, Lesley; Muncke, Jane; Vivani, Laura; Kienzl, Sabine; Mata Marcano, Virginia; Steinbach, Christoph; Roordink, Danielle; Boucher, Justin
Veröffentlicht in: PlasticsFatE Deliverable Report D7.5 Cluster web portal and visual identity, Ausgabe 6, 2023
Herausgeber: Zenodo
DOI: 10.5281/zenodo.8092193

Impacts of micro- and nanoplastics on early-life health

Autoren: Christopher, Emily A.; Christopher-de Vries, Yvette; Devadoss, Anitha; Mandemaker, Laurens D.B.; van Boxel, Jeske; Copsey, Helena M.; Dusza, Hanna M.; Legler, Juliette; Meirer, Florian; Muncke, Jane; Nawrot, Tim S.; Saenen, Nelly D.; Scholz-Böttcher, Barbara M.; Tran, Lang; Weckhuysen, Bert M.; Zou, Runyu; Zimmermann, Lisa; Galea, Karen S.; Vermeulen, Roel; Boyles, Matthew S.P.
Veröffentlicht in: Microplastics and Nanoplastics, Ausgabe 2, 2024
Herausgeber: Springer Open
DOI: 10.1186/s43591-024-00089-3

CUSP Brochure

Autoren: CUSP
Veröffentlicht in: ZENODO, Ausgabe January 12, 2022, 2022
Herausgeber: CUSP: www.cusp-research.eu
DOI: 10.5281/zenodo.5837595

Conference proceedings (1)

Sample Pre-processing Protocols for the (Spectro-)Microscopic Analysis of Micro- & Nanoplastics (MNPs) in Maternal and Fetal Tissues

Autoren: Zoutendijk, Laura M.; Mandemaker, Laurens D. B.; Matla, Zenzi; Zimmermann, Lisa; van Dalen, Lonneke; Weckhuysen, Bert M.; Meirer, Florian
Veröffentlicht in: Ausgabe 1, 2023
Herausgeber: Zenodo
DOI: 10.5281/zenodo.7967295