Actionable eUropean ROadmap for early-life health Risk Assessment of micro- and nanoplastics

Informazioni relative al progetto

AURORA

ID dell’accordo di sovvenzione: 964827

DOI

10.3030/964827

Data della firma CE 2 Febbraio 2021

Data di avvio 1 Aprile 2021

Data di completamento 30 Settembre 2026

Finanziato da

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Costo totale

€ 5 996 315,00

Contributo UE

€ 5 996 315,00

Coordinato da

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (3)

HRMS profiling of placenta or cord blood metabolome

Report describing the results of the HRMS analyses on biological samples from the BISC and Environage cohort.

Cluster brochure

Leaflet describing the cluster activities and participating projects

Protocols of high-throughput analysis of MNPs

A description of the key requirements to scale analytical methods for population screening including: 1) benchmark quantification methods for MNPs using untargeted Pyr-HRMS against traditional targeted approaches ; 2) identification of best practices for standard selection, eliminating background contamination and reagent purity; 3) evaluation of the effect of sample preparation on MNP chemistry.

Demonstrators, pilots, prototypes (1)

Sample pre-processing workflow and standard operating procedures for measuring MNPs in complex human sample matrices

A report describing workflows and SOPs using the optimized methods – describing the effects of sample treatments on 1) formation of secondary NPs and 2) effects of these treatments on NP, which may react differently than the larger MNPs.

Websites, patent fillings, videos etc. (1)

Database of spectroscopic and morphological fingerprints of aged MNPs

Database on the chemical and morphological changes occurring during NP formation, as well as on the surface of the parent plastic. This will provide a key deliverable supporting MNP risk assessment through developing a database of signatures for in-depth characterization of MNPs.

Pubblicazioni

Peer reviewed articles (8)

Functional structure of local connections and differentiation of cerebral cortex areas in the neonate

Autori: Jesus Pujol, Laura Blanco-Hinojo, Cecilia Persavento, Gerard Martínez-Vilavella, Carles Falcón, Mireia Gascón, Ioar Rivas, Marc Vilanova, Joan Deus, Juan Domingo Gispert, Maria Dolors Gómez-Roig, Elisa Llurba, Payam Dadvand, Jordi Sunyer
Pubblicato in: NeuroImage, Numero 298, 2025, Pagina/e 120780, ISSN 1053-8119
Editore: Academic Press
DOI: 10.1016/j.neuroimage.2024.120780

Development of a reliable preprocessing protocol for fluorescent micro- and nanoplastic analysis in human placental tissue

Autori: Laura M Zoutendijk, Zenzi Matla, Hanna M Dusza, Barbara M Scholz-Böttcher, Bert M Weckhuysen, Laurens D B Mandemaker, Florian Meirer
Pubblicato in: Environmental Toxicology and Chemistry, Numero 44, 2025, Pagina/e 2818-2831, ISSN 0730-7268
Editore: Society of Environmental Toxicology and Chemistry
DOI: 10.1093/etojnl/vgaf177

Air pollution and fetal brain morphological development: a prospective cohort study

Autori: Laura Gómez-Herrera, Yu Zhao, Ioar Rivas, Elisenda Eixarch, Carla Domínguez-Gallardo, Toni Galmes, Marta Muniesa, Maria Julia Zanini, Alan Domínguez, Marta Cirach, Mark Nieuwenhuijsen, Xavier Basagaña, Xavier Querol, Maria Foraster, Mariona Bustamante, Jesus Pujol, Mireia Gascon, Elisa Llurba, María Dolores Gómez-Roig, Payam Dadvand, Jordi Sunyer
Pubblicato in: The Lancet Planetary Health, Numero 9, 2025, Pagina/e e480-e490, ISSN 2542-5196
Editore: Elsevier BV
DOI: 10.1016/s2542-5196(25)00093-2

Advancements in Assays for Micro- and Nanoplastic Detection: Paving the Way for Biomonitoring and Exposomics Studies

Autori: Kuanliang Shao, Runyu Zou, Zhuoyue Zhang, Laurens D.B. Mandemaker, Sarah Timbie, Ronald D. Smith, Amanda M. Durkin, Hanna M. Dusza, Florian Meirer, Bert M. Weckhuysen, Tanya L. Alderete, Roel Vermuelen, Douglas I. Walker
Pubblicato in: Annual Review of Pharmacology and Toxicology, Numero 65, 2025, Pagina/e 567-585, ISSN 0362-1642
Editore: Annual Reviews, Inc.
DOI: 10.1146/annurev-pharmtox-030424-112828

Extremely high levels of PBDEs in children’s toys from European markets: causes and implications for the circular economy

Autori: Chijioke Olisah, Lisa Melymuk, Ondrej Audy, Petr Kukucka, Petra Pribylova, Martin Boudot
Pubblicato in: Environmental Sciences Europe, Numero 36, 2024, ISSN 2190-4715
Editore: Springer Science and Business Media LLC
DOI: 10.1186/s12302-024-00999-2

Investigating Exposure and Hazards of Micro- and Nanoplastics During Pregnancy and Early Life (AURORA Project): Protocol for an Interdisciplinary Study

Autori: Amanda M Durkin, Runyu Zou, Justin M Boucher, Matthew SP Boyles, Jeske van Boxel, Mariona Bustamante, Emily A Christopher, Payam Dadvand, Hanna M Dusza, Majorie van Duursen, Markus M Forsberg, Karen S Galea, Juliette Legler, Laurens DB Mandemaker, Florian Meirer, Jane Muncke, Tim S Nawrot, Petra Přibylová, Anna R Robuck, Nelly D Saenen, Barbara M Scholz-Böttcher, Kuanliang Shao, Martine Vrijhei
Pubblicato in: JMIR Research Protocols, Numero 13, 2024, Pagina/e e63176, ISSN 1929-0748
Editore: JMIR Publications Inc.
DOI: 10.2196/63176

Concentrations of per- and polyfluoroalkyl substances (PFAS) in paired tap water and blood samples during pregnancy

Autori: Dora Cserbik, Maribel Casas, Cintia Flores, Alexandra Paraian, Line Småstuen Haug, Ioar Rivas, Mariona Bustamante, Payam Dadvand, Jordi Sunyer, Martine Vrijheid, Cristina M. Villanueva
Pubblicato in: Journal of Exposure Science & Environmental Epidemiology, Numero 34, 2024, Pagina/e 90-96, ISSN 1559-0631
Editore: Nature Publishing Group
DOI: 10.1038/s41370-023-00581-7

Interlaboratory Comparison Reveals State of the Art in Microplastic Detection and Quantification Methods

Autori: Dmitri Ciornii, Vasile-Dan Hodoroaba, Nizar Benismail, Alina Maltseva, Juan F. Ferrer, Jiamin Wang, Raquel Parra, Ronan Jézéquel, Justine Receveur, Dina Gabriel, Andreas Scheitler, Christa van Oversteeg, Jorg Roosma, Alex van Renesse van Duivenbode, Tim Bulters, Michela Zanella, Alessandro Perini, Federico Benetti, Dora Mehn, Georg Dierkes, Michael Soll, Takahisa Ishimura, Marius Bednarz, Guyu P
Pubblicato in: Analytical Chemistry, Numero 97, 2025, Pagina/e 8719-8728, ISSN 0003-2700
Editore: American Chemical Society
DOI: 10.1021/acs.analchem.4c05403

Other (6)

Experimental human placental models for studying uptake, transport and toxicity of micro- and nanoplastics

Autori: Hanna M. Dusza a 1, Jeske van Boxel b 1, Majorie B.M. van Duursen b, Markus M. Forsberg c, Juliette Legler a, Kirsi H. Vähäkangas c
Pubblicato in: Elsevier ScienceDirect, Numero volume 860, 20 february 2023, 2023, Pagina/e 160403
Editore: Elsevier, Science direct

Progress Towards an Accurate Detection, Characterization, and Exposure Assessment of Micro and Nanoplastics to Support Risk Assessments for Early Life Health Within the AURORA Project

Autori: Mandemaker, Laurens D. B.; Dusza, Hanna; Meirer, Florian; van Boxel, Jesker; van Duursen, Majorie; Forsberg, Markus; Legler, Juliette; Vähäkangas, Kirsi; Zimmermann, Lisa
Pubblicato in: online: https://zenodo.org/records/7968133 - online brochure/poster, Numero May 25, 2023 - v1, 2023
Editore: zenodo.org & AURORA/CUSP
DOI: 10.5281/zenodo.7968132

Spectro‐Microscopic Techniques for Studying Nanoplastics in the Environment and in Organisms

Autori: Laurens D. B. Mandemaker; Florian Meirer
Pubblicato in: Angewandte Chemie - International Edition, Numero October 24, 2022, 2022
Editore: Wiley-Blackwell
DOI: 10.1002/anie.202210494

PlasticsFatE Deliverable Report D7.5 Cluster web portal and visual identity

Autori: Tobin, Lesley; Muncke, Jane; Vivani, Laura; Kienzl, Sabine; Mata Marcano, Virginia; Steinbach, Christoph; Roordink, Danielle; Boucher, Justin
Pubblicato in: PlasticsFatE Deliverable Report D7.5 Cluster web portal and visual identity, Numero 6, 2023
Editore: Zenodo
DOI: 10.5281/zenodo.8092193

Impacts of micro- and nanoplastics on early-life health

Autori: Christopher, Emily A.; Christopher-de Vries, Yvette; Devadoss, Anitha; Mandemaker, Laurens D.B.; van Boxel, Jeske; Copsey, Helena M.; Dusza, Hanna M.; Legler, Juliette; Meirer, Florian; Muncke, Jane; Nawrot, Tim S.; Saenen, Nelly D.; Scholz-Böttcher, Barbara M.; Tran, Lang; Weckhuysen, Bert M.; Zou, Runyu; Zimmermann, Lisa; Galea, Karen S.; Vermeulen, Roel; Boyles, Matthew S.P.
Pubblicato in: Microplastics and Nanoplastics, Numero 2, 2024
Editore: Springer Open
DOI: 10.1186/s43591-024-00089-3

CUSP Brochure

Autori: CUSP
Pubblicato in: ZENODO, Numero January 12, 2022, 2022
Editore: CUSP: www.cusp-research.eu
DOI: 10.5281/zenodo.5837595

Conference proceedings (1)

Sample Pre-processing Protocols for the (Spectro-)Microscopic Analysis of Micro- & Nanoplastics (MNPs) in Maternal and Fetal Tissues

Autori: Zoutendijk, Laura M.; Mandemaker, Laurens D. B.; Matla, Zenzi; Zimmermann, Lisa; van Dalen, Lonneke; Weckhuysen, Bert M.; Meirer, Florian
Pubblicato in: Numero 1, 2023
Editore: Zenodo
DOI: 10.5281/zenodo.7967295